Fabrication and characterization of ZnO modified bioactive glass nanoparticles

El-Kady, Abeer M.; Ali, Ashraf F.

doi:10.1016/j.ceramint.2011.07.069

Cited by 84 publications

(54 citation statements)

References 23 publications

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“…ZnOcontaining BGN have been produced using one-step alkalimediated sol-gel method with the assistance of ultrasonic dispersion and mechanical agitation. 17,18 However, the dispersity and uniformity of the synthesized nanoparticles still require improvement. The challenge to produce highly dispersed and uniform BGN in the conventional one-step sol-gel method is that the addition of salt precursors may destabilize the nanoparticles by changing their surface charge.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, the synthesis of highly dispersed BGN containing multifold metallic ions is still challenging through conventional sol-gel based methods, as metallic precursors can deteriorate the stability of nanoparticles during synthesis and consequently cause aggregation and irregularity in the resulting BGN. 15,16 Zn-containing BGN showing high bioactivity have been synthesized via a quick alkali-mediated sol-gel method, 17,18 but the dispersion and uniformity of the synthesized BGN should be improved when they are considered for use in nanocomposites. As an alternative, metal or metal oxide nanoparticles can be coated on nanoparticles to introduce metallic ions, while at the same time the high dispersion of the nanoparticles is maintained.…”

Section: Introductionmentioning

confidence: 99%

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ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

et al. 2016

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a Zinc (Zn)-containing materials have osteogenic and antibacterial activities while bioactive glass nanoparticles (BGN) show bone-bonding ability, as well as osteoconductive and osteoinductive properties. Zn-containing BGN are therefore considered to be promising materials for various biomedical applications, particularly in bone regeneration. In this study, we report a convenient method to prepare Zn-containing BGN by coating ZnO quantum dots (QDs) on BGN via electrostatic interactions. The synthesized ZnO-BGN nanocomposite particles are spherical and highly dispersed, and exhibit a unique fluorescence behavior under UV excitation, emitting three wavelengths in the violet, blue and green range.ZnO-BGN showed apatite-forming ability upon immersion in simulated body fluid, but their apatite formation was delayed compared to BGN. Interestingly, ZnO-BGN showed a rapid release of Zn ions at pH 4 but a far slower release at pH 7.4. ZnO-BGN also exhibited antibacterial effects on both Gram-positive and Gram-negative bacteria at the concentrations of 1, 0.1, and 0.01 mg mL , but ZnO-BGN inhibited the relative proliferation of hMSC compared to BGN and the control according to the MTT assay. Notably ZnO-BGN improved the osteogenic differentiation of hMSC as indicated by the determination of the alkaline phosphatase activity. In conclusion, coating quantum dots on BGN is a promising strategy to produce Zn-containing BGN. The synthesized ZnO-BGN are potential materials for bone regeneration, considering their apatite-forming ability, unique ion-release behavior, effective antibacterial activity, non-cytotoxicity, and osteogenic potential.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

et al. 2016

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“…A band in the range 1000-880 cm -1 attributed to stretching vibration of Si-O-NBO (non-bridging oxygen) was observed in both the non-calcined MBGs. This band is the evidence of presence of Si-O-Ca ?2 [18,19]. This band is either absent or eclipsed by P-O stretching shoulder (964 cm -1 ) in the heat-treated MBGs.…”

Section: Thermal Behaviour Of Mesoporous Bioactive Glassesmentioning

confidence: 89%

A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass

et al. 2014

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A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 -26CaO-10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700°C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2 g -1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2 g -1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3 g -1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3 g -1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased DT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high DT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP.

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“…According to previous studies, certain ions play a role as nucleating agents in bioactive glasses (49). Therefore, it seems that the number of fabricated nuclei increases preferably instead of an increase in their sizes, resulting in a decrease in grain size in the presence of CuO and ZnO.…”

Section: Discussionmentioning

confidence: 99%

“…This influences bioactivity, the dissolution rate, and effective ion release in osteogenesis during the submersion of the samples in SBF in vitro. It was found that some ions cause nucleation in bioactive glasses (49). Therefore, it seems that in the presence of CuO, the number of nuclei formed is determined by their growth, which results in a decrease in particle dimensions.…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

Alijanian¹,

Talebian²,

Doudi³

2016

Avicenna J Med Biochem

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Background: In recent years, bioactive bioceramics such as bioglass and hydroxyapatite (HA) have been introduced as a remarkable development in the field of medicine due to their bio-adaptability, non-toxicity, and persistence, in vivo. They have many potential applications in the repair of bone defects and hence they have attracted significant interest from scholars. Objectives: The aim of this study was to synthesize inorganic matrix CuO-based bioglasses and evaluate their antibacterial activity against aerobic bacterial infections in bone implants. Methods: Nano-composite samples of silica-based bioactive glass, 60S BG with nano-powder CuO, were synthesized using the sol-gel method and then assessed with regard to their antibacterial properties against Staphylococcus aureus using well diffusion agar. The samples included BG58S (58%SiO2, 36%CaO, 6%P2O5), BG/10CuO (58%SiO2, 26%CaO, 6%P2O5, 10%CuO), and BG/20CuO (48%SiO2, 26%CaO, 6%P2O5, 20%CuO). To evaluate their bioactivity, the prepared samples of BG/20CuO, BG/10CuO, and BG58S were immersed in simulated body fluids (SBF). The surface morphology and structure of the samples before and after immersion in the SBF were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively. Then, the BG/20CuO and BG/10CuO samples were loaded in clindamycin, an antibiotic widely used in the treatment of osteomyelitis, and their release profiles were studied in phosphate buffer solution. Results: It was observed that the growth inhibition zone increased through clindamycin release due to the increasing CuO percentage in the nanocomposite of bioactive glass. The bioactivity of the nanocomposite/bioglass with CuO was superior to that of bioglass alone. In this study, the BG/20CuO sample showed a sustained release of clindamycin, which is sufficient for a drug delivery system. Conclusions: Increasing the Cu nanoparticles in bioactive glass samples leads to the release of Cu 2+ , which has a positive effect on the antibacterial mechanism, as well as decreasing the cultured Staphylococcus colonies found on the bioglasses. Therefore, it seems that the nanocomposite/bioglass of CuO is a promising option for aerobic bacterial inhibitor systems in common bone implant infections.

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Fabrication and characterization of ZnO modified bioactive glass nanoparticles

Cited by 84 publications

References 23 publications

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

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