F2-Isoprostanes and the kidney

Salahudeen, A. K.; Reckelhoff, Jane F.; Morrow, Jason D.; Roberts, L. Jackson

doi:10.1358/dnp.1998.11.5.863674

Cited by 8 publications

(3 citation statements)

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“…16,17 Therefore, F 2 -IsoPs are considered not only biomarkers, but also direct mediators of renal injury in vivo. 18,19 We recently evaluated urinary F 2 -IsoPs in cats with CKD across different IRIS stages, with the hypothesis that F 2 -IsoPs would increase with CKD progression. However, we found that while urinary F 2 -IsoPs were increased in stage 1, they decreased significantly to subnormal concentrations with progression through stages 2−4.…”

Section: Introductionmentioning

confidence: 99%

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Plasma and urinary F₂-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Granick

Leuin

Trepanier

2020

Journal of Feline Medicine and Surgery

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Objectives Oxidative stress contributes to chronic kidney disease (CKD) progression in humans and rodent models; F2-isoprostanes (F2-IsoPs) are established biomarkers of oxidative stress. Our primary aim was to evaluate plasma F2-IsoPs in cats with International Renal Interest Society stage 1 and 2 CKD, compared with healthy cats, and to determine whether plasma and urinary F2-IsoPs are equivalent biomarkers. The secondary aim was to assess whether consumption of a renal diet enriched in omega-3 fatty acids led to improvements in plasma and urinary F2-IsoPs. Methods Plasma and urinary F2-IsoPs were measured in 24 cats with stage 1 or 2 CKD, and 12 unaffected controls aged ⩾6 years. Twelve CKD cats were re-evaluated after feeding a commercial renal diet for at least 4 weeks. Results Median plasma F2-IsoPs were significantly higher in stage 1 CKD (96.2 pg/ml), early stage 2 CKD (83.2 pg/ml) and late stage 2 CKD (80.8 pg/ml) compared with healthy cats (22.8 pg/ml; P = 0.03−0.002). Median urinary F2-IsoPs were significantly higher in cats with stage 1 CKD (231.2 pg/mg) compared with healthy cats (152.5 pg/mg) or cats with late stage 2 CKD (124.8 pg/mg; P = 0.01). Plasma F2-IsoPs remained increased, while urinary F2-IsoPs fell with transition from stage 1 to stage 2 CKD. Feeding a commercial renal diet led to significant decreases in plasma F2-IsoPs in the small group of cats with stage 1 CKD (25−75% decrease) compared with cats with stage 2 CKD (20% decrease to 53% increase; P = 0.01). Conclusions and relevance Oxidative stress is prominent in cats with stage 1 CKD. Plasma and urinary F2-IsoPs are not interchangeable biomarkers in cats with stage 2 CKD. Placebo-controlled studies are indicated to evaluate dietary or pharmacologic doses of omega-3 fatty acids on redox stress and progression of renal dysfunction in cats with stage 1 CKD.

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Section: Introductionmentioning

confidence: 99%

“…16,17 Therefore, F 2 -IsoPs are considered not only biomarkers, but also direct mediators of renal injury in vivo. 18,19…”

Section: Introductionmentioning

confidence: 99%

Plasma and urinary F₂-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Granick

Leuin

Trepanier

2020

Journal of Feline Medicine and Surgery

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“…3 In addition, a product of the oxidative stress-mediated peroxidation of arachidonic acid, F 2 -isoprostane, also accounts for enhanced vascular activity through activation of thromboxane receptors. 4,5 It is of great significance to identify the source of oxidative stress in animal models of hypertension. The rodent model of deoxycorticosterone acetate (DOCA)-salt hypertension is a widely used animal model of steroid and salt-sensitive hypertension.…”

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Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice

Zhang

Wang

Tidwell

et al. 2011

Kidney International

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We assessed the relative contribution of the mitochondrial respiratory chain and NADPH (nicotinamide adenine dinucleotide phosphate) oxidase to deoxycorticosterone acetate (DOCA)-salt hypertension in mice. The daily mean arterial pressure was monitored by radiotelemetry in DOCA-salt-treated mice given vehicle or the mitochondrial respiratory chain complex I inhibitor rotenone. This treatment produced remarkable attenuation of DOCA-salt hypertension. Similar results were obtained with other inhibitors of mitochondrial function, including 5-hydroxydecanoate (specific for mitochondrial potassium-ATP channels), benzylguanidine (complexes I and III), and the cell-permeable manganese tetrakis (4-benzoic acid) porphyrin (a mimic of mitochondrial superoxide dismutase). In parallel with the blood pressure-lowering effect of rotenone, the DOCA-salt-induced increases in urinary 8-isoprostane excretion and in reactive oxygen species production of isolated kidney mitochondria were both significantly attenuated. Conversely, the DOCA-salt-induced reduction of urinary nitrate/nitrite excretion was significantly elevated. Following DOCA-salt treatment, mice deficient in NADPH oxidase subunits gp91(phox) or p47(phox) exhibited a partial attenuation of the hypertensive response at early but not later time points. Thus, the mitochondrial respiratory chain is a major source of oxidative stress in DOCA-salt hypertension, whereas NADPH oxidase may have a relatively minor role during the early stage of hypertension.

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Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee

et al. 2010

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F2-Isoprostanes and the kidney

Cited by 8 publications

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Plasma and urinary F₂-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Plasma and urinary F₂-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice

Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee

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F2-Isoprostanes and the kidney

Cited by 8 publications

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Plasma and urinary F2-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Plasma and urinary F2-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice

Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee

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Plasma and urinary F₂-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease

Plasma and urinary F₂-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease