In multi-detector computed tomography (MDCT) abdominal and pelvic CT treatments with intravenous (IV) contrast media (CM), automated bolus monitoring with a fixed contrast enhancement delay was examined. Statistics assess all contrast enhancement variables, including patient data like body weight, cardiac output, and contrast injection settings. This study comprised 100 retrospective and 43 prospective patients. In the first group, the Hounsfield unit (HU) was measured before, 30 seconds, and 70 seconds after CM. The second group measured age, weight, heart rate, systolic and diastolic blood pressure, and creatinine. The radiographer computed CM time based on HU values around 120. The differences in HU levels across groups were used to create an equation for imaging time prediction utilizing auto-mated bolus monitoring. The Bolus Time Equation’s predictors included patient weight, heart rate, creatinine level, and systolic blood pressure, with 34.9% dependency and 59.1% influence on each variable. The equation is trustworthy since the ANOVA test indicated p = 0.002. The computation and study gave the same Bolus Time value with a p-value of (0.992 > 0.05). The first and second groups exhibited very different HU rates (p-value 0.00). The research found that fixed-time improved more than bolus monitoring, which performed better.