Fabrication and characterization of bilayer scaffolds made of decellularized dermis/nanofibrous collagen for healing of full-thickness wounds

Amini, Naser; Hivechi, Ahmad; Asadpour, Shiva; Ebrahimzadeh, Kaveh; Kargozar, Saeid; Gholipourmalekabadi, Mazaher; Nasrolahi, Ahvan; Ghasemian, Melina; Shafaat, Amir; Mozafari, Masoud; Milan, Peiman Brouki; Rezapour, Alireza

doi:10.1007/s13346-023-01292-0

Cited by 10 publications

(1 citation statement)

References 55 publications

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“…These membranes' capacity to accelerate wound closure and improve collagen deposition was demonstrated in vivo experiments on a mouse full-thickness wound model, underscoring their effectiveness in skin regeneration. For skin regeneration, Amini et al [72] introduced a unique biomimetic hybrid scaffold made of decellularized dermis and collagen fibers that included stromal cell-derived factor-1 alpha (SDF-1α). According to this study., the prolonged release of SDF-1α from the scaffold demonstrated a strong capacity to quicken wound healing in diabetic rat models, pointing to its potential for skin tissue engineering.…”

Section: In Vitro and In Vivomentioning

confidence: 99%

Collagen-Based Therapies for Accelerated Wound Healing

Ghofrani,

Hassannejad

2024

Cell and Molecular Biology - Annual Volume 2024 [Working Title]

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Wound healing is a complex and dynamic process essential for maintaining tissue integrity and functionality. As a key component of the extracellular matrix (ECM), Collagen plays a crucial role in orchestrating this regenerative process. Acting as a vital fibrous protein, collagen serves as a dynamic conductor, coordinating tissue regeneration and repair. This chapter explores the application of collagen in accelerating the wound healing process, starting with the fundamental role of collagen in ECM remodeling. It discusses how collagen promotes wound healing through different types of scaffolds, micro/nanoparticles, synthetic peptides, and interactions with extracellular vesicles (EVs). The chapter also delves into the regulatory function of collagen in cellular processes and evaluates strategies to stimulate collagen synthesis. In conclusion, it provides an overview of upcoming advancements in the dynamic field of collagen-based therapies for wound treatment.

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Section: In Vitro and In Vivomentioning

confidence: 99%