Fabrication and characterization of three-dimensional polycaprolactone/sodium alginate and egg whites and eggshells hybrid scaffold in bone tissue engineering

Abstract

The aim of this study was to fabricate three-dimensional bone scaffolds using polycaprolactone and egg shell powder. The scaffolds were coated with sodium alginate/egg white. SEM was used to investigate egg shell particles on the surface of each string of scaffolds. The presence of calcium carbonate in the scaffold structure was confirmed by microstructural analyses employing XRD. Egg shell-related functional groups were discovered using FTIR investigations. Bone cells were used to conduct biocompatibility tests on scaffolds (MG-63). Finally, scaffolds with the highest proportion of egg whites and eggshells have the best cell survival rate. It may be concluded that the PCL/7% Esh/15% Ew scaffold is a good option for application in bone tissue engineering.