Fabrication and Characterization of Electrospun  PCL-MgO-Keratin-Based Composite Nanofibers for  Biomedical Applications

BackgroundIn this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application.ResultsThe effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150 nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability.ConclusionsComposite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail.

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“…It depends on the properties of material added. Different type of materials and concentration values can give different results [45]. …”

Section: Resultsmentioning

confidence: 99%

Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications

et al. 2017

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“…The unique antimicrobial properties as well as protein release mechanisms of SiO 2 make the electrospun polymer-silicate hybrid NFs a candidate for wound dressing applications [82]. Suitable mechanical properties and positive magnesium release from PCL/MgO/Keratin NFs have been developed the composite materials with structural and material properties that will support biomedical applications and musculoskeletal tissue engineering [152]. The potential use of the electrospun PLA/Al 2 O 3 NFs for biomedical application was investigated by Kurtycz et al [87].…”

Section: Applications Of Ceramic Electrospun Matsmentioning

confidence: 99%

Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications

2017

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Ceramic nanofibers (NFs) have recently been developed for advanced applications due to their unique properties. In this article, we review developments in electrospun ceramic NFs with regard to their fabrication process, properties, and applications. We find that surface activity of electrospun ceramic NFs is improved by post pyrolysis, hydrothermal, and carbothermal processes. Also, when combined with another surface modification methods, electrospun ceramic NFs result in the advancement of properties and widening of the application domains. With the decrease in diameter and length of a fiber, many properties of fibrous materials are modified; characteristics of such ceramic NFs are different from their wide and long (bulk) counterparts. In this article, electrospun ceramic NFs are reviewed with an emphasis on their applications as catalysts, membranes, sensors, biomaterials, fuel cells, batteries, supercapacitors, energy harvesting systems, electric and magnetic parts, conductive wires, and wearable electronic textiles. Furthermore, properties of ceramic nanofibers, which enable the above applications, and techniques to characterize them are briefly outlined.

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“…For this purpose, the poly(3‐hydroxybutylate‐ co −3‐hydroxyvalerate) PHBV/keratin composite nanofibrous mats were fabricated using electrospinning technique and investigated as wounding dressing . Both poly(ε‐caprolactone) PCL/keratin and poly(lactic acid) PLA/keratin composite nanofibrous mats were also prepared by the same method and applied to biomedical and filterable applications . In addition to these synthetic biodegradable polymers.…”

Section: Introductionmentioning

confidence: 99%

Tunable wettability and tensile strength of chitosan membranes using keratin microparticles as reinforcement

Chen

Qiao

et al. 2016

J of Applied Polymer Sci

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Keratin particles with microscale are prepared by ball mill and its influences on the chitosan membrane is evaluated. Composite membranes with various content of keratin are fabricated, and their physical and chemical properties such as morphology, wettability, crystallization, thermal stability, tensile strength, and break elongation are investigated. Optical microscope and situ topographic scan mode of nano‐test system are used to examine the dispersion and aggregation of keratin on the surface of chitosan membrane. The result of contact angle (CA) and mechanical testing show that the incorporation of keratin particles decrease the CA from 98.1° to 58.2°. Tensile strength and break elongation of the composite membrane reaches a maximum of 65 ± 8 MPa and 15% when the keratin content is 6%, an increase of 80% and 88% compared with the pristine chitosan membrane. Both the increase in tensile strength and break elongation is result of the incorporation of keratin particles known for their excellent compatibility between keratin and chitosan matrix. These kind of composite material combines the antibacterial properties of chitosan with cell culture preference of keratin which may have potential biomedical application. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44667.

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Fabrication and Characterization of Electrospun PCL-MgO-Keratin-Based Composite Nanofibers for Biomedical Applications

Cited by 79 publications

References 38 publications

Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications

Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications

Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications

Tunable wettability and tensile strength of chitosan membranes using keratin microparticles as reinforcement

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