Fabrication and application of cisplatin-loaded mesoporous magnetic nanobiocomposite: a novel approach to smart cervical cancer chemotherapy

Abstract

There are significant challenges in developing drug carriers for therapeutic perspective. We have investigated a novel nanocarrier system, based on combining functionalized magnetic nanocomposite with Metal–Organic Frameworks (MOFs). Magnetic nanoparticles modified using biocompatible copolymers may be suitable for delivering hydrophobic drugs, such as cisplatin. Furthermore, compared to polymeric nanocarriers, nanocomposite constructed from zeolitic imidazolate framework-8 (ZIF-8) have demonstrated better drug loading capacity, as well as excellent pH-triggered drug release. Cisplatin-encapsulated Fe3O4@SiO2-ZIF-8@N-Chit-FA has been evaluated to determine the antitumor effects of free cisplatin enhancement in cervical cancer cells. In order to increase the stability of the proposed nanocarrier in aqueous solutions, in addition to the density of functional groups, a nano-chitosan layer was coated on top of the magnetic nanocomposite. It was then added with cisplatin onto the surface of Fe3O4@SiO2-ZIF-8@N-Chit-FA to deliver anticancer treatment that could be targeted using a magnetic field. A mouse isograft model of TC1 cells was used to evaluate the in vivo tumor growth inhibition. In tumor-bearing mice, Fe3O4@SiO2-ZIF-8@N-Chit-FA-cisplatin was injected intraperitoneally, and the targeted delivery was amplified by an external magnet (10 mm by 10 mm, surface field strength 0.4 T) fixed over the tumor site. Based on in vivo results, cisplatin-Loaded Mesoporous Magnetic Nanobiocomposite inhibited the growth of cervical tumors (P < 0.001) through the induction of tumor necrosis (P < 0.05) when compared to cisplatin alone. With the application of an external magnetic field, the drug was demonstrated to be able to induce its effects on specific target areas. In summary, Fe3O4 @ SiO2-ZIF-8 @ N-Chit-FA nanocomposites have the potential to be implemented in targeted nanomedicine to deliver bio-functional molecules.

Fabrication of magnetic nanocomposite as responsive drug delivery vehicle for cervical cancer therapy

“…Fe 3 O 4 @SiO 2 @nanochi/FA‐ cis group (treated with Fe 3 O 4 @SiO 2 @NChi/FA‐ cis administered the same as group II). Time period and dose selection were selected based on the previous studies 43,44,66 . When the tumor volume reached 70–100 mm 3 , the treatment was started and continued during the study 67 .…”

“…Also, there was a pH‐dependent release of cisplatin in both A549 and MCF‐7 cell lines 42 . Furthermore, our recent studies have shown that magnetic MOF nanobio‐composites 43 and Mxene‐magnetic nanosheets are capable of carrying cisplatin 44 …”

“…A transparent FA-functionalized chitosan solution was obtained by dissolving chitosan in 1% (w/v) acetic acid and diluting it with deionized water to yield a final concentration of 0.1 (w/v) at pH 5. 43 Sodium tripolyphosphate (TPP) solution was prepared in 0.05% (w/v) deionized water. An equal amount of chitosan solution was mixed vigorously with TPP solution (100 ml), and chitosan-TPP nanoparticles were spontaneously formed through the ionic gelation mechanism of TPP for 15 minutes.…”

“…Time period and dose selection were selected based on the previous studies. 43,44,66 When the tumor volume reached 70-100 mm 3 , the treatment was started and continued during the study. 67 A circular magnetic field (10 mm by 10 mm, 0.4 T surface field strength) was applied externally in group III.…”

Two-dimensional-Ti3C2 magnetic nanocomposite for targeted cancer chemotherapy

“…Furthermore, it is possible to limit the toxicity of a drug by selective activation, which would reduce or eliminate any adverse effects and invasiveness ( Nestler and Lüscher, 2019 ). In addition, several nanomaterials have been demonstrated to possess unique therapeutic potential, such as two-dimensional nanomaterials ( Gong et al, 2017b ; 2017a ; Darroudi et al, 2022 ).…”