textiles that are washable with lifetimes similar to conventional textiles. [9][10][11][12][13] Furthermore, our daily life cannot be without water, such as raining, bathing, swimming, and etc. With underwater wearable electronics, underwater activities can be effectively detected or analyzed, for example monitoring electrophysiological signals for athletes when they are training in the rain or water, detecting the moving, migration or feeling of the living creatures underwater. Therefore, to design stretchable conductive fibers capable of working in full water environment is fundamentally essential. Typical methods of developing stretchable conductive fibers include prestraining polymer fibers to induce the attached 1D conductive species (metal nanowires or carbon nanotubes (CNTs)) into wavy structure, [3,14] wrapping conductive species into spiral shape along an elastic polymer fiber, [3,10,[15][16][17][18][19] or using a conductive liquid or gel encapsulated in an elastomer. [20][21][22] However, liquid metal conductors are susceptible to leakage if the fibers are damaged, while hydrogel conductors dry out over time, and both exhibit changes in conductance of the fibers with strain. Carbon-based conductors have low conductivity with increasing length, [7,9,14,17,23,24] while metal composite conductors typically exhibit limited strain tolerance and poor cycle stability. [25,26] Conductive fibers with waterproof [27] or splash-resistance [28] have been studied, but stretchable conductive fibers that are capable of maintaining good conductivity at high strain as well as fully underwater long-time use have not been systematically reported yet.In this work, we presented a core-sheath stretchable conductive fiber (CSCF) which could be safely used in water and other harsh environments (such as sonication) for a long time. The ultrafine CSCF (≈30 µm in diameter) is composed of Lycra (polyurethane, PU) fiber, multiwall carbon nanotubes (MWCNTs), silver nanowires (AgNWs), and styrene-(ethylenebutylene)-styrene (SEBS) sequentially from inside to outside, which is defined as PU@CNTs@AgNWs@SEBS. Spray coating 1D conductive networks onto a prestraining Lycra fiber resulted in a highly stretchable conductive fiber (e.g., ΔR/R 0 ≈ 0.1 at 100% strain, cycled >100 000 times at 50% strain). Surface coating SEBS enabled a significantly reduced leakage both in current (<1 µA at 5 V) and element (Ag), thus safe to human