Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications

Ghafari, Robab; Jonoobi, Mehdi; Amirabad, Leila Mohammadi; Oksman, Kristiina; Taheri, Ahmad Reza

doi:10.1016/j.ijbiomac.2019.06.104

Cited by 96 publications

(42 citation statements)

References 34 publications

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“…The obtained results suggested that these alginatechitosan aerogel fibres could be good candidates for wound healing applications (Batista et al, 2020). (Ghafari et al, 2019).…”

Section: The E X Ample S Of Med I C Al Appli C Ati On S Of B I Oba mentioning

confidence: 86%

“…As a result of this study, the author suggested that biobased aerogels can be used of a tissue scaffold for the formation of new viable tissue (e.g. blood vessels, bone, cartilage, skin, bladder and muscle) for a medical purpose (Ghafari et al, 2019).…”

Section: The Examples Of Medical Applications Of Biobased Aerogelsmentioning

confidence: 99%

“…Due to their common functionalities (bioactivity, biocompatible, biodegradability, environmentally friendly), biobased aerogels provide a vast capacity in the field of interdisciplinary and multidisciplinary scientific research. They are used for thermal insulation, tissue engineering, regenerative medicine, drug delivery systems, functional foods, as catalysts, sensors and cosmetic applications (Athamneh et al, 2019; Batista et al, 2020; García‐González et al, 2015; Ghafari et al, 2019; Goncalves et al, 2016; Horvat et al, 2017; López‐Iglesias et al, 2019; Lovskaya et al, 2015; Lu et al, 2014; Lu et al, 2014; Najberg et al, 2020; Ulker & Erkey, 2014; Valo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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The medical applications of biobased aerogels: ‘Natural aerogels for medical usage’

Okutucu

2021

Med Devices & Sens

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Increasing demand for products made from sustainable and non-petroleum-based resources is a major driving force for the development of environmentally friendly green materials. With the development of sol-gel materials, the aerogels can become a good alternative material. Aerogels are sol-gel materials obtained by replacing the solvent in the meshes of a gel network with air. Aerogels are about 95% air so that they are very light in weight and have high porosity. The average densities of aerogels are 0.003-0.15 kg/m 3 , and the surface areas are 500-1000 m 2 /g (Smirnova & Gurikov, 2018). The aerogels can be distinguished from other porous biomaterials by structural properties

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“…The obtained results suggested that these alginatechitosan aerogel fibres could be good candidates for wound healing applications (Batista et al, 2020). (Ghafari et al, 2019).…”

Section: The E X Ample S Of Med I C Al Appli C Ati On S Of B I Oba mentioning

confidence: 86%

Section: The Examples Of Medical Applications Of Biobased Aerogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The medical applications of biobased aerogels: ‘Natural aerogels for medical usage’

Okutucu

2021

Med Devices & Sens

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“…Mahumane et al [ 105 ] suggested that the tissue scaffold should be designed with pores that are small enough to support three dimensions of cell–cell contacts and at the same time large enough to allow nutrients, oxygen, and bioactive factor diffusion to ensure the survival and growth of cells. Many studies reported the ability to control the porosity and the pore size of biopolymer-based aerogels; pore sizes between 20 and 160 μm were adequate for cell growth, proliferation, and colonization [ 105 , 106 ]. The unique biological properties and the ability to customize the scaffold architecture have made the biopolymeric aerogels of great interest among researchers in the past few years to develop novel solutions for many tissue defects.…”

Section: Biopolymer-based Aerogels In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

“…Tissue scaffolds should permit the transport of needed oxygen, nutrients, and growth factors for the growth, attachment, proliferation, and differentiation of cells. Some biopolymeric scaffolds have been reported to enhance the attachment of cells to the scaffold and stimulate cell–biomaterial attachment, growth, and migration [ 106 , 109 ]. A variety of methods has been used in aerogel tissue scaffold fabrication.…”

Section: Biopolymer-based Aerogels In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.

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Applications of Nanocellulose in Tissue Engineering and Tissue Grafting

Dey,

Singh,

Sarkar

et al. 2024

Nanocellulose

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Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications

Cited by 96 publications

References 34 publications

The medical applications of biobased aerogels: ‘Natural aerogels for medical usage’

The medical applications of biobased aerogels: ‘Natural aerogels for medical usage’

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Applications of Nanocellulose in Tissue Engineering and Tissue Grafting

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