Fabrication and characterization of zein-sodium alginate complex nanoparticles as an effective naringenin delivery system: Physicochemical stability, solubility, antioxidant activity

Wu, Tianlong; Han, Wen; Han, Yuting; Ma, Lijie; Li, Mo; Sun, Yichi; Liu, Bingyang; Tian, Baocheng; Fu, Qiang

doi:10.1016/j.molliq.2023.122569

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…66 The decline suggested that the particle surface becomes increasingly saturated with ions, and this saturation eventually destroys the shielding effect and restores the pristine state. 66 This electrostatic screening effect results in a decrease in the surface charge of nanoparticles, 67 while the zeta-potential is on an upward trend, as shown in Fig. 4(c).…”

Section: Effect Of Ph and Salt Ions On The Stability Of Nanoparticlesmentioning

confidence: 93%

“…69 Furthermore, the larger surface area of nanoparticles and the elevated remaining phytol under various conditions, as discussed in the preceding sections, provided more opportunities for interaction with hydroxyl radicals and ABTS free radicals to enhance their scavenging efficacy. 67,70 In vitro cytotoxicity As presented in Fig. 5(c), inconspicuous cytotoxicity was observed in the range of 50-100 μg mL −1 , with over 70% of cells surviving after 24 h of incubation.…”

Section: Abts Free Radical Scavenging Activity and Hydroxyl Radical S...mentioning

confidence: 95%

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Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Chen,

Wang,

et al. 2024

J Sci Food Agric

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BACKGROUNDTo improve phytol bioavailability, a novel method of magnetic stirring and high‐pressure homogenization (HPH) combination was used to prepare zein/fucoidan‐coated phytol nanoliposomes (P‐NL‐ZF). The characterization, the simulated in vitro digestion, and the antioxidant activity of these phytol nanoliposomes from the different processes have been studied.RESULTSBased on the results of dynamic light scattering (DLS) and gas chromatography–mass spectrometer (GC–MS) analysis, P‐NL‐ZF prepared through the combination of magnetic stirring and HPH exhibited superior encapsulation efficiency at 76.19% and demonstrated exceptional physicochemical stability under a series of conditions, including storage, pH, and ionic in comparison to single method. It was further confirmed that P‐NL‐ZF by magnetic stirring and HPH displayed a uniform distribution and regular shape through transmission electron microscopy (TEM). Fourier‐transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) analysis showed that electrostatic interactions and hydrogen bonding were the primary driving forces for the formation of composite nanoliposomes. Additionally, an in vitro digestion study revealed that multilayer composite nanoliposomes displayed significant and favorable slow‐release properties (58.21%) under gastrointestinal conditions compared with traditional nanoliposomes (82.36%) and free phytol (89.73%). The assessments of chemical and cell‐based antioxidant activities demonstrated that the coating of zein/fucoidan on phytol nanoliposomes resulted in enhanced effectiveness in scavenging activity of ABTS free radical and hydroxyl radical and mitigating oxidative damage to HepG2 cells.CONCLUSIONBased on our studies, the promising delivery carrier of zein/fucoidan‐coated nanoliposomes is contributed to the encapsulation of hydrophobic natural products and enhancement of their biological activity. © 2024 Society of Chemical Industry.

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Section: Effect Of Ph and Salt Ions On The Stability Of Nanoparticlesmentioning

confidence: 93%

Section: Abts Free Radical Scavenging Activity and Hydroxyl Radical S...mentioning

confidence: 95%

Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Chen,

Wang,

et al. 2024

J Sci Food Agric

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“…Coating zein nanoparticles with biopolymers improves their stability and the presence of different functional groups facilitates the interaction between nanoparticles and bioactive molecules, thus increasing encapsulation (Yuan et al 2022 ). Among the biopolymers with the ability to improve the stability of zein nanoparticles, two polymers that occur naturally in the marine environment stand out: alginate and chitosan (Carrasco-Sandoval et al 2021 ; Jiang et al 2021 ; Khan et al 2019 ; Loureiro et al 2022 ; Pauluk et al 2019 ; Wu et al 2023 ). These polymers are low in toxicity, biodegradable, and biocompatible (Abdel-Ghany and Salem 2020 ; Lee and Mooney, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antioxidant activity of encapsulated tea polyphenols in chitosan/alginate-coated zein nanoparticles: a possible supplement against fish pathogens in aquaculture

Fabrikov,

Varga,

García

et al. 2024

Environ Sci Pollut Res

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Regulation of antibiotic use in aquaculture calls for the emergence of more sustainable alternative treatments. Tea polyphenols (GTE), particularly epigallocatechin gallate (EGCG), have various biological activities. However, tea polyphenols are susceptible to degradation. In this work, EGCG and GTE were encapsulated in zein nanoparticles (ZNP) stabilized with alginate (ALG) and chitosan (CS) to reduce the degradation effect. ALG-coated ZNP and ALG/CS-coated ZNP encapsulating EGCG or GTE were obtained with a hydrodynamic size of less than 300 nm, an absolute ζ-potential value >30 mV, and an encapsulation efficiency greater than 75%. The antioxidant capacity of the encapsulated substances, although lower than that of the free ones, maintained high levels. On the other hand, the evaluation of antimicrobial activity showed greater efficiency in terms of growth inhibition for ALG/CS-ZNP formulations, with average overall values of around 60%, reaching an inhibition of more than 90% for Photobacterium damselae. These results support encapsulation as a good strategy for tea polyphenols, as it allows maintaining significant levels of antioxidant activity and increasing the potential for antimicrobial activity, in addition to increasing protection against sources of degradation.

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Impact of calcium‐reinforcement on stability, bioavailability, and bioactivity of quercetin‐loaded zein/alginate‐pectin nanoparticles

Li,

Zhu,

Zhou

et al. 2024

J Sci Food Agric

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BACKGROUNDCationic calcium ions can crosslink anionic alginate and pectin molecules. It was hypothesized that calcium crosslinking would improve the stability and functionality of biopolymer nanoparticles consisting of zein cores coated by alginate‐pectin shells. The effects of calcium ion addition on the structural, physicochemical, and gastrointestinal properties of quercetin‐loaded zein/alginate‐pectin nanoparticles were therefore investigated.RESULTSThe nanoparticles remained stable to aggregation at calcium ion concentrations of 9 mmol/L or less but aggregated and sedimented at higher concentrations. Calcium ion reinforcement increased the particle dispersion stability even at NaCl concentrations up to 1.4 molL‐1. The presence of the calcium ions also reduced quercetin release during the early stages of simulated gastrointestinal digestion but increased its release during the later stages. The relatively high release (56.1%) of quercetin from the calcium‐reinforced nanoparticles after digestion resulted in higher intracellular antioxidant activities. The pharmacokinetics of the encapsulated quercetin was measured after its oral administration to rats. The maximal concentration (Cmax) of quercetin in rat plasma for calcium‐reinforced nanoparticles was 6.1% higher than non‐reinforced nanoparticles; the half‐life (t1/2) increased by 17.5%, and the mean retention time (MRT) was 10.0% higher (P < 0.05).CONCLUSIONThese results suggest that calcium ion addition improved the performance and bioavailability of nutraceutical‐loaded biopolymer nanoparticles. This might find application in the food and beverage industry. © 2024 Society of Chemical Industry.

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Fabrication and characterization of zein-sodium alginate complex nanoparticles as an effective naringenin delivery system: Physicochemical stability, solubility, antioxidant activity

Cited by 11 publications

References 41 publications

Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Antimicrobial and antioxidant activity of encapsulated tea polyphenols in chitosan/alginate-coated zein nanoparticles: a possible supplement against fish pathogens in aquaculture

Impact of calcium‐reinforcement on stability, bioavailability, and bioactivity of quercetin‐loaded zein/alginate‐pectin nanoparticles

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