Fabrication and biological imaging of hydrazine hydrate cross-linked AIE-active fluorescent polymeric nanoparticles

Liu, Yanzhu; Mao, Liucheng; Yang, Saijiao; Huang, Hongye; Wen, Yuanqing; Deng, Fengjie; Li, Yongxiu; Zhang, Xiaoyong; Wei, Yen

doi:10.1016/j.msec.2018.09.035

Cited by 17 publications

(6 citation statements)

References 52 publications

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“…These FPNs can also be produced from a wide range of monomers and impart greater stability compared to those nanoparticles formed from self-assembly, as FPNs prepared via self-assembly are often unstable in physiological solution due to the weak interactions among these amphiphilic fluorescent molecules. Similar studies have also been conducted by the same group and other groups on preparing AIE dyes via RAFT polymerization capable of self-assembly with similar characteristics since 2014 such as AIE crosslinkers, [87][88][89][90][91][92][93][94] AIE pendent groups with non-AIE monomers block copolymers, [95][96][97][98][99][100][101][102][103] AIE end-functionalized block copolymers, [48,49,[104][105][106][107] and AIE-functionalized monomers, [108][109][110][111][112][113][114][115][116][117][118][119] which helped to expand the library of AIE-functionalized polymers.…”

Section: Raft Aie Amphiphilic Block Copolymersmentioning

confidence: 55%

Aggregation-Induced Emission Polymers via Reversible-Deactivation Radical Polymerization

Teo

Fan

Ardana

et al. 2023

Preprint

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Aggregation-Induced Emission (AIE) is a unique phenomenon whereby aggregation of molecules induces fluorescence emission as opposed to the more commonly known Aggregation-Caused Quenching (ACQ). AIE has the potential to be utilized in the large-scale production of AIE-active polymeric materials because of their wide range of practical applications such as stimuli-responsive sensors, biological imaging agents, and drug delivery systems. This is evident from the increasing number of publications over the years since AIE was first discovered. In addition, the ever-growing interest in this field has led many researchers around the world to develop new and creative methods in the design of monomers, initiators and crosslinkers, with the goal of broadening the scope and utility of AIE polymers. One of the most promising approaches to the design and synthesis of AIE polymers is the use of the Reversible-Deactivation Radical Polymerization (RDRP) techniques, which enabled the production of well-controlled AIE materials that are often difficult to achieve by other methods. In this review, a summary of some recent works that utilize RDRP for AIE polymer design and synthesis is presented, including (1) the design of AIE-related monomers, initiators/crosslinkers; the achievements in preparation of AIE polymers using (2) Reversible Addition-Fragmentation Chain Transfer (RAFT) technique; (3) Atom Transfer Radical Polymerization (ATRP) technique; (4) other techniques such as Cu(0)-RDRP technique and Nitroxide-Mediated Polymerization (NMP) technique; (5) the possible applications of these AIE polymers and finally (6) a summary/perspective and the future direction of AIE polymers.

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Section: Raft Aie Amphiphilic Block Copolymersmentioning

confidence: 55%

Aggregation-Induced Emission Polymers via Reversible-Deactivation Radical Polymerization

Teo

Fan

Ardana

et al. 2023

Preprint

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“…AIE fluorophores without polar groups are usually hydrophobic and, therefore, cannot be directly applied in biological systems. [ 30‐33 ] Incorporating AIE fluorophores into amphiphilic molecules to construct water‐soluble aggregates is a feasible way to solve the above problem. [ 34‐40 ] Many fabrication strategies, such as atom transfer radical polymerization (ATRP), reversible addition‐fragmentation chain transfer (RAFT) polymerization, multicomponent reaction (MCR) and surfactant encapsulation, have been developed for the synthesis of water‐soluble AIE fluorescent probes for biomedical applications.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Zhang

et al. 2023

Chin. J. Chem.

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Comprehensive Summary Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an amphiphilic block copolymer (denoted by PTN). The diblock copolymer was synthesized by RAFT polymerization. A polyethylene glycol‐based trithiocarbonate was employed as the macromolecular chain transfer agent, and a near‐infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the monomer. The block copolymers self‐assembled in an aqueous solution to form nanospheres, which showed near‐infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 nm. Furthermore, nanofluorophores have excellent biocompatibility, photostability, and pH‐independent emission‐tunable properties, and were successfully applied to label HeLa cells for fluorescence imaging.

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“…The development of synthetic strategies with high‐yield and green advantages for fabrication of AIE‐active copolymers is an everlasting theme. [ 127–130 ] Using novel strategies to prepare polymer nanoparticles with unique structures and desirable properties has potential theory significance and industrial application. [ 131,132 ] To our knowledge, different covalent methods such as Schiff base reaction, [ 133 ] emulsion polymerization, [ 32 ] ring‐opening reaction, [ 129 ] and free radical polymerization [ 134 ] have been widely studied to produce desirable AIE polymers with different functional groups in the last few years.…”

Section: Fabrication Of Fluorescent Copolymers With Aie Feature Throumentioning

confidence: 99%

Recent Advances on Fabrication of Polymeric Composites Based on Multicomponent Reactions for Bioimaging and Environmental Pollutant Removal

Yang

Liang

et al. 2021

Macromol. Rapid Commun.

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As the core of polymer chemistry, manufacture of functional polymers is one of research hotspots over the past several decades. Various polymers are developed for diverse applications due to their tunable structures and unique properties. However, traditional step‐by‐step preparation strategies inevitably involve some problems, such as separation, purification, and time‐consuming. The multicomponent reactions (MCRs) are emerging as environmentally benign synthetic strategies to construct multifunctional polymers or composites with pendant groups and designed structures because of their features, such as efficient, fast, green, and atom economy. This mini review summarizes the latest advances about fabrication of multifunctional fluorescent polymers or adsorptive polymeric composites through different MCRs, including Kabachnik–Fields reaction, Biginelli reaction, mercaptoacetic acid locking imine reaction, Debus–Radziszewski reaction, and Mannich reaction. The potential applications of these polymeric composites in biomedical and environmental remediation are also highlighted. It is expected that this mini‐review will promote the development preparation and applications of functional polymers through MCRs.

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Fabrication and biological imaging of hydrazine hydrate cross-linked AIE-active fluorescent polymeric nanoparticles

Cited by 17 publications

References 52 publications

Aggregation-Induced Emission Polymers via Reversible-Deactivation Radical Polymerization

Aggregation-Induced Emission Polymers via Reversible-Deactivation Radical Polymerization

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Recent Advances on Fabrication of Polymeric Composites Based on Multicomponent Reactions for Bioimaging and Environmental Pollutant Removal

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