Fabrication and Characterization of Curcumin-Loaded Complex Coacervates Made of Gum Arabic and Whey Protein Nanofibrils

Mohammadian, Mehdi; Salami, Maryam; Alavi, Farhad; Momen, Shima; Emam‐Djomeh, Zahra; Moosavi-Movahedi, Ali Akbar

doi:10.1007/s11483-019-09591-1

Cited by 37 publications

(31 citation statements)

References 24 publications

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“…Nanocomplexation with food biopolymers was introduced to improve the solubility, stability, absorption, and bioavailability of hydrophobic bioactive compounds such as curcumin. 16 Curcumin can form complexes with carriers through hydrophobic interactions. Hydrogen bonds may also contribute to nanocomplex formation.…”

Section: Nanocomplexationmentioning

confidence: 99%

“…Curcumin-protein nanocomplexes may be used as dispersions or converted into powders by freezing for further use. 16 In a study conducted by Tapal and Tiku, 5 who studied soy protein complexation effects on curcumin solubility, they reported that curcumin's aqueous solubility increased 812-fold through soy protein nanocomplexing. Moreover, the complexation improved the stability and antioxidant activity of curcumin.…”

Section: Nanocomplexationmentioning

confidence: 99%

“…7 Whey protein nanofibrils have been used as a carrier for curcumin by nano-complexing. 135 Mohammadian et al 16 reported significantly increased curcumin aqueous solubility by binding to nanofibrils. These nanofibrils were prepared by heating the acidic whey protein solution.…”

Section: Nanocomplexationmentioning

confidence: 99%

“…Nanofibrils' high ability to load curcumin was due to their high surface hydrophobicity. 16 The results of antioxidant capacity quantities (DPPH radical scavenging activity and lowering power) suggested that curcumin's antioxidant activity was improved through nanofibril complexation. 135 Evaluating in vitro curcumin release from nano-complexes under simulated gastrointestinal conditions revealed that curcumin was slowly released from the nanocomplexes.…”

Section: Nanocomplexationmentioning

confidence: 99%

“…5 Curcumin also has a high rate of metabolism and low gastrointestinal absorption in the body. 15,16 It may be damaged during processing and under gastrointestinal conditions, thus reducing its bioavailability. 17 However, curcumin is stable in systems with low physiological pH and acidic conditions but breaks down quickly and has poor photostability under alkaline conditions.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

et al. 2021

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Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as an aromatic stimulant, a food preservative, and coloring material. The commonly used names of turmeric are castor saffron, turmeric, and saffron root. Turmeric is a yellow-orange polyphenolic natural substance derived from C. longa rhizomes. It has been used to treat common inflammatory diseases, tumors, biliary diseases, anorexia, cough, topical wounds, diabetic injuries, liver disorders, rheumatism, and sinusitis. Extensive studies on the biological properties and pharmacological consequences of turmeric extracts have been conducted in recent years. Curcumin, the primary yellow biocomponent of turmeric, has anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic, antibacterial, antiprotozoal, antiviral, antifibrotic, immunomodulatory, and antifungal properties. Defense assessment tests showed that curcumin is tolerated well at high doses, without adverse effects. Thus, curcumin is a highly active biological material with the potential to treat different diseases in modern medicine. This review article focuses on curcumin's biological characteristics. The most popular methods for curcumin encapsulation are also discussed. Several effective techniques and approaches have been proposed for curcuminoid capsulation, including nanocomplexing, gelation, complex coacervation, electrospraying, and solvent-free pH-driven encapsulation. This review also highlights curcumin's chemical properties, allowing the readers to expand their perspectives on its use in the development of functional products with health-promoting properties.

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Section: Nanocomplexationmentioning

confidence: 99%

Section: Nanocomplexationmentioning

confidence: 99%