Fabrication and characterization of dual-responsive nanocarriers for effective drug delivery and synergistic chem-photothermal effects

Lv, Ruihong; Song, Shuhui; Wang, Haohao; Gao, Shanshan; Zhang, Shanshan; An, Yingli; Zhou, Hongying; Ji, Yongsheng; Xu, Zhigang

doi:10.1016/j.colsurfa.2022.130256

Cited by 7 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[52] As a natural photothermal agent, PDA-mediated the mild-temperature PTT (< 45 °C) was achieved by regulating the ratio and reaction time of nanocarriers and PDA, forming the foundation for chemophotothermal synergistic enhanced tumor treatment. [53] In vitro drug release…”

Section: Photothermal Performancementioning

confidence: 99%

Co‐delivery of Curcumin and Doxorubicin Using a pH‐photothermal Dual‐responsive and CD44‐targeted Nanocarrier for Enhanced Chemo‐photothermal Synergistic Tumor Treatment

Lv,

Wang,

et al. 2023

ChemNanoMat

Self Cite

View full text Add to dashboard Cite

In this study, we have developed a novel approach for synergistic tumor treatment by utilizing degradable dendritic mesoporous silica nanoparticles loaded with doxorubicin and curcumin (Cur). These nanoparticles are equipped with polydopamine (PDA) for photothermal therapy and hyaluronic acid (HA) as a targeting ligand. The incorporation of PDA not only ensures the controlled release of therapeutic agents but also confers pH and photothermal responsiveness to the nanocarriers. Cur, a natural compound, serves as an antitumor sensitizer, elevating intracellular ROS levels to promote apoptosis. In addition, the excellent biocompatibility and targeting property of nanocarriers were enhanced by the HA‐modification, improving the effective accumulation in tumor cells. Comprehensive research including MTT assay, live/dead staining and ROS generation proved that the excellent antitumor capability of dual‐drug loaded nanocarriers was a result of chemo‐photothermal synergistic therapy and Cur‐induced cellular amplified ROS generation. The cellular uptake assays further demonstrated the efficiency of HA‐mediated intracellular accumulation, accelerated uptake driven by photothermal‐induced and a precise internalization pathway of nanocarriers. Furthermore, the results of in vivo biocompatibility revealed no significant blood and organ toxicity associated to the prepared nanocarriers. Our findings underscore the substantial potential of the proposed dual‐drug loaded nanocarriers for chemo‐photothermal synergistic therapy, offering a safe and promising strategy for effective tumor treatment.

show abstract

Section: Photothermal Performancementioning

confidence: 99%

Co‐delivery of Curcumin and Doxorubicin Using a pH‐photothermal Dual‐responsive and CD44‐targeted Nanocarrier for Enhanced Chemo‐photothermal Synergistic Tumor Treatment

Lv,

Wang,

et al. 2023

ChemNanoMat

Self Cite

View full text Add to dashboard Cite

show abstract

“…A common method to increase the hydrophilicity of PCL scaffolds is to coat them with polydopamine (PDA). , PDA adheres to nearly all substrates, including polymers, metals, and inorganics. PDA has a high photothermal conversion efficiency, meaning that under low-laser power density and short irradiation periods, it can kill cancer cells effectively with little harm caused to healthy tissues. , …”

Section: Introductionmentioning

confidence: 99%

“…PDA has a high photothermal conversion efficiency, 24 meaning that under low-laser power density and short irradiation periods, it can kill cancer cells effectively with little harm caused to healthy tissues. 25,26 The photothermal effects of PDA have been gaining a great deal of attention for bone cancer therapy. For instance, a previous study found that loaded drug SN38 into alendronateconjugated PDA nanoparticles and the combined photothermal chemotherapy effectively suppressed tumors' progress.…”

Section: Introductionmentioning

confidence: 99%

Strategically Designed Bifunctional Polydopamine Enwrapping Polycaprolactone-Hydroxyapatite-Doxorubicin Composite Nanofibers for Osteosarcoma Treatment and Bone Regeneration

Rezk,

Lee,

Kim

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

This study presents a new multifunctional nanofibrous drug delivery system to provide effective combination therapy with enormous potential for the treatment of osteosarcoma. We developed a composite nanofiber scaffold comprising poly(ε-caprolactone) (PCL) and hydroxyapatite (HAp)-loaded doxorubicin (DOX) coated with polydopamine (PDA) to combine cancer cell inhibition with bone tissue regeneration. DOX was conjugated with HAp and then mixed with a PCL solution to prepare a PCL/ HAp−DOX (labeled PCLDH) nanofiber. Then, in situ polymerization of PDA on the PCLDH occurred to produce the PCLDH@PDA composite nanofiber. The morphology, XRD, FT-IR, wettability, photothermal characteristics, cumulative drug release, and in vitro bioactivities were evaluated. We found that the PDA coating not only enhanced the hydrophilic properties but also controlled drug release. The PCLDH@PDA composite scaffold significantly suppressed the proliferation of bone cancer cells initially and, consequently, improved the adhesion and proliferation of human mesenchymal stem cells (hMSCs). The PDA coating boosted the composite scaffold's bioactivity, as demonstrated through ALP activity, ARS assay, and biomineralization results. This strategy offers a promising dual-function scaffold to treat residual cancer and reconstruct defects after osteosarcoma surgery.

show abstract

“…Ordinary hydrogels can release drugs slowly, but the speed and dosage of drug release are uncontrollable [ 21 ]. In contrast, stimuli-responsive hydrogels can be loaded with drugs to achieve controllable release of drugs under endogenous microenvironmental stimulation (such as mildly acidic pH, hypoxia, high glutathione (GSH) and overexpression of specific enzymes) or exogenous physical stimulation (e.g., light, temperature, magnetism and ultrasound) [ [22] , [23] , [24] , [25] , [26] ]. In particular, disulfide bonds have been extensively explored for the development of redox-responsive hydrogels [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

In situ forming an injectable hyaluronic acid hydrogel for drug delivery and synergistic tumor therapy

Fan,

Liu,

Dong

et al. 2024

Heliyon

View full text Add to dashboard Cite

Fabrication and characterization of dual-responsive nanocarriers for effective drug delivery and synergistic chem-photothermal effects

Cited by 7 publications

References 55 publications

Co‐delivery of Curcumin and Doxorubicin Using a pH‐photothermal Dual‐responsive and CD44‐targeted Nanocarrier for Enhanced Chemo‐photothermal Synergistic Tumor Treatment

Co‐delivery of Curcumin and Doxorubicin Using a pH‐photothermal Dual‐responsive and CD44‐targeted Nanocarrier for Enhanced Chemo‐photothermal Synergistic Tumor Treatment

Strategically Designed Bifunctional Polydopamine Enwrapping Polycaprolactone-Hydroxyapatite-Doxorubicin Composite Nanofibers for Osteosarcoma Treatment and Bone Regeneration

In situ forming an injectable hyaluronic acid hydrogel for drug delivery and synergistic tumor therapy

Contact Info

Product

Resources

About