Fabrication and characterization of injection molded multi level nano and microfluidic systems

Matteucci, M.; Christiansen, Thomas; Tanzi, Simone; Østergaard, Peter Friis; Larsen, Simon Tylsgaard; Taboryski, Rafael J.

doi:10.1016/j.mee.2013.01.060

Cited by 30 publications

(36 citation statements)

References 19 publications

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“…In order to balance between the requirements of hydrodynamic resistance and of delivery of the optical power, overlap of deep channels and removal of solid wall separation are required. This marks a difference with previous work [22,23]: in order to precisely overlap deep channels with slight difference in depth, a modified multilayer process is required. The reason is that once a deep channel is dry etched into silicon, the spin coating of a uniform layer of resist for an aligned UV exposure is not possible due to the resist entering the deep channel.…”

Section: Discussionmentioning

confidence: 84%

“…Bonding was performed with lids ranging in thicknesses from 100 µm to 2 mm before the insertion and gluing of the fibers. Not only did the placement of the fibers after chip sealing provide a simplified alternative assembly but the bonding of thicker lids makes it possible to have systems with resistance to higher pressures (up to 9 bar with a 100 µm lid) [23]. Thanks to this feature, the filling time of the HC fiber can be reduced down to few minutes, which will be important for the feasibility of a sensor development.…”

Section: Discussionmentioning

confidence: 99%

“…The multilayer stamp (shim) for injection molding was fabricated with standard cleanroom techniques [22,23,27], these references also describe further details of the shim fabrication and polymer injection molding process. The mask-design is available in the Supplementary Information.…”

Section: Chip Fabrication and Assemblymentioning

confidence: 99%

“…The chip was then sealed either by thermal bonding of a TOPAS 5013 foil [23] or by gluing of a commercially available poleolefin foil (900320 by HJ-Bioanalytik, Erkelenz, Germany). While the poleolefin foil was found to be enough for the low pressures required by the optical stretching experiments, a tighter seal was required to inject liquid inside the hollow core fibers.…”

Section: Chip Fabrication and Assemblymentioning

confidence: 99%

“…While the poleolefin foil was found to be enough for the low pressures required by the optical stretching experiments, a tighter seal was required to inject liquid inside the hollow core fibers. Thermally-bonded chips of TOPAS 5013 were able to withstand up to 900 kPa of pressure [23], for this reason the thermal bonding was preferred to the poleolefin foil gluing in the chips dedicated to Raman spectroscopy measurements. The complete process (waveguide insertion and bonding) lasts typically between 60 and 90 min including fiber preparation (5-10 min), insertion and gluing of the fibers (20-30 min), glue curing (30 min), and thermal bonding of the lid (10-20 min).…”

Section: Chip Fabrication and Assemblymentioning

confidence: 99%

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Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

et al. 2015

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Abstract:We present a method to fabricate polymer optofluidic systems by means of injection molding that allow the insertion of standard optical fibers. The chip fabrication and assembly methods produce large numbers of robust optofluidic systems that can be easily assembled and disposed of, yet allow precise optical alignment and improve delivery of optical power. Using a multi-level chip fabrication process, complex channel designs with extremely vertical sidewalls, and dimensions that range from few tens of nanometers to hundreds of microns can be obtained. The technology has been used to align optical fibers in a quick and precise manner, with a lateral alignment accuracy of 2.7˘1.8 µm. We report the production, assembly methods, and the characterization of the resulting injection-molded chips for Lab-on-Chip (LoC) applications. We demonstrate the versatility of this technology by carrying out two types of experiments that benefit from the improved optical system: optical stretching of red blood cells (RBCs) and Raman spectroscopy of a solution loaded into a hollow core fiber. The advantages offered by the presented technology are intended to encourage the use of LoC technology for commercialization and educational purposes.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Chip Fabrication and Assemblymentioning

confidence: 99%

Section: Chip Fabrication and Assemblymentioning

confidence: 99%

Section: Chip Fabrication and Assemblymentioning

confidence: 99%

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Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

et al. 2015

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Design of Electrochemical Microfluidic Detectors: A Review

Díaz-Real

Holm

2021

Adv Materials Technologies

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Miniaturized electrochemical systems integrated into microfluidic flow devices have been an active research field the last couple of decades. This has resulted in many advanced microfluidic platforms for the conversion and detection of chemicals. The development is partly driven by the increased access to and decreased cost of fabrication. In the design of microfluidic electrochemical cells, several aspects need to be handled, such as the accurate control of potential, electrolyte flow, pH, pressure, and temperature. This can be further complicated by integrating photon traffic for spectro(electro)chemical detection. Here, a comprehensive review of recent advances and approaches to the design of microfluidic flow devices for detection is presented, first dealing with the design of electrodes and flow pathways, then highlighting some common challenges and how these have been dealt with in the literature. This work aims to be a guide for researchers in the design of microfluidic electrochemical systems for detection of chemical species.

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Comparative study of the parameters affecting the performance of microchannels' heat exchangers: Latest advances review

Asim

Shoaib

Uddin

et al. 2023

Energy Science & Engineering

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Microchannel heat exchangers are heat exchangers with a tube diameter of less than 1 mm. Conventional cooling approaches such as the forced‐air cooling technique fail in high technological compact systems because of the small‐sized surfaces of chips and circuits. In comparison, microchannel heat exchangers are being extensively utilized in compact‐sized devices where a high heat‐transfer medium is required. Moreover, consumers' continued desire for compact products has prompted researchers to study microchannel heat exchangers for their ability to boost the rate of heat transfer that ensures the safety of compact designs. This study presents the evaluation of performance parameters and the manufacturing aspects of microchannel heat exchangers. This study also examines how microchannel heat exchangers are affected by several parameters, including the type of working fluid used, Brownian motion, geometry of the channel, Reynolds number, Nusselt number, Knudsen number, wall resistance of the channel, the effect of gravity, and inlet and outlet arrangement for fluid. Investigating the various geometries for the microchannel indicates that the least pressure drop occurs in square shape cross‐section channels while the highest pressure drop occurs in channels with triangular cross‐sections. Moreover, it has been observed that, with the addition of nanoparticles to the working fluid, the thermal properties of the exchangers as well as the pressure drop increases while at the same time it reduces the boundary layer thickness. In addition, the Reynolds number affects the performance irrespective of the channel geometry. When the fluid is added with nanoparticles, like, Al2O3 and copper oxide (CuO) with different volumetric fractions (φ) of 0%, 0.5%, 1%, 1.5%, and 2%, the performance of the microchannel rises with rising the Reynolds number but conversely when the fluid is used in pure form the performance decreases with the rising value of Reynolds number. In addition, it has been observed that the overall improvement is obtained at φ = 2% and Re = 100 for CuO–water nanofluid. Apart from this, the least heat transfer is recorded at φ = 0.5% and Re = 1.00 for both nanofluids. Moreover, this study concludes that the Nusselt number is independent of the Reynolds number in the regime of laminar flow. It is further evident that as the nanoparticle size reduces, the Nusselt number rises when all the remaining conditions are the same. Apart from this, investigating the inlet/outlet arrangement through finite volume method for D‐, I‐, N‐, S‐, U‐, and V‐type arrangements, it is evident that the V‐type sink has overall greater performance. In terms of gravity, it is observed that it has no effect on the performance of microchannel heat exchangers. This study further illustrates the effects of the fabrication method on the performance of the microchannel heat exchangers.

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Fabrication and characterization of injection molded multi level nano and microfluidic systems

Cited by 30 publications

References 19 publications

Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

Design of Electrochemical Microfluidic Detectors: A Review

Comparative study of the parameters affecting the performance of microchannels' heat exchangers: Latest advances review

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