Fabricated approach for an effective wound dressing material based on a natural gum impregnated with Acalypha indica extract

Abstract

Although acute wounds are common, treatment for a scarless condition remains limited and ineffective as medicated dressings act only as an epidermal coverage and no interdermal interactions happen. This study examined the benefit of Acalypha indica, a traditionally acclaimed plant for wound healing, as a three-dimensional nanofibrous dressing. guar gum, a natural polysaccharide, was chosen as the raw material, in combination with a synthetic copolymer polyvinyl alcohol. A series of polymer blend nanofibers made of 3:7 of 1% wt guar and 10% wt polyvinyl alcohol along with varied ratios of A. indica were prepared using electrospinning. The effect of cross-linking by citric acid on the nanofibers was studied using Fourier transform infrared. A 5% wt A. indica content was optimized in the electrospun solution to get nanosized morphology, roughness, water absorbing capacity, thermal stability, and tensile strength. The composite material was found inhibitory to both Gram-positive and Gram-negative strains as measured by zone of inhibition. The ability of the dressing to support and proliferate human dermal fibroblasts was evaluated by cell proliferation assay and Calcein acetomethyl (AM) staining assay. The results confirmed that the composite dressing could support long-term cell growth in the 9-day cell culture study. The incorporation

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

“…Specifically, a PVA-based device enclosing nanocellulose from pineapple was loaded with Stryphodedron barbatimao extract (water-alcohol solution 96:4 v/v ) [ 115 ], a well-known mixture employed in medicine as an antiseptic, anti-inflammatory, and anti-bacterial remedy [ 158 ]. More recently, PVA/guar gum composite nanofibers were proposed as a carrier of alcoholic extract of Acalypha indica , a traditionally acclaimed plant for wound healing [ 116 ]. The release profiles displayed a constant and slow delivery throughout the experimental time, while a complete release was observed after 38 h. The antimicrobial experiments against E. coli, B. subtilis, S. aureus, P. fluorescens highlighted bacteriostatic action against all microbial strains.…”

Fabrication and Characterization of Chitin Hydrogel Nano Silver Fused Scaffold for Wound Dressing Applications

“…It was then removed off from the medium and the wet weight (W f ) was noted. 12 The ratio of the swelling was calculated using the below equation:…”

“…After slight parching over the shallow area, W w was recorded. 12 The porosity of the scaffold was calculated using the following equation: The FT-IR examination helps to determine functional groups besides to know the compatibility between chitin and other excipients. 13 The spectra of the chitin and chitin hydrogel nanosilver fused scaffold (S5) were recorded sing potassium bromide pellet method in an FT-IR spectrophotometer (JASCO 4100 type A) in the range of 4000 cm -1 to 400 cm -1 .…”

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

“…Despite the efficient incorporation of a wide range of bioactive and therapeutic agents into electrospun nanofibers, the interest for natural compounds remains high [ 4 , 9 , 21 ]. Recent studies report the development of electrospun nanofibrous membranes containing medicinal plant extracts, and their constituents, such as essential oils for wound dressing applications due to their therapeutic properties, cost-effectiveness, and few adverse effects [ 4 , 9 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Plant-derived medicines have a long history of use in traditional medicine, namely in the treatment of different kinds of wounds [ 22 , 27 , 28 ].…”

“…Plant-derived medicines have a long history of use in traditional medicine, namely in the treatment of different kinds of wounds [ 22 , 27 , 28 ]. Hence, the electrospun nanofibrous meshes containing plant extracts are a promising therapeutic option, and some practical examples were already successfully applied as an advantageous approach to prevent wound bacterial colonization and infection, while provide an appropriate environment for healing [ 4 , 6 , 9 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”