Fabrication and characterization of porous 3D whisker-covered calcium phosphate scaffolds

Ye, Xingjiang; Zhou, Changchun; Xiao, Zhu; Fan, Yujiang; Zhu, Xiangdong; Sun, Yong; Zhang, Xingdong

doi:10.1016/j.matlet.2014.04.142

Cited by 31 publications

(13 citation statements)

References 20 publications

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“…However, as tested in our pilot trails, these traditional methods merely provide the scaffold with good bioactivity but are not able to achieve functional n-HA release at sufficient concentration. Therefore, we developed a novel approach to synthesize a thick n-HA coating on the porous scaffold in situ based on the slurry foaming method and impregnation process, modified from our previous work ( 21 , 56 ). From the release experiments, the weight-changing records revealed that n-HA could be continuously released from the scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect

et al. 2019

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Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material and as an antitumor agent. Inhibition of tumor growth, prevention of metastasis, and enhancement of the survival rate of tumor-bearing rabbits treated with n-HA were demonstrated. Activated mitochondrial-dependent apoptosis in vivo was confirmed, and we observed that a stimulated immune response was involved in the n-HA–induced antitumor effect. A porous titanium scaffold loaded with n-HA was fabricated and implanted into a critical-sized segmental bone defect in a rabbit tumor model. The n-HA–releasing scaffold not only showed a prominent effect in suppressing tumor growth and osteolytic lesion but also promoted bone regeneration. These findings provide a rationale for using n-HA in tumor-associated bone segmental defects.

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Section: Discussionmentioning

confidence: 99%

Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect

et al. 2019

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“…Preparation of BCP scaffolds doped with Cu/Zn ions Firstly, calcium decient apatite powders co-doped with Cu/Zn ions were synthesized by a wet chemical precipitation method. 30 Briey, a mixed solution of Ca(NO 3 ) 2 $4H 2 O, Zn(NO 3 ) 2 $6H 2 O, Cu(NO 3 ) 2 $3H 2 O and sodium dodecyl sulfate (0.03 M) were prepared and added dropwise into (NH 4 ) 2 HPO 4 solution under stirring at room temperature with a (Ca + Zn + Cu)/P molar ratio of 1.55. The pH of the solution was adjusted to 8 by adding ammonia solution.…”

Section: Methodsmentioning

confidence: 99%

Fabrication of a Cu/Zn co-incorporated calcium phosphate scaffold-derived GDF-5 sustained release system with enhanced angiogenesis and osteogenesis properties

et al. 2018

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“…To address these challenges, the HA scaffolds with desirable micro/nano-structures need to be fabricated for regulating cell behavior. Thus, various techniques have been reported for the creation of surface coatings or modification of calcium phosphate scaffolds, such as precipitation, sol-gel, solid-state, hydrothermal and biomimetic methods [ 9 , 11 , 12 ]. Of these, the hydrothermal process provides quick production with relative technical simplicity and high product crystallinity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Micro/Nano-Structure Copper-Substituted Hydroxyapatite Scaffolds with Improved Angiogenesis Capacity for Bone Regeneration

et al. 2018

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The surface microstructures of calcium phosphate ceramics play an essential role in determining bone regeneration. However, it is difficult to produce micro/nano-structures on the surface of the porous hydroxyapatite (HA) scaffolds. In this study, we successfully developed and fabricated various micro/nano-structured surfaces on the HA scaffolds in copper ion (Cu2+)-containing solutions under hydrothermal conditions. The micro/nano-structures on the surface of the HA scaffolds were controlled by modulating the Cu2+ concentrations during the hydrothermal process. With an increase in the Cu2+ concentration, the surface morphology of the HA scaffolds changed significantly from sphere-like to flower-like, before becoming nano-structures. These findings indicated that the Cu2+ concentration affects the morphologies of calcium phosphate coatings that grow on the HA scaffolds. In vitro endothelial cell (EC) cultures showed that the cell proliferation was significantly enhanced when cultured on the flower-like morphology compared with other morphologies. Furthermore, an in vivo test in New Zealand rabbits demonstrated that the HA scaffold with the flower-like surface resulted in more angiogenesis compared with the control scaffold. This copper-assisted hydrothermal deposition process provides a simple and controllable route for engineering a micro/nano-structured surface on the HA scaffolds, which has benefits in terms of angiogenesis and bone regeneration.

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Fabrication and characterization of porous 3D whisker-covered calcium phosphate scaffolds

Cited by 31 publications

References 20 publications

Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect

Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect

Fabrication of a Cu/Zn co-incorporated calcium phosphate scaffold-derived GDF-5 sustained release system with enhanced angiogenesis and osteogenesis properties

Preparation of Micro/Nano-Structure Copper-Substituted Hydroxyapatite Scaffolds with Improved Angiogenesis Capacity for Bone Regeneration

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