Fabricating novel thermal crosslinked ultrafine fibers via electrospinning

Dai, Tianhe; Yu, Hao; Zhang, Kai; Zhu, Meifang; Chen, Yanmo; Adler, Hans‐Juergen P.

doi:10.1002/app.26655

Cited by 7 publications

(10 citation statements)

References 33 publications

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“…A number of techniques such as phase separation, self‐assembly, and electrospinning have been developed to fabricate nano fibrous membranes with unique properties 9, 10. Among these methods, electrospinning has been portraying immense attention due to its effortlessness in producing fibers from materials with diverse origin, including polymers with characteristic diameters ranging from several microns down to tens of nanometers 11…”

Section: Introductionmentioning

confidence: 99%

Fibro‐porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing

Namboodiri

Ramesh

2013

J of Applied Polymer Sci

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A fibro‐porous wound dressing with antibacterial activity was fabricated from polycaprolactone (PCL) solution containing crude extract of biophytum sensitivum (BS) a potential antibacterial herbal drug. Scanning electron microscopy revealed the smooth fibrous morphology of the PCL membrane, whereas the drug‐loaded PCL formed fibers with more interconnective junctions with an average fiber diameter between 1 and 3 μm. Physical characterization of the membrane revealed that it has excellent mechanical stability, water vapor transmission rate and that it promotes water uptake. The release characteristics by total immersion method in phosphate buffer and acetate buffer displayed an increase in drug release with time. Finally, the antibacterial activity of the membrane was tested against standard strains of Staphylococcus aureus and Escherichia coli. PCL membranes loaded with the drug extracts were able to inhibit the growth of bacterial strains which indicated that this fibro‐porous membrane could act as a potential wound‐dressing material to treat various wounds. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Section: Introductionmentioning

confidence: 99%

Fibro‐porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing

Namboodiri

Ramesh

2013

J of Applied Polymer Sci

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“…In recent years, electrospinning has been receiving immense attention because of its effortlessness in the fabrication of fibrous materials with characteristic diameters ranging from several microns down to tens of nanometers 1. This technique was demonstrated more than 100 years ago and was first patented in 1934,2 however, it did not obtain much attention till the early 1990s.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization, mechanical properties, and in vitro cytocompatibility evaluation of fibrous polycarbonate urethane membranes for biomedical applications

Arjun

Ramesh

2012

J Biomedical Materials Res

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This paper reports the electrospinning of a series of oxidatively stable polycarbonate urethanes (PCU) [carbothane (ECT), bionate (EBN), and chronoflex (ECF)] using N,N-dimethyl formamide and tetrahydrofuran as the mixed solvent. The nonwoven membranes were characterized for their structure, performance, and compatibility with cells. Scanning electron microscope was utilized to study the structural morphology and fiber diameter. Microcomputed tomography (micro-CT) was used to characterize the 3D architecture, pore size distribution, and percentage porosity. All the membranes displayed a porous architecture with average fiber diameter in the range of 1.5-2 μm. Static mechanical tests on the membranes revealed that the tensile strength was greater than 7 MPa and the dynamic mechanical tests showed that the average storage modulus (E(i) ) is 2 MPa at 37°C. PCU membranes were subjected to accelerated in vitro degradation for 90 days in 20% hydrogen peroxide/0.1M cobalt chloride solution. Mechanical characterization of the membranes postdegradation confirmed a 64% reduction in tensile strength for EBN at the end of 90 days where as ECF and ECT did not show any significant mechanical property deterioration in the oxidative medium. Cytotoxicity of the membranes was evaluated using L929 fibroblast cells and the results indicated that all the PCU membranes were cytocompatible and showed good adherence to L929 cells. Accordingly, these results highlight the potential of these fibrous PCU membranes for biomedical applications but further in vivo correlation studies are required for better understanding of the biodegradation and biological efficacy.

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“…UPM was prepared and reported in prework.,27 chloroform and benzoyl peroxide (BPO) (initiator) were purchased from Sinopharm Chemical Reagent Co. Ltd. All the chemicals above are of analytical grade and used without further purification. Poly(3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHBV) (Mn 460,000, HV content 3%) were kindly supplied by Ningbo TianAn Co as an injection‐molding grade and was purified before being used.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous work, the preparation of a novel unsaturated polyester macromonomer (UPM) was reported 27. UPM could not be electrospun directly as result of its low viscosity, low molecular weight.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of porous electro‐spun UPM fibers via photocrosslinking

Líu¹,

Yu²,

Cheng³

et al. 2009

J of Applied Polymer Sci

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In this study, a new method of preparing porous ultra-fine fibers via photocrosslinking was developed. Ultra-fine unsaturated polyester macromonomor (UPM)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (UPM/ PHBV) blend fibers were electrospun and then the UPM was photocrosslinked by UV irradiation. Different ratios between UPM, PHBV and solvent were tested and the relationship between weight percentage of solutions and diameter of fibers was discussed. Through the test of T g and T m we found that UPM and PHBV were immiscible and the phase separation proceeded during the electrospinning. The photocrosslinking time was controlled strictly and the best reaction time can't exceed more than 10 min. After photocrosslinking of UPM, PHBV was extracted from the blend fibers with chloroform. The morphology of the fiber was observed through SEM and fibers were not collapsed during the extracted processing.

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Fabricating novel thermal crosslinked ultrafine fibers via electrospinning

Cited by 7 publications

References 33 publications

Fibro‐porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing

Fibro‐porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing

Structural characterization, mechanical properties, and in vitro cytocompatibility evaluation of fibrous polycarbonate urethane membranes for biomedical applications

Preparation of porous electro‐spun UPM fibers via photocrosslinking

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