Fabrication and characterization of polymer-infiltrated glass ceramic-titania scaffold for bone substitution

Thomas, Ashley; Bera, J.

doi:10.1080/10667857.2019.1661142

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…In addition, titanium nitride (TiN) coating has been licensed by the FDA to be used in titanium alloy components for enhancing durability and corrosion resistance in surgical steel, orthodontics, hip prostheses, and cardiovascular biomaterials [ 69 ]. A titania/glass ceramic (TiGC) scaffold was fabricated and coated with alginate, gelatin, and chitosan to enhance strength and durability [ 70 ]. In another strategy to improve the bioactivity of titania scaffolds, alkaline phosphatase (ALP) was functionalized onto 3D TiO 2 scaffolds based on a simple dip-coating method.…”

Section: Reviewmentioning

confidence: 99%

Engineered titania nanomaterials in advanced clinical applications

Sahare¹,

Alvarez²,

Yanez³

et al. 2022

Beilstein J. Nanotechnol.

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Significant advancement in the field of nanotechnology has raised the possibility of applying potent engineered biocompatible nanomaterials within biological systems for theranostic purposes. Titanium dioxide (titanium(IV) oxide/titania/TiO2) has garnered considerable attention as one of the most extensively studied metal oxides in clinical applications. Owing to the unique properties of titania, such as photocatalytic activity, excellent biocompatibility, corrosion resistance, and low toxicity, titania nanomaterials have revolutionized therapeutic approaches. Additionally, titania provides an exceptional choice for developing innovative medical devices and the integration of functional moieties that can modulate the biological responses. Thus, the current review aims to present a comprehensive and up-to-date overview of TiO2-based nanotherapeutics and the corresponding future challenges.

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Section: Reviewmentioning

confidence: 99%

Engineered titania nanomaterials in advanced clinical applications

Sahare¹,

Alvarez²,

Yanez³

et al. 2022

Beilstein J. Nanotechnol.

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“…Highly porous composite scaffolds were prepared by different methods, e.g., solvent casting-particulate leaching ( Baek et al, 2012 ; Wu et al, 2017 ), 3D printing ( Huang et al, 2018 ), sponge replication followed by dip coating ( Thomas and Bera, 2020 ), phase inversion technique ( Podporska-Carroll et al, 2014 ), electrospinning ( Suslu et al, 2014 ), and a combination of electrospinning and electrospraying ( Ramier et al, 2014 ). Among these listed techniques electrospinning is especially interesting as it allows for the production in single-step hybrid meshes from a mixed polymer solution and ceramic particles.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Karbowniczek

Kaniuk

Berniak

et al. 2021

Front. Bioeng. Biotechnol.

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Hybrid materials combining organic and inorganic compounds used as scaffolds are highly beneficial in bone regeneration. In this study, we successfully produced by blend electrospinning poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) scaffolds enriched with hydroxyapatite (HA) particles to biomimic bone tissue for improved and faster regeneration processes. The morphology, fiber diameters, and composition of the scaffolds were investigated by scanning electron microscopy (SEM) techniques followed by focused ion beam (FIB) sectioning to verify HA particles integration with PHBV fibers. In vitro cell culture was performed for 7 days and followed with the cell proliferation test (CellTiter-Blue® Assay). Additionally, cell integration with the scaffold was visualized by confocal and SEM imaging. We developed a simple way of obtaining hybrid scaffolds by electrospinning PHBV solution with HA particles without any post-processing. The PHBV + HA scaffold enhanced cell proliferation and filopodia formation responsible for cell anchoring within the created 3D environment. The obtained results show the great potential in the development of hybrid scaffolds stimulating bone tissue regeneration.

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