F4‐07‐01: Lc and Frontoparietal Network Function in Normal Aging

Mather, Mara; Clewett, David; Kennedy, Briana L.; Nielson, Shawn; Huang, Robert Y. M.; Velasco, Ricardo; Tu, Kristie; jiyoon, Han

doi:10.1016/j.jalz.2018.06.2888

Cited by 2 publications

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“…Furthermore, the results are in line with reviews and empirical studies proposing a preferential role of right-hemispheric fronto-parietal structures for noradrenaline-mediated attentional, and particularly alertness processes in aging 14,17,18 . Robertson 14 summarized evidence suggesting that the integrity and functional connectivity in this network may facilitate attentional functions, and particularly alertness, in old age.…”

Section: Discussionsupporting

confidence: 88%

“…He summarized evidence for a close, bidirectional relationship of the availability of noradrenaline provided by the locus coeruleus, which is decisive for the ability to increase arousal 15,16 , and the integrity of the right fronto-parietal network in aging individuals. The model is supported by a more recent demonstration that higher activity of the noradrenergic system (induced by a handgrip task) increased functional connectivity between the locus coeruleus and the fronto-parietal network to a bigger extent for older compared to younger women 17,18 . Taken together, previous evidence and relevant cognitive reserve models suggest that connectivity in the right fronto-parietal network could be essential for preserved alertness functions in healthy older participants.The present study, therefore, sought out to investigate whether the individual degree of phasic alerting effects is linked to the individual iFC in the cingulo-opercular network and/or right fronto-parietal network in healthy aging.…”

mentioning

confidence: 61%

“…We wanted to investigate whether the same or distinct functional connectivity patterns do underlie preserved phasic alerting effects in healthy older participants. Previous studies suggested that connectivity in the right fronto-parietal network could be essential for preserved alertness functions in healthy older participants 14,17,18 .…”

Section: Discussionmentioning

confidence: 99%

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Right-lateralized fronto-parietal network and phasic alertness in healthy aging

Haupt

Ruiz‐Rizzo

Sorg

et al. 2019

Preprint

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Phasic alerting cues temporarily increase the brain's arousal state. In younger and older participants, visual processing speed in a whole report task, estimated based on the theory of visual attention (TVA), is increased in cue compared to no-cue conditions. The present study assessed whether older participants' ability to profit from warning cues is related to iFC in the cingulo-opercular and/or right fronto-parietal network. We obtained resting-state functional magnetic resonance imaging (rs-fMRI) data from 31 older participants. By combining an independent component analysis and dual regression, we investigated iFC in both networks. A voxel-wise multiple regression in older participants revealed that higher phasic alerting effects on visual processing speed were significantly associated with lower right fronto-parietal network iFC. We then compared healthy older participants to a previously reported sample of healthy younger participants to assess whether behaviour-iFC relationships are age group specific. The comparison revealed that the association between phasic alerting and cingulo-opercular network iFC is significantly lower in older than in younger adults. Additionally, it yielded a stronger association between phasic alerting and right fronto-parietal network iFC in older versus younger participants. The results support a particular role of the right fronto-parietal network in maintaining phasic alerting capabilities in aging.3 IntroductionWarning cues induce short-lived changes in the brain's "state of readiness" defined as phasic alertness 1 . In verbal whole report paradigms of briefly presented letter arrays combined with modelling based on the computational Theory of Visual Attention (TVA), previous studies demonstrated that visual 2 and auditory warning cues 3 increase visual processing speed. Furthermore, we demonstrated that auditory alerting was effective in both healthy younger and older participants 4 .Concerning neural correlates, in younger adults, we found that the individual phasic alerting effect on visual processing speed was related to intrinsic functional connectivity (iFC) in the cingulo-opercular network 5 . IFC was measured in a separate resting-state fMRI session, which allowed to measure ongoing fluctuations of the blood oxygen level dependent (BOLD) signal with a frequency around 0.01-0.1Hz 6 . Spatial patterns of coherent, i.e. correlated, BOLD fluctuations over time (iFC) constitute intrinsic brain networks which are stable on an intra-7 and inter-subject 8,9 level. The cingulo-opercular network (CON) is also referred to as "salience network" 10 or "ventral attention network" 11 . It comprises the anterior prefrontal cortex, anterior insula, frontal operculum, dorsal anterior cingulate cortex, medial superior frontal cortex, and thalamus 12 .With respect to older adults, it is unclear whether their preserved enhancement of visual processing speed following alertness cues relies on the same or a different intrinsic brain network. In a comprehensive review on the role of the...

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 61%

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Right-lateralized fronto-parietal network and phasic alertness in healthy aging

Haupt

Ruiz‐Rizzo

Sorg

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…The present study investigated whether the same or distinct functional connectivity patterns do underlie preserved phasic alerting effects in healthy older participants. Previous studies suggested that the rFPN could be essential for preserved alertness functions in healthy older participants 10,13,15 .…”

Section: Discussionmentioning

confidence: 99%

“…The results are presented on a standard anatomical MNI152 template using MRIcroGL (https://www.mccauslandcenter.sc.edu/mricrogl/source); slice numbers in transverse plane are indicated. in aging 10,13,14 . Robertson 10 summarized evidence suggesting that the integrity and functional connectivity in this network may facilitate attentional functions in old age.…”

Section: Discussionmentioning

confidence: 99%

Right-lateralized fronto-parietal network and phasic alertness in healthy aging

Haupt

Ruiz‐Rizzo

Sorg

et al. 2020

Sci Rep

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Phasic alerting cues temporarily increase the brain's arousal state. In younger and older participants, visual processing speed in a whole report task, estimated based on the theory of visual attention, is higher in cue than no-cue conditions. The present study assessed whether older participants' ability to profit from warning cues is related to intrinsic functional connectivity (iFC) in the cingulo-opercular and/ or right fronto-parietal network. We acquired resting-state functional magnetic resonance imaging data from 31 older participants. By combining an independent component analysis and dual regression, we investigated iFC in both networks. A voxel-wise multiple regression in older participants yielded that higher phasic alerting effects on visual processing speed were significantly related to lower right fronto-parietal network iFC. This result supports a particular role of the right fronto-parietal network in maintaining phasic alerting capabilities in aging. We then compared healthy older participants to a previously reported sample of healthy younger participants to assess whether behaviour-ifc relationships are age group specific. The comparison revealed that the association between phasic alerting and cingulo-opercular network iFC is significantly lower in older than in younger adults.Phasic alertness refers to momentary enhancements of the brain's "state of readiness" due to warning cues 1 . Previous studies, using a whole report task with briefly presented letter arrays and parametric modelling of report performance based on the theory of visual attention (TVA) 2 , demonstrated that perceptual speed of visual processing is enhanced by visual 3 and auditory warning cues 4 . Furthermore, auditory alerting was shown to be effective in both healthy younger and older participants 5 . Concerning neural correlates underlying phasic alerting effects in younger adults, we found that the individual cueing benefits were significantly related to intrinsic functional connectivity (iFC) in the cingulo-opercular network (CON) 6 . IFC refers to spatial patterns of correlated blood oxygen level dependent (BOLD) signal with a frequency of 0.01-0.1 Hz over time 7 . These BOLD fluctuations can be measured using resting-state functional magnetic resonance imaging (rs-fMRI).With respect to older adults, it is unclear whether their preserved phasic alertness response relies on the same intrinsic brain network as in younger adults or a different one. Reviewing the importance of right-hemispheric structures for cognitive reserve 8 , Robertson suggested that the integrity and functional connectivity of the right fronto-parietal network (rFPN) is decisive for the late-life maintenance of attentional abilities and, especially, alertness functions 9,10 . He summarized evidence for a close, bidirectional relationship of the availability of noradrenaline provided by the locus coeruleus, which is decisive for the ability to increase arousal 11,12 , and the integrity of the right fronto-parietal network in aging individuals. The m...

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F4‐07‐01: Lc and Frontoparietal Network Function in Normal Aging

Cited by 2 publications

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Right-lateralized fronto-parietal network and phasic alertness in healthy aging

Right-lateralized fronto-parietal network and phasic alertness in healthy aging

Right-lateralized fronto-parietal network and phasic alertness in healthy aging

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