Fabricating Hydroxyapatite–Silk Fibroin Nanocomposite by Bone Bionics

Cui, Biao; Liang, Lie Feng; Xiao, Lu; Weng, Jie

doi:10.4028/www.scientific.net/kem.330-332.345

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Another novel nanocomposite containing SF that might be used as tissue engineering scaffold or bone replacement was obtained by Cui et al (2007) [170]. During its synthesis in an aqueous solution containing SF, hydroxyapatite (HA) nanocrystallites nucleated and grew preferentially along the plane (002) of the HA crystal, suggesting that SF might have an essential role in the mineralization of HA nanocrystallites.…”

Section: Sf Used In the Treatment Of The Bonementioning

confidence: 99%

“…During its synthesis in an aqueous solution containing SF, hydroxyapatite (HA) nanocrystallites nucleated and grew preferentially along the plane (002) of the HA crystal, suggesting that SF might have an essential role in the mineralization of HA nanocrystallites. Moreover, the resulting nanocomposite had a compression strength of 97.6 MPa, which is higher than that of woven bone [ 170 ]. This compression strength was much higher than the one found in the case of the SF-chitosan/nano-hydroxyapatite porous scaffolds by Wen et al (2007) [ 171 ].…”

Section: Sf Involved In the Treatment Of The Eye Bone And Skin Regene...mentioning

confidence: 99%

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The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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Silk fibroin (SF) is a natural protein (biopolymer) extracted from the cocoons of Bombyx mori L. (silkworm). It has many properties of interest in the field of biotechnology, the most important being biodegradability, biocompatibility and robust mechanical strength with high tensile strength. SF is usually dissolved in water-based solvents and can be easily reconstructed into a variety of material formats, including films, mats, hydrogels, and sponges, by various fabrication techniques (spin coating, electrospinning, freeze-drying, and physical or chemical crosslinking). Furthermore, SF is a feasible material used in many biomedical applications, including tissue engineering (3D scaffolds, wounds dressing), cancer therapy (mimicking the tumor microenvironment), controlled drug delivery (SF-based complexes), and bone, eye and skin regeneration. In this review, we describe the structure, composition, general properties, and structure–properties relationship of SF. In addition, the main methods used for ecological extraction and processing of SF that make it a green material are discussed. Lastly, technological advances in the use of SF-based materials are addressed, especially in healthcare applications such as tissue engineering and cancer therapeutics.

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Section: Sf Used In the Treatment Of The Bonementioning

confidence: 99%

Section: Sf Involved In the Treatment Of The Eye Bone And Skin Regene...mentioning

confidence: 99%

The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

View full text Add to dashboard Cite

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Silk Fibroin in Tissue Engineering

Kasoju¹,

Bora²

2012

Adv Healthcare Materials

334

238

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Tissue engineering (TE) is a multidisciplinary field that aims at the in vitro engineering of tissues and organs by integrating science and technology of cells, materials and biochemical factors. Mimicking the natural extracellular matrix is one of the critical and challenging technological barriers, for which scaffold engineering has become a prime focus of research within the field of TE. Amongst the variety of materials tested, silk fibroin (SF) is increasingly being recognized as a promising material for scaffold fabrication. Ease of processing, excellent biocompatibility, remarkable mechanical properties and tailorable degradability of SF has been explored for fabrication of various articles such as films, porous matrices, hydrogels, nonwoven mats, etc., and has been investigated for use in various TE applications, including bone, tendon, ligament, cartilage, skin, liver, trachea, nerve, cornea, eardrum, dental, bladder, etc. The current review extensively covers the progress made in the SF‐based in vitro engineering and regeneration of various human tissues and identifies opportunities for further development of this field.

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Fabricating Hydroxyapatite–Silk Fibroin Nanocomposite by Bone Bionics

Cited by 2 publications

References 12 publications

The Contribution of Silk Fibroin in Biomedical Engineering

The Contribution of Silk Fibroin in Biomedical Engineering

Silk Fibroin in Tissue Engineering

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