Fabrication and Characterization of 3D Nanostructured Polycaprolactone-Gelatin/Nanohydroxyapatite-Nanoclay Scaffolds for Bone Tissue Regeneration

Nazari, S. Adib; Naeimi, Mitra; Rafienia, Mohammad; Monajjemi, Majid

doi:10.1007/s10924-023-02966-z

Cited by 6 publications

(1 citation statement)

References 79 publications

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“…[19] Nanoclays are layered silicates with a diameter of 50-200 nm, enriching with their properties the composites in which they are used. [20] Research proves that small additions of various types of clays have a significant impact on flammability, mechanical properties, gas permeability and biodegradability. [6] They are also used in pharmaceutical preparations as both active ingredients and excipients.…”

Section: Introductionmentioning

confidence: 97%

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO₂, TiO₂, ZnO)

Kowalska,

Skwarek,

Demianenko

et al. 2024

ChemPhysChem

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In order to improve the structural properties of clays and composites of powdered spirulina, clay, nanosilica, hydroxyapatite, TiO2 and ZnO were used as an additive for mechanical processing. As a result, composites with natural nanostructured materials (NNM) are prepared with improved structural properties and bioactivity. The mixtures based on NNM with crystalline kaolinite, clays and admixtures were processed in a knife mill. The materials were characterized using FTIR spectroscopy, nitrogen adsorption and desorption, SEM release of bioactive components (anthocyanin 0,004 ‐ 0,07 mg/g; chlorophyll 20 ‐ 29 mg/g), composite toxicity level (below 25%), particle size measurement and surface charge density, zeta potential. Adsorption enthalpies during the formation of an intermolecular complex during the interactions of an anthocyanin molecule with the appropriate component of the composite were also calculated. There are regularities in the characteristics depending on the type of NNM, particle morphology and textural features of solids. The morphological and structural properties of the components changed slighty in the blends because the processing was conducted under relatively low mechanical stress. The morphological, textural and structural characteristics of the composites as well as the transformation to a nanostructured state, assume great bioactive activity of the composites, interesting for practical applications.

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Section: Introductionmentioning

confidence: 97%

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO₂, TiO₂, ZnO)

Kowalska,

Skwarek,

Demianenko

et al. 2024

ChemPhysChem

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Development of 3D-Printed PCL/ Baghdadite Nanocomposite Scaffolds for Bone Tissue Engineering Applications

Emadi,

Baghani,

Khodaei

et al. 2024

J Polym Environ

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A signi cant obstacle in bone tissue engineering is the creation of biodegradable bone replacements with the requisite mechanical and biological capabilities to treat more severe and intricately shaped injuries.Baghdadite has recently indicated that active biological ions such as silicon (Si 4+ ) and zirconium (Zr 4+ ) have been proven to increase bone growth considerably. In this study, we produced 3D-printed PCL-based scaffolds containing different amounts of Baghdadite using the robocasting solvent technique. Notably, PCL with 40 and 60 wt.% Baghdadite scaffolds (PB40 and PB60) promoted a more biomimetic environment for in vitro bone growth as their proper bioactivity and cell viability results were obtained without the addition of osteoinductive components. The printing process produced 3D scaffolds with a compressive strength of 7.94 MPa and elastic modulus of 29.95 MPa in PB40. According to the analytical prediction models in PB40, the elastic modulus was 24.7 and 26.89 MPa. Also, adding 60 wt.% Baghdadite increased the degradation rate to 5.1% in two months, more than six times that of PCL-based scaffolds. Cell proliferation assay demonstrated that the optical density of MG63 cells after 7 days of culture increased from 1.43 ± 0.03 to 1.82 ± 0.20 in PB40 as compared to pure PCL scaffold. Furthermore, bioactivity evaluation, ion release assessment, and morphological observation results further revealed that incorporating Baghdadite into a 3D-printed PCL-based scaffold could improve bone regeneration.Our ndings demonstrate that the PCL/Baghdadite composite scaffold may be e ciently manufactured using 3D-printing technology and is extremely promising for bone tissue engineering applications.

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Novel electrospun polyvinyl alcohol/chitosan/polycaprolactone-diltiazem hydrochloride nanocomposite membranes for wound dressing applications

Etemadi,

Mehdikhani,

Huri

et al. 2024

emergent mater.

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Fabrication and Characterization of 3D Nanostructured Polycaprolactone-Gelatin/Nanohydroxyapatite-Nanoclay Scaffolds for Bone Tissue Regeneration

Cited by 6 publications

References 79 publications

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO₂, TiO₂, ZnO)

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO₂, TiO₂, ZnO)

Development of 3D-Printed PCL/ Baghdadite Nanocomposite Scaffolds for Bone Tissue Engineering Applications

Novel electrospun polyvinyl alcohol/chitosan/polycaprolactone-diltiazem hydrochloride nanocomposite membranes for wound dressing applications

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Fabrication and Characterization of 3D Nanostructured Polycaprolactone-Gelatin/Nanohydroxyapatite-Nanoclay Scaffolds for Bone Tissue Regeneration

Cited by 6 publications

References 79 publications

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO2, TiO2, ZnO)

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO2, TiO2, ZnO)

Development of 3D-Printed PCL/ Baghdadite Nanocomposite Scaffolds for Bone Tissue Engineering Applications

Novel electrospun polyvinyl alcohol/chitosan/polycaprolactone-diltiazem hydrochloride nanocomposite membranes for wound dressing applications

Contact Info

Product

Resources

About

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO₂, TiO₂, ZnO)

Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO₂, TiO₂, ZnO)