Fabrication and characterization of the H/J-type aggregates astaxanthin/bovine serum albumin/chitosan nanoparticles

Zhao, Yingyuan; Liu, Junxia; Zhang, Shengmeng; Wang, Zhaoxuan; Jia, Huihui; Oda, Hiroaki; Li, Ruifang

doi:10.1016/j.ijbiomac.2022.11.006

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…The freshly prepared ABC-NPs with J-type astaxanthin aggregates nanosuspensionwas pink-purple and a clear Tyndal pathway could be observed by illumination with a red laser beam. The above phenomenon indicated that the ABC-NPs was well dispersed and homogeneous [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…After preparing the above three solutions, store them in a refrigerator at 4 °C. The ABC-NPs were prepared following the procedure described by our research team with some optimization [ 24 ]. Under light-proof conditions, we slowly poured 50 mL of astaxanthin solution with a concentration of 0.03 mg/mL into 50 mL of chitosan solution with a concentration of 0.1 mg/mL at an addition rate of 43 mL/min for about 70 s, followed by magnetic stirring for 20 min.…”

Section: Methodsmentioning

confidence: 99%

“…Freshly prepared 1 mL ABC-NPs was added to the cuvette and placed in the sample chamber with an equilibration time of 120 s. The dispersant medium was water with a dispersant RI of 1.330 and a material RI of 1.45. Each sample was measured for three times and analyzed the average value [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

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Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension

et al. 2023

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Astaxanthin is a carotenoid with excellent antioxidant activity. However, this small lipid-soluble molecule is insoluble in water and has low stability. Although this situation can be improved when astaxanthin is prepared as a nanosuspension, the aqueous form is still not as convenient and safe as the dry powder form for storage, transport, and use. The lyophilization process provides better protection for thermosensitive materials, but this leads to collapse and agglomeration between nanoparticles. To improve this situation, appropriate lyophilization protectants are needed to offer support between the nanoparticles, such as sugars, amino acids, and hydroxy alcohols. The purpose of this work is to screen lyophilization protectants by single-factor experiments and response surface optimization experiments and then explore the optimal ratio of compound lyophilization protectants, and finally, make excellent astaxanthin/BSA/chitosan nanosuspension (ABC-NPs) lyophilized powder. The work shows that the optimal ratio of the compounding lyophilization protectant is 0.46% oligomeric mannose, 0.44% maltose, and 0.05% sorbitol (w/v). The ABC-NPs lyophilized powder prepared under the above conditions had a re-soluble particle size of 472 nm, with a ratio of 1.32 to the particle size of the sample before lyophilization. The lyophilized powder was all in the form of a pink layer. The sample was fluffy and dissolved entirely within 10 s by shaking with water. Consequently, it is expected to solve the problem of inconvenient storage and transportation of aqueous drugs and to expand the application of nanomedicine powders and tablets.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension

et al. 2023

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“…In recent years, emerging nanotechnology has provided a new platform to solve the drug solubility challenge, with polymer micelles being an important platform. In particular, promising drug delivery systems are new research hotspot, with most of the latest studies focusing on the development of drug delivery 12,26,27 . In addition, polymer micelles with stability, biocompatibility and solubilizing properties have attracted great attention for oral administration.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, promising drug delivery systems are new research hotspot, with most of the latest studies focusing on the development of drug delivery. 12,26,27 In addition, polymer micelles with stability, biocompatibility and solubilizing properties have attracted great attention for oral administration. The present study aims to explore HPCD and amphiphilic polymer materials as carriers to enhance the stability and water solubility of astaxanthin, as well as prepare an astaxanthin-containing multimicellar system.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

et al. 2023

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BACKGROUND Astaxanthin is a type of food‐derived active ingredient with antioxidant, antidiabetic and non‐toxicity functions, but its poor solubility and low bioavailability hinder further application in food industry. In the present study, through inclusion technologies, micellar solubilization and electrospray techniques, we prepared astaxanthin nanoparticles before optimizing the formulation to regulate the physical and chemical properties of micelles. We accomplished the preparation of astaxanthin nanoparticle delivery system based on single needle electrospray technology through use of 2‐hydroxypropyl‐β‐cyclodextrin and Soluplus® to improveme the release behavior of the nanocarrier. RESULTS Through this experiment, we successfully prepared astaxanthin nanoparticles with a particle size of approximately 80 nm, which was further verified with scanning electron microscopy and transmission electron microscopy. Furthermore, the encapsulation of astaxanthin molecules into the carrier nanoparticles was verified via the results of attenuated total reflectance intensity and X‐ray powder diffraction techniques. The in vitro release behavior of astaxanthin nanoparticles was different in media that contained 0.5% Tween 80 (pH 1.2, 4.5 and 6.8) buffer solution and distilled water. Also, we carried out a pharmacokinetic study of astaxanthin nanoparticles, in which it was observed that astaxanthin nanoparticle showed an effect of immediate release and significant improved bioavailability. CONCLUSION 2‐hydroxypropyl‐β‐cyclodextrin and Soluplus® were used in the present study as a hydrophilic nanocarrier that could provide a simple way of encapsulating natural function food with repsect to improving the solubility and bioavailability of poorly water‐soluble ingredients. © 2023 Society of Chemical Industry.

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Advance toward function, production, and delivery of natural astaxanthin: A promising candidate for food ingredients with future perspectives

Zhang,

Liu,

Han

et al. 2025

Food Chemistry

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Fabrication and characterization of the H/J-type aggregates astaxanthin/bovine serum albumin/chitosan nanoparticles

Cited by 6 publications

References 45 publications

Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension

Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

Advance toward function, production, and delivery of natural astaxanthin: A promising candidate for food ingredients with future perspectives

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