F2-isoprostane formation, measurement and interpretation: The role of exercise

Nikolaidis, Michalis G.; Kyparos, Antonios; Vrabas, Ioannis S.

doi:10.1016/j.plipres.2010.10.002

Cited by 96 publications

(85 citation statements)

References 187 publications

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“…An increase of the OS biomarkers followed to aerobic and anaerobic acute physical exercise has been shown in numerous investigations, but also is mentioned that in well-training athletes, this is not always fulfilled [37]. In studies developed, in vivo , it was found that chronic exercise could increase the resistance against OS, providing enhanced protection [38][39][40] for this reasons is mentioned that some athletes do not show changes in its levels of biomarkers of OS, since is associated with an adaptive process [5,40].…”

Section: Discussionmentioning

confidence: 97%

Assessment of oxidative stress biomarkers – neuroprostanes and dihomo-isoprostanes – in the urine of elite triathletes after two weeks of moderate-altitude training

García-Flores

Medina

Cejuela

et al. 2016

Free Radical Research

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Section: Discussionmentioning

confidence: 97%

Assessment of oxidative stress biomarkers – neuroprostanes and dihomo-isoprostanes – in the urine of elite triathletes after two weeks of moderate-altitude training

García-Flores

Medina

Cejuela

et al. 2016

Free Radical Research

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“…Although muscle is often presumed to be the major source of plasma F 2 -isoprostane, blood cells and vascular endothelium are also potential sources. 45 Diet also presumably contributes to oxidative stress; however, the differential effects of polyunsaturated fatty acids on oxidative stress balance are not well understood. More work is needed to assess the role of specific dietary nutrients that could either induce oxidative damage or contribute positively to antioxidant defences.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and fatigue in systemic lupus erythematosus

Segal

Thomas

Zhu

et al. 2012

Lupus

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Objective: The objective of this study is to investigate the relationship of oxidative stress to fatigue in systemic lupus erythematosus (SLE). Methods: Patients with a confirmed diagnosis of SLE by ACR criteria and healthy controls completed validated questionnaires to assess depression and fatigue. Fatigue was measured with the Fatigue Severity Scale (FSS) and the Profile of Fatigue (Prof-F). Visual analogue scales (VAS) were also used to assess fatigue and pain. Depression was measured with the Center for Epidemiologic Studies Depression Scale (CES-D). Plasma F2-isoprostane was measured with gas chromatography/mass spectroscopy to assess oxidative stress. Evaluation included medical record review, physical exam and calculation of body mass index (BMI), disease activity (SLEDAI) and damage (SLICC) in the SLE patients. Results: Seventy-one SLE patients with low disease activity (mean SLEDAI = 1.62 standard error (SE) 0.37, range 0–8) were compared to 51 controls. Fatigue-limiting physical activity (defined as FSS ≥ 4) was present in 56% of patients and 12% of controls. F2-isoprostane was higher in SLE patients with fatigue compared to not-fatigued SLE subjects ( p = .0076) who were otherwise similar in ethnicity, disease activity and cardiovascular risk factors. Plasma F2-isoprostane was strongly correlated with FSS and Profile of Somatic Fatigue (Prof-S) ( p < .0001), VAS fatigue ( p = .005), CES-D ( p = .008) and with BMI ( p = .0001.) In a multivariate model, F2-isoprostane was a significant predictor of FSS after adjustment for age, BMI, pain and depression ( p = .0002). Conclusion: Fatigue in SLE patients with low disease activity is associated with increased F2-isoprostane. F2-isoprostane could provide a useful biomarker to explore mitochondrial function and the regulation of oxidative pathways in patients with SLE in whom fatigue is a debilitating symptom.

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“…In addition, other reviews have been devoted to the analysis of the effects of acute and chronic exercise on the levels of oxidant biomarkers in blood and other tissues (Finaud et al, 2006;Bloomer, 2008;Nikolaidis et al, 2011). Alternatively, the central aim of this review is to address the highly multidisciplinary topics of redox biology as related to exercise using an integrative and comparative approach rather than focusing on blood, skeletal muscle or humans.…”

Section: Introductionmentioning

confidence: 99%

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Nikolaidis

Kyparos

Spanou

et al. 2012

Journal of Experimental Biology

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124

152

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SummaryThe central aim of this review is to address the highly multidisciplinary topic of redox biology as related to exercise using an integrative and comparative approach rather than focusing on blood, skeletal muscle or humans. An attempt is also made to redefine ʻoxidative stressʼ as well as to introduce the term ʻalterations in redox homeostasisʼ to describe changes in redox homeostasis indicating oxidative stress, reductive stress or both. The literature analysis shows that the effects of non-muscledamaging exercise and muscle-damaging exercise on redox homeostasis are completely different. Non-muscle-damaging exercise induces alterations in redox homeostasis that last a few hours post exercise, whereas muscle-damaging exercise causes alterations in redox homeostasis that may persist for and/or appear several days post exercise. Both exhaustive maximal exercise lasting only 30s and isometric exercise lasting 1-3min (the latter activating in addition a small muscle mass) induce systemic oxidative stress. With the necessary modifications, exercise is capable of inducing redox homeostasis alterations in all fluids, cells, tissues and organs studied so far, irrespective of strains and species. More importantly, ʻexercise-induced oxidative stressʼ is not an ʻoddityʼ associated with a particular type of exercise, tissue or species. Rather, oxidative stress constitutes a ubiquitous fundamental biological response to the alteration of redox homeostasis imposed by exercise. The hormesis concept could provide an interpretative framework to reconcile differences that emerge among studies in the field of exercise redox biology. Integrative and comparative approaches can help determine the interactions of key redox responses at multiple levels of biological organization.Key words: antioxidant, biomarker, eccentric, free radical, training. THE JOURNAL OF EXPERIMENTAL BIOLOGY 1616The ʻgoodʼ (antioxidants), the ʻbadʼ (reactive species) and the ʻuglyʼ (oxidative stress) 1 The distinction drawn in the section heading is schematically used to parody the popular manichaeistic view that antioxidants are considered 'useful' entities, reactive species are considered 'harmful' entities and oxidative stress is considered a 'negative' state. Certainly, the reality is much more complicated and antioxidants, reactive species and oxidative stress can serve both useful and detrimental roles, which are dependent on the biological context (within an organism), which in turn are greatly dependent on the environmental context (outside an organism). AntioxidantsAdmittedly, to define the term 'antioxidant' is a difficult task. In this paper, antioxidant is defined as any mechanism, structure and/or substance that delays, prevents or removes oxidative modifications to a target molecule (Halliwell and Gutteridge, 2007;Pamplona and Costantini, 2011). Antioxidants can be complex molecules such as the superoxide dismutases and peroxiredoxins, or simpler ones such as uric acid and glutathione (Gutteridge and Halliwell, 2010). They can be broa...

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F2-isoprostane formation, measurement and interpretation: The role of exercise

Cited by 96 publications

References 187 publications

Assessment of oxidative stress biomarkers – neuroprostanes and dihomo-isoprostanes – in the urine of elite triathletes after two weeks of moderate-altitude training

Assessment of oxidative stress biomarkers – neuroprostanes and dihomo-isoprostanes – in the urine of elite triathletes after two weeks of moderate-altitude training

Oxidative stress and fatigue in systemic lupus erythematosus

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

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