Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer

Aptamer modified Zr-based porphyrinic nanoscale metal–organic frameworks for active-targeted chemo-photodynamic therapy of tumors

“…The cells were harvested and incubated with Apt-MF or Apt-CF for 2 hours respectively. 58 The fluorescence intensity of the cells was determined by flow cytometry after five washes with PBS.…”

“…To assess the hemolysis rate of PCN-224 and DOX@PCN@Apt-M, different concentrations of the material were incubated with blood cells (obtained from BALB/c mice) at 37 °C. 58 After 30 minutes, the supernatant was collected by centrifugation and the hemolysis rate was calculated by measuring the absorption peak at 540 nm using UV-Vis absorption spectroscopy according to the following formula: where A 0 and A 1 are the absorbance of the supernatant when incubation with H 2 O and other solutions, respectively.…”

Aptamer-Functionalized Nanoscale Metal–Organic Frameworks for Targeted Photothermal-Chemo Combined Tumor Therapy

“…Recently, significant advancements have been made in the field of nanotechnology, leading to the emergence of multimodal combinatorial therapy as an attractive choice. − Nanoscale metal–organic frameworks (MOFs) have attracted much attention in tumor therapy with large surface area, high porosity, and good biodegradability. − For example, MOF-199 could be utilized to design tumor PTT therapeutic platforms based on the local surface plasmon resonance (LSPR) effect in the NIR. ,− However, the efficiency of LSPR was limited, resulting in a poor curative effect of MOF-199. Moreover, as a type of semiconductor photosensitizer, CuS nanoparticles (NPs) could generate heat via the d–d* transition and plasmon resonance while absorbing light, thereby exhibiting considerable promise as antitumor agents. − The Wu group synthesized MOF-199, which was used for in situ sulfation of CuS NPs to enhance antibacterial activity.…”

DFT study of Ti3C2 MXene nanosheets as a drug delivery system for 5-fluorouracil

“…28 In 2023, Z. Bai et al showed that under the irradiation of a NIR-I laser, the Ti 3 C 2 core in the DOX/Ti 3 C 2 /Apt-M therapeutic platform enhanced the effect of PTT and promoted the release of the DOX to enhance the chemotherapy effect. 29 To the best of our knowledge, theoretical calculations have not been reported so far on using Ti 3 C 2 as a drug delivery system for uorouracil. Fluorouracil (abbreviated: 5-FU or FU) is one of the common cancer treatment drugs for some cancers, such as breast, stomach and colon.…”

“… 28 In 2023, Z. Bai et al showed that under the irradiation of a NIR-I laser, the Ti 3 C 2 core in the DOX/Ti 3 C 2 /Apt-M therapeutic platform enhanced the effect of PTT and promoted the release of the DOX to enhance the chemotherapy effect. 29 …”