Fabrication and Characterization of  &lt;i&gt;Sargassum Glaucescens&lt;/i&gt; Extract (SGE) Embedded in Marine-Derived Collagen for Burn Wound Healing

Gharahgheshlagh, Soheila Naderi; Ghadimi, Tayyeb; Latifi, Noorahmad; Hivechi, Ahmad; Sarmadi, Vahid Hosseinpour; Shahbazi, Sina Bayat; Amini, Naser; Milan, Peiman Brouki; Forghani, Siamak Farokh; Abbaszadeh, Abolfazl; Larijani, Ghazaleh; Fathalian, Hamid; Mortazavi, Shokoufeh; Latifi, Fatemeh; Ghadimi, Fatemeh

doi:10.2139/ssrn.4110907

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“…The findings of the current study are in agreement with the former study, which showed that the fish Col embedded with Sargassum glaucescens extract accelerates the wound healing rate. [ 53 ] According to Veeruraj et al., astaxanthin‐incorporated Col film exhibited significant wound healing activity, which was supported by a significantly enhanced the rate of wound contraction. [ 52 ]…”

Section: Resultsmentioning

confidence: 99%

The Effect of Rainbow Trout (Oncorhynchus mykiss) Collagen Incorporated with Exo‐Polysaccharides Derived from Rhodotorula mucilaginosa sp. on Burn Healing

Ghadimi

Gharahgheshlagh

Latifi

et al. 2023

Macromolecular Bioscience

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Burn is one of the physically debilitating injuries that can be potentially fatal; therefore, providing appropriate coverage in order to reduce possible mortality risk and accelerate wound healing is mandatory. In this study, collagen/exo‐polysaccharide (Col/EPS 1–3%) scaffolds are synthesized from rainbow trout (Oncorhynchus mykiss) skins incorporated with Rhodotorula mucilaginosa sp. GUMS16, respectively, for promoting Grade 3 burn wound healing. Physicochemical characterizations and, consequently, biological properties of the Col/EPS scaffolds are tested. The results show that the presence of EPS does not affect the minimum porosity dimensions, while raising the EPS amount significantly reduces the maximum porosity dimensions. Thermogravimetric analysis (TGA), FTIR, and tensile property results confirm the successful incorporation of the EPS into Col scaffolds. Furthermore,the biological results show that the increasing EPS does not affect Col biodegradability and cell viability, and the use of Col/EPS 1% on rat models displays a faster healing rate. Finally, histopathological examination reveals that the Col/EPS 1% treatment accelerates wound healing, through greater re‐epithelialization and dermal remodeling, more abundant fibroblast cells and Col accumulation. These findings suggest that Col/EPS 1% promotes dermal wound healing via antioxidant and anti‐inflammatory activities, which can be a potential medical process in the treatment of burn wounds.

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Section: Resultsmentioning

confidence: 99%