Fabrication and characterisation of electrospun Polycaprolactone/Polysuccinimide composite meshes

Voniatis, Constantinos; Barczikai, Dóra; Gyulai, Gergö; Jedlovszky-Hajdú, Angéla

doi:10.1016/j.molliq.2020.115094

Cited by 14 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to having the highest vapor pressure examining the viscosity and conductivity study results DMF based solutions had the lowest viscosity and highest conductivity (Table 5) indicating that these parameters are needed to produced quality PSI fibers. While DMSO and DMAc did not produce fibers of equal quality to DMF, these solvents could be potentially beneficial in formulation of binary solutions for electrospinning or blend electrospinning of two polymers 36 . This is further suggested by the chemical analysis, as prominent peaks found in the solvents cannot be found in the corresponding meshes therefore we can conclude that the solvents have indeed evaporated during the electrospinning process and can be utilized without any potential side effects caused by the solvents.…”

Section: Resultsmentioning

confidence: 77%

Enhancing critical features of poly(amino acid) based meshes

Voniatis

Gottscháll

Barczikai

et al. 2021

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

The following manuscript presents a comprehensive investigation regarding the influence of electrospinning parameters on fiber quality and mechanical properties of nanofibrous poly(amino acid) meshes. At first, we examine parameters including: solvent options, polymer concentrations, collector speed and distance, voltage, needle sizes and flow rates to prepare fibrous scaffolds based on polysuccinimide. The main objective was to attempt and decrease the fiber diameter as much as possible while not reducing the fiber quality. After that mechanical properties of the meshes were investigated, we demonstrate two possible methods to reinforce them: mechanically induced alignment of the fibers and multilayer compression. Characterization methods include a solubility study, viscosity and conductivity measurements, ATR‐FTIR spectroscopy, scanning electron microscopy, and mechanical uniaxial test. Fiber size was successfully reduced from 615 to 280 nm without any quality aberrations. Mechanical performance not only improved almost three‐fold, but was also enhanced in two directions due to the multilayer composition. With these optimizations, the PSI mesh now possess favorable features for biomedical application according to the relevant literature.

show abstract

Section: Resultsmentioning

confidence: 77%

Enhancing critical features of poly(amino acid) based meshes

Voniatis

Gottscháll

Barczikai

et al. 2021

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…To avoid this methodology problem in our study, the specific load capacity (Equation (1)) was determined instead of the ultimate strain and the initial modulus (Equation (2)) (see Figures S5–S7, Supporting Information) instead of Young's modulus. [ 32 ]…”

Section: Resultsmentioning

confidence: 99%

“…The specific load capacity was calculated as the ratio of the highest load value from the elongation curves (maximal load) and the area density of the samples (Equation (1)). The area density of the samples was calculated [ 32 ] according to Equation (2):

\begin{equation}{\rm{Specific\;load\;capacity}}\left[ {\frac{{{\rm{N}}{{\rm{m}}^2}}}{{\rm{g}}}} \right] = \frac{{{\rm{Maximal\;load\;}}\left[ {\rm{N}} \right]}}{{{\rm{Area\;density\;}}\left[ {\frac{{\rm{g}}}{{{{\rm{m}}^2}}}} \right]}}\end{equation}

\begin{equation}{\rm{Area\;density}}\left[ {\frac{{\rm{g}}}{{{{\rm{m}}^2}}}} \right] = \frac{{{\rm{Mass\;of\;the\;sample\;}}\left[ {\rm{g}} \right]}}{{{\rm{Surface\;of\;the\;sample\;}}\left[ {{{\rm{m}}^2}} \right]}}\end{equation}

…”

Section: Methodsmentioning

confidence: 99%

Characterization of Electrospun Polysuccinimide‐Dopamine Conjugates and Effect on Cell Viability and Uptake

Tóth

Nagy

Güler

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

Biocompatible nanofibrous systems made by electrospinning have been studied widely for pharmaceutical applications since they have a high specific surface and the capability to make the entrapped drug molecule amorphous, which increases bioavailability. By covalently conjugating drugs onto polymers, the degradation of the drug as well as the fast clearance from the circulation can be avoided. Although covalent polymer–drug conjugates have a lot of advantages, there is a lack of research focusing on their nano‐formulation by electrospinning. In this study, polysuccinimide (PSI) based electrospun fibrous meshes conjugated with dopamine (DA) are prepared. Fiber diameter, mechanical properties, dissolution kinetics and membrane permeability are thoroughly investigated, as these are crucial for drug delivery and implantation. Dopamine release kinetics prove the prolonged release that influenced the viability and morphology of periodontal ligament stem cells (PDLSCs) and SH‐SY5Y cells. The presence of dopamine receptors on both cell types is also demonstrated and the uptake of the conjugates is measured. According to flow cytometry analysis, the conjugates are internalized by both cell types, which is influenced by the chemical structure and physical properties. In conclusion, electrospinning of PSI‐DA conjugates alters release kinetics, meanwhile, conjugated dopamine can play a key role in cellular uptake.

show abstract

“…[ 41 ] Besides, the signal at 1541 cm −1 arises from amide II and the band at 1221 cm −1 corresponds to amide III (both ν(C‐N) and δ(N‐H) in urethane groups). [ 42 ] Finally, peaks at 1157 and 1040 cm −1 can be attributed to ν(C‐O‐C) of PCL ester bond (soft segment, SS) [ 43 ] and ν(C–O–C) urethane stretching vibration (hard segment, HS), [ 44 ] respectively. Signals ascribed to GC particles were not detected.…”

Section: Resultsmentioning

confidence: 99%

Additive manufacturing of bioresorbable poly(ester‐urethane)/glass‐ceramic composite scaffolds

et al. 2022

View full text Add to dashboard Cite

The development of three‐dimensionally printed implants for biomaterial‐based tissue engineering applications is currently an active research field. In order to meet the requirements of several applications, new biocompatible and bioresorbable polymer‐based materials are needed to design tailor‐made polymer/composite scaffolds. In the last decade, bioresorbable segmented poly(ester‐urethanes) (SPEU) have been extensively investigated for their applications in tissue engineering and many biomedical devices. In this work, 3D printed poly(ester‐urethane)/bioceramic composite scaffolds were successfully fabricated by fused deposition modeling for the first time. A twin‐screw extruder was used for making the SPEU composite filaments containing 5% and 10% wt/wt of glass‐ceramic particles. Both filaments and scaffolds were physically and chemically studied in terms of morphology, thermal properties, wettability, and mechanical properties. The resulting composite scaffolds could be remarkably interesting for potential applications in soft tissue engineering.

show abstract

Fabrication and characterisation of electrospun Polycaprolactone/Polysuccinimide composite meshes

Cited by 14 publications

References 36 publications

Enhancing critical features of poly(amino acid) based meshes

Enhancing critical features of poly(amino acid) based meshes

Characterization of Electrospun Polysuccinimide‐Dopamine Conjugates and Effect on Cell Viability and Uptake

Additive manufacturing of bioresorbable poly(ester‐urethane)/glass‐ceramic composite scaffolds

Contact Info

Product

Resources

About