Fabrication and characterization of novel microneedles made of a polystyrene solution

Luangveera, Wangtan; Jiruedee, S.; Mama, Wijuk; Chiaranairungroj, Muthita; Pimpin, Alongkorn; Palaga, Tanapat; Srituravanich, Werayut

doi:10.1016/j.jmbbm.2015.06.009

Cited by 34 publications

(18 citation statements)

References 20 publications

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“…The biocompatible materials and the fabrication method lend the polymer MNs themselves to be safe, inexpensive, and easy for mass production. In recent years, various biodegradable polymers have been used in the development of solid MNs and applied to the pretreatment of the skin, such as polystyrene, 27 polyvinyl pyrrolidone, 28 polycarbonate, 29 photoresist (SU-8) resin 30 and so on. There have been made a progress in enhancing drug delivery with solid MNs for skin pretreatment.…”

Section: Introductionmentioning

confidence: 99%

A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin

et al. 2017

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Section: Introductionmentioning

confidence: 99%

A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin

et al. 2017

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“…There are five principal classes of microneedle used for drug delivery applications: solid, drug coated solid, hollow, dissolvable, and swellable [1][2][3][8][9][10][11][12][13][14][15][16][17][18][19]. The fabrication of solid MN arrays is procedurally the simplest approach and can be constructed from a variety of conventional and inexpensive polymers such as polystyrene, polycarbonate, and polymethylmethacrylate [8][9][10][11][12].…”

Section: Resultsmentioning

confidence: 99%

“…The fabrication of solid MN arrays is procedurally the simplest approach and can be constructed from a variety of conventional and inexpensive polymers such as polystyrene, polycarbonate, and polymethylmethacrylate [8][9][10][11][12]. Such polymers enable the acquisition of mechanically robust arrays that can withstand repeated handling by inexpert users, but the retention of the "sharp" aspect can inadvertently present a needlestick hazard where such devices are carelessly discarded within the workspace.…”

Section: Resultsmentioning

confidence: 99%

Microneedle Manufacture: Assessing Hazards and Control Measures

Martin

McConville

Anderson

et al. 2017

Safety

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Transdermal microneedles have captured the attention of researchers in relation to a variety of applications, and silicone-based moulds required to produce these systems are now widely available and can be readily manufactured on the lab bench. There is however some concern over the potential for accidental needlestick injuries and, as with any sharp hazard, the potential for blood-borne pathogen transmission must be considered. This follows from recent governmental concerns over the use of microneedle systems in dermabrasion. Despite the piercing nature of the microneedle patch sharing many similarities with conventional hypodermic needles, there are notable factors that mitigate the risk of contamination. A range of microneedle systems has been prepared using micromoulding techniques, and their puncture capability assessed. A critical assessment of the potential for accidental puncture and the control measures needed to ensure safe utilisation of the patch systems is presented.

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“…Besides the above methods, micromolding can also be used. For instance, PS can be dissolved in toluene and then cast into the negative mold . This process avoids high temperature but raises a safety concern because there might have some residue of the toxic solvent left in the MNs.…”

Section: Polymeric Microneedlesmentioning

confidence: 99%

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Chang

Zheng

Chew

et al. 2020

Adv Materials Technologies

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These MN platforms have been intensively explored for transdermal drug delivery in the treatment of both local and systemic diseases. [1c,12] They function as carriers for small molecular drugs, [13] peptides and proteins (e.g., insulin, vaccines, and antibodies), [8a,14] oligonucleotides, [11d] and nanomedicines [10a,b] and deliver them into peripheral tissues like skin, eyes, mouth, vascular wall, vagina etc. [15] Recently, MNs also receive attention from medical diagnosis and health monitoring, as they can easily access skin interstitial fluid (ISF) that is formed by blood transcapillary filtration and contains numerous biomarkers of clinical interest. [16] They can either directly sample ISF for postanalysis, [9e,11b,17] or integrate with sensing components for in situ real-time monitoring. [18] This article summarizes the recent advances in the MN field including the design, fabrication, and biomedical applications (Figure 1). The challenges and future perspectives are also discussed.

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Fabrication and characterization of novel microneedles made of a polystyrene solution

Cited by 34 publications

References 20 publications

A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin

A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin

Microneedle Manufacture: Assessing Hazards and Control Measures

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

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