Fabrication and characterization of bioresorbable radiopaque PLLA/PCL/Mg alloy composite tubes for cardiovascular stent application

Srivastava, Alok; Kumari, Nisha; Agarwal, Mohit; Bhati, Pooja; Bhatnagar, Naresh

doi:10.1080/00914037.2023.2182783

Cited by 6 publications

(5 citation statements)

References 72 publications

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“…Unlike PLA, PCL shows high elongation at break, enhanced toughness, better thermal stability, slow degradation rate and low tensile strength 71–73 . It can form compatible blends with PLA, imparting shape memory, reducing the degradation kinetics, increasing crack resistance and improving dyeability 5,74–76 . However, the phase separation due to the immiscible gap between the polymers leads to finely dispersed submicron spherulites of PCL corresponding to “sea‐island” morphology.…”

Section: Biodegradable Pla/polymermentioning

confidence: 99%

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

Srivastava,

Bhati,

Singh

et al. 2024

Polymer Engineering & Sci

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Poly(lactic acid) (PLA) is one of the most promising biopolymers extensively used in food, packaging, medical and pharmaceutical industries. It is due to favorable physicochemical properties, in‐situ hydrolytic degradation and well‐established processing parameters. However, in medical engineering applications, PLA shows some drawbacks like low cell adhesion, biological inertness, slow degradation rate and high acid inflammation. These shortcomings of pure PLA could be addressed by blending it with other bioresorbable materials and compatibilizers. This review provides comprehensive information on different PLA composites in the field of tissue engineering, implants, injury management and drug delivery systems. The PLA‐based composites are divided into four parts: PLA/polymer, PLA/metal, PLA/ceramic, and PLA/nanoparticles. It also investigates various synthesis process, role of different compatibilizers, in vitro studies and their in vivo applications.Highlights Review the trends of bioresorbable PLA blends/composites. Extensively focused on PLA blend with polymer, metal, ceramic, and nanoparticles. Role of reinforcement and compatibilizer to overcome shortcomings of PLA implant. Highlights advantages, limitations, and properties of different types of PLA implants. Discuss various clinical applications and future of PLA blends/composite scaffolds.

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Section: Biodegradable Pla/polymermentioning

confidence: 99%

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

Srivastava,

Bhati,

Singh

et al. 2024

Polymer Engineering & Sci

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“…Detailed comparison studies on both the BAE tube materials already been performed for cardiovascular stent application. 22,24,25…”

Section: Tube Extrusionmentioning

confidence: 99%

“…Since the glass transition temperature (T g ) of the PLLA/PCL matrix was 63 C, hence the crimping temperature should be lower as it can lead to plastic deformation. 22 On the other side, the stent was compressed above the body temperature to reduce the chance of physical damage and release the stored residual stress.…”

Section: Radial Recoil After Compressionmentioning

confidence: 99%

“…Since, during crimping, the back stresses accumulate near the reinforcement particles resist the upcoming stress. 22,30 Hence, it increases the stress response, where it requires extra effort to overcome the resisting stress.…”

Section: Cyclic Radial Compression Loadingmentioning

confidence: 99%

“…Additionally, the radiopaque nature of the composite helps to locate the implant position and monitor the endothelization rate. [22][23][24] In this work, BAE tubes of PLLA/PCL(5%)/BRM(5%) composite and PLLA/PCL(5%) polymer were cut on the optimized FSLM parameters for producing cardiovascular stents. These composite and polymeric stents were assessed for different mechanical properties required for angioplasty, like radial strength, crimping parameter, expansion process, recoil, foreshortening, and behavior under cyclic loading and unloading.…”

mentioning

confidence: 99%

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Fabrication and characterization of PLLA/PCL/Mg‐Zn‐Y alloy composite stent

Srivastava,

Singh,

Agrawal

et al. 2023

Polymer Engineering & Sci

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Bioresorbable polymeric stents (BPS) can become a promising alternative over permanent stents, as it reduce in‐stent thrombosis, endothelial dysfunction, and thrombogenicity. Although, a few limitations like uncontrolled degradation, inadequate strength, and lack of radiopacity restrict its application. Thus, a novel bioresorbable radiopaque Mg‐Zn‐Y Alloy (BRM) of high effective atomic number (Zeff) was developed to reinforce and attenuate X‐rays in the polymers. After that, the optimized BRM microparticles were blended with radiolucent poly (L‐lactide)/poly (ε‐caprolactone) (PLLA/PCL) polymer and extruded into biaxially expanded (BAE) tubes. Further, in this work, BAE tubes of PLLA/PCL/BRM and PLLA/PCL were cut using the optimized Femtosecond laser machine (FSLM) parameters for fabricating cardiovascular stents. These stent materials were assessed to sustain the angioplasty procedure, such as radial strength, crimping, recoil, expansion process, and performance under cycling loading.Highlights A novel biodegradable radiopaque Mg‐Zn‐Y alloy was developed. Adding Mg alloy (5% wt.) in PLLA/PCL imparts X‐ray visibility. Composite stents show better compressive radial strength and flexibility. It also reveals low crimping recoil, expansion recoil, and foreshortening. Composite stents can withstand arterial vasomotion better than PLLA/PCL.

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Integrating extrusion process and additive manufacturing for biomedical breakthroughs

Sharma,

Mudgal,

Gupta

2023

Int J Interact Des Manuf

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Fabrication and characterization of bioresorbable radiopaque PLLA/PCL/Mg alloy composite tubes for cardiovascular stent application

Cited by 6 publications

References 72 publications

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

Fabrication and characterization of PLLA/PCL/Mg‐Zn‐Y alloy composite stent

Integrating extrusion process and additive manufacturing for biomedical breakthroughs

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