Fabrication and characterization of antimicrobial wound dressing nanofibrous materials by PVA-betel leaf extract

Akram, Washim; Hoque, Mohammad Mohsin Ul; Miah, Md. Sumon; Shahid, Abdus; Hossain, Mustaque; Mahmud, Sayed Hasan

doi:10.1016/j.heliyon.2023.e17961

Cited by 11 publications

(5 citation statements)

References 52 publications

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“…Porosity was measured by estimating weight and calculating volume based on material thickness using eqs 1 and 2. Briefly, at 20 °C, the densities of PVA and C. grandis extract were 1.19 g/cm 3 and 0.57 g/cm 3 , respectively. To begin, a nanofibrous mat measuring 4 cm × 4 cm was taken, and the weight and thickness were carefully measured using digital balances and micrometers, respectively.…”

Section: Electrospinning Solution Preparationmentioning

confidence: 99%

“…The medical industry is shifting toward wound dressings with herbal ingredients rather than metal-based nanoparticles for antifungal and antibacterial benefits. Even today, herbal remedies are still used for basic healthcare, including wound healing and burn injuries, as well as antifungal, antiviral, and antibacterial applications for skin infections. , Wound dressing materials must provide a micromoist environment, protect against bacterial invasion, limit tissue damage, avoid dehydration, and be biocompatible and biodegradable . Natural herbs have medicinal characteristics that can replace metallic particles in present dressing products, making the development of such materials more relevant.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 Wound dressing materials must provide a micromoist environment, protect against bacterial invasion, limit tissue damage, avoid dehydration, and be biocompatible and biodegradable. 3 Natural herbs have medicinal characteristics that can replace metallic particles in present dressing products, making the development of such materials more relevant. Aromatic plants have historically been used in traditional medicine to extend food lifespan because of their ability to inhibit the growth of bacteria, fungi, and yeasts.…”

Section: Introductionmentioning

confidence: 99%

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Developing and Screening of a Bacteria-Fighting and Moisture-Controlling Coccinia grandis and Poly(vinyl alcohol) Electrospun Nanofibrous Mat

Karim,

Islam,

Alam

et al. 2024

ACS Omega

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Nanofibers are extensively employed in the antimicrobial industry owing to their remarkable properties and diverse applications. Managing wounds poses a significant and enduring challenge for healthcare systems globally. This study aims to produce and evaluate electrospun nanofiber mats made from poly(vinyl alcohol) (PVA) and Coccinia grandis (C. grandis) leaf extract, highlighting the medicinal properties of this herbal product for potential biomedical applications (wound dressing). During the evaluations, a 60:40 ratio of PVA to leaf extract was found to be suitable, and the electrospinning process was utilized for production. Scanning electron microscopy was employed for morphological assessment, and an antibacterial assay was conducted against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) to evaluate cell cytotoxicity. Additionally, Fourier-transform infrared spectroscopy (FTIR) and moisture management behavior (moisture management test) analyses were performed on the fabricated electrospun nanofibrous mat. The formation of small beads was confirmed, with the nanofibers having an average diameter of 295.07 ± 0.0032 nm and a porosity of approximately 76%, which is adequate for oxygen circulation and air ventilation, ensuring skin breathability. Gram-positive bacteria (S. aureus) exhibited a zone of inhibition (ZOI) of 14 mm, while Gram-negative bacteria (E. coli) showed a ZOI of 10 mm, attributed to the presence of a thick peptidoglycan cell wall in Gram-positive bacteria with no cell toxicity (100% cell viability). FTIR confirms the formation of weak van der Waals bonds and represents H-bonds between PVA polymer and C. grandis leaf extract. Furthermore, according to the MMT analysis, the electrospun nanofibrous mat demonstrates rapid absorption and slow drying properties. Therefore, the produced electrospun nanofibrous mat could prove beneficial for wound dressing purposes.

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Section: Electrospinning Solution Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Developing and Screening of a Bacteria-Fighting and Moisture-Controlling Coccinia grandis and Poly(vinyl alcohol) Electrospun Nanofibrous Mat

Karim,

Islam,

Alam

et al. 2024

ACS Omega

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“…PCL underwent degradation when exposed to intestinal fluid, resulting in the formation of 6-hydroxylcaproic acid. Subsequently, this acid underwent further decomposition to produce acetyl-CoA, which ultimately underwent complete oxidation to carbon dioxide and water through the citric acid cycle [37]. During this biodegradation process, the drug encapsulated within the polymer was released near the application site [15].…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Implantable Trilayer Microneedle Transdermal Delivery System to Enhance Bioavailability and Brain Delivery of Rivastigmine for Alzheimer Treatment: a Proof-of-concept Study

Aulia,

Putri,

Pratama

et al. 2023

Preprint

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Rivastigmine (RV), an acetylcholinesterase inhibitor, is commonly used to treat Alzheimer's disease (ALZ). Regrettably, RV is available in the capsule form, associated with reduced drug bioavailability, and in patch form, which may cause skin irritation after repeated use. A controlled RV release implantable trilayer dissolving microneedle (TDMN) was developed in this study to address the issue of RV administration. RV encapsulated in slow-biodegrading polycaprolactone (PCL) that is used for needle implantation in the first layer. After selecting the best formulation, it was tested for in vitro release, ex vivo permeation, and in vivo pharmacokinetics to ensure its dependability. The mechanical strength and penetration of TDMN allow for cutaneous administration of RV. TDMN penetrated up to 4 layers of parafilm® and needle reduced < 10%, indicating strong mechanical strength. In in vitro and ex vivo drug release, TDMN distributes RV more continuously than the dissolving microneedle (DMN) as a control. After 168 hours, TDMN released 91.34 ± 11.39% RV, while control was 99.40 ± 0.47%. In ex vivo permeation, TDMN provides 2.606 ± 58.9 µg/cm2 RV, while control provides 32.111 ± 782.54 µg/cm2. TDMN sustained RV values of 0.54 ± 0.09 µg/mL and 1.23 ± 0.26 µg/g in plasma and brain throughout 168 hours of in vivo pharmacokinetic testing. Transdermal delivery using TDMN resulted in a 2-fold increase in brain concentration compared to oral administration in pharmacokinetic study, TDMN treatment showed significantly greater area under curve (AUC) and mean residence time (MRT) values than DMN, patch, and oral administration (p < 0.05).

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“…[3][4] Researcher akram et.al developed a wound dressing materials from betel leaf extraction by electrospinning technique. [5] To derive natural colors from discard, tulsi, gardenia yellow, Butea monosperma, black rice, leaves, plants, coral jasmine flower, Alkanna tinctoria roots, coral jasmine flower, and neem leaves, researchers performed studies. [6][7][8][9][10][11][12] In contrast to synthetic dyes, a greater quantity of natural dyes may be required to color a given quantity of fabric because natural color has the inherent tendency to discolor quickly.…”

Section: Introductionmentioning

confidence: 99%

Exploring Ultrasonic‐Assisted Extraction and Eco‐Friendly Dyeing of Organic Cotton using Syzygium cumini Leaf Extracts

Akram,

Uddin Banna,

Mahmud

et al. 2024

ChemistrySelect

Self Cite

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The demand for natural dyes is increasing due to the negative environmental impacts of synthetic color. In fact, customers are becoming more concerned about their health and the environmentally friendly products. The aim of this research is to disclose the dye extraction process using the ultrasonic method and eco‐friendly dyeing of organic cotton knitted fabric. Initially, 10 g of Syzyguim cumini leaf powder was dissolved in 150 mL of purified water maintaining a 1 : 15 M : L ratio to extract the color. After that, the extracted dye solution was added to coloration bath following the M : L ratios of 1 : 16, 1 : 12, and 1 : 8 for producing dark, medium, and light shades, respectively. Post mordanting was done using natural lemon juice for colorfastness improvement. The color attributes were revealed by the spectrophotometric analysis. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were used to comprehend the successful relationship that exists among SCL dyes and organic cotton fibers, and the TGA analysis confirmed that dyed fabric is more stable than undyed fabric. Moreover, the colored sample‘s pH, formaldehyde level, and presence of forbidden Azo groups (aromatic amines) were examined. The test results revealed that very good to excellent color fastness properties were obtained and no harmful chemicals were detected in the dyed samples.

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Fabrication and characterization of antimicrobial wound dressing nanofibrous materials by PVA-betel leaf extract

Cited by 11 publications

References 52 publications

Developing and Screening of a Bacteria-Fighting and Moisture-Controlling Coccinia grandis and Poly(vinyl alcohol) Electrospun Nanofibrous Mat

Developing and Screening of a Bacteria-Fighting and Moisture-Controlling Coccinia grandis and Poly(vinyl alcohol) Electrospun Nanofibrous Mat

Implantable Trilayer Microneedle Transdermal Delivery System to Enhance Bioavailability and Brain Delivery of Rivastigmine for Alzheimer Treatment: a Proof-of-concept Study

Exploring Ultrasonic‐Assisted Extraction and Eco‐Friendly Dyeing of Organic Cotton using Syzygium cumini Leaf Extracts

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