FABP4 in macrophages facilitates obesity-associated pancreatic cancer progression via the NLRP3/IL-1β axis

Yang, Jian; Liu, Shujie; Li, Yongzheng; Fan, Zhiyao; Meng, Yufan; Zhou, Bin; Zhang, Guangyong; Zhan, Hanxiang

doi:10.1016/j.canlet.2023.216403

Cited by 16 publications

(7 citation statements)

References 67 publications

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“…38 FABP4 is involved in inducing macrophage pyroptosis via NLRP3/IL-1β axis, thereby promoting the migration, invasion, and metastasis in pancreatic cancer cells. 39 Hydrogen inhibits endometrial cancer progression, which is linked to pyroptotic pathway via ROS/ NLRP3/caspase-1/GSDMD. 40 TRIM24 may be participated in the development of endometriosis through the NLRP3/caspase-1/IL-1β pathway.…”

Section: Discussionmentioning

confidence: 99%

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

Liu,

Xie,

et al. 2024

The FASEB Journal

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BackgroundCervical cancer (CC), closely linked to persistent human papillomavirus infection, represents a major health problem for women worldwide. The objective of this study is to elucidate KIF23's role in the development of CC and its regulatory mechanism.MethodsThe bioinformatics methods were utilized to extract pyroptosis‐associated differentially expressed genes (DEGs) and pivot genes from the GSE9750 and GSE63678 datasets, followed by immune infiltration analysis and quantification of these genes' expression. The effects of kinesin family member 23 (KIF23) were verified through functional experiments in vitro and a mouse xenograft model. The NLPR3 activator, nigericin, was applied for further analyzing the potential regulatory mechanism of KIF23 in CC.ResultsA total of 8 pyroptosis‐related DEGs were screened out, among which 4 candidate core genes were identified as candidate hub genes and confirmed upregulation in CC tissues and cells. These genes respectively showed a positive correlation with the infiltration of distinct immune cells or tumor purity. Downregulation of KIF23 could suppress the proliferation, migration, and invasion abilities in CC cells and tumorigenesis through enhancing pyroptosis. Conversely, KIF23 overexpression accelerated the malignant phenotypes of CC cells and inhibited pyroptosis activation, which was blocked by nigericin treatment.ConclusionsKIF23 may play an oncogenic role in CC progression via inhibition of the NLRP3‐mediated pyroptosis pathway.

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Section: Discussionmentioning

confidence: 99%

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

Liu,

Xie,

et al. 2024

The FASEB Journal

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“…It is known that obesity favors the release of pro-inflammatory cytokines such as tumor necrosis factor α and Interleukin-6, which are linked to the development of inflammation, and the onset of cancer [31]. Also, one study found that fatty acid-binding protein 4 (that induces inflammation to promote cancer cell migration, invasion, and metastasis under obese conditions) was overexpressed in the serum of patients with obesity and was associated with poor overall survival in pancreatic cancer [32].…”

Section: Discussionmentioning

confidence: 99%

Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019

Ilic,

Ilic

2024

Cancers

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(1) Background: This study aimed to assess the global burden of pancreatic cancer attributable to a high BMI in 1990–2019. (2) Methods: An ecological study was carried out. Data about deaths and Disability-Adjusted Life Years (DALYs) for pancreatic cancer were extracted from the Global Burden of Disease (GBD) study. The age-standardized rates (ASRs, per 100,000) were presented. In order to determine trends of pancreatic cancer burden, joinpoint regression analysis was used to calculate the average annual percent change (AAPC). (3) Results: The highest ASRs of DALYs of pancreatic cancer were found in the United Arab Emirates (47.5 per 100.000), followed by countries with about 25.0 per 100,000 (such as Hungary, Czechia, and Montenegro). From 1990 to 2019, the ASRs of deaths and DALYs of pancreatic cancer attributable to a high BMI significantly increased (p < 0.001) for both sexes in all ages, and across all SDI quintiles and all GBD regions. The highest fraction of DALYs attributable to a high BMI was found in the United States of America and China (equally about 15.0%), followed by the Russian Federation, India, Germany, and Brazil (about 5.0%, equally). (4) Conclusions: Further analytical epidemiological studies are necessary to elucidate the relationship between pancreatic cancer and a high BMI.

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“…Inflammasome proteins, including NLRP3 and AIM2, contribute to tumorigenesis by modulating immunity and cross-talk between the microenvironment and lung epithelial cells [ 35 ]. Additionally, some pyroptosis can occur in the tumor immune microenvironment through the caspase-1/GSDMD pathway, which will promote numerous malignant phenotypes in tumors including migration, invasion, and metastasis [ 36 ]. On the other hand, activated NLRP3 inflammasome aggregation of Ca 2+ and the generation of reactive oxygen species (ROS) can promote pyroptosis and inhibit the proliferation of non-small cell lung cancer (NSCLC) [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

Liang,

Qin,

et al. 2024

Cell Commun Signal

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Pyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59. Emerging evidences have shown that pyroptosis contributes to many pulmonary diseases, especially lung cancer, and pneumonia. The exact roles of pyroptosis and gasdermin family proteins are tremendously intricate. Besides, there are evidences that pyroptosis contributes to these respiratory diseases. However, it often plays a dual role in these diseases which is a cause for concern and makes it difficult for clinical translation. This review will focus on the multifaceted roles of pyroptosis in respiratory diseases.

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FABP4 in macrophages facilitates obesity-associated pancreatic cancer progression via the NLRP3/IL-1β axis

Cited by 16 publications

References 67 publications

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

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