Fabrication and evaluation of a chitin whisker/poly(<scp>l</scp>-lactide) composite scaffold by the direct trisolvent-ink writing method for bone tissue engineering

Liu, Kun; Zhu, Ling; Tang, Shengyue; Wen, Wei; Lu, Lu; Liu, Mingxian; Zhou, Changren; Luo, Binghong

doi:10.1039/d0nr04204h

Cited by 33 publications

(26 citation statements)

References 41 publications

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“…Moreover, the preparation of synthetic scaffolds is time-consuming, as, for example, in the construction of two kinds of porous ceramics, a novel sintered porous hydroxyapatite, and a porous β-tricalcium phosphate (β-TCP), as well as a collagen-phosphosphoryn sponge as scaffolds for bone cell culture, which took a relatively time-consuming process to prepare [ 50 ]. On the other hand, the osteogenic activity of synthetic polymers might not meet the needs of bone tissue repair, such as in the case of poly (L-lactide) (PLLA)-based porous scaffolds, which have been extensively fabricated through 3D printing; their osteogenic activity still does not meet the needs of bone tissue repair [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Crossing Phylums: Butterfly Wing as a Natural Perfusable Three-Dimensional (3D) Bioconstruct for Bone Tissue Engineering

Mostofi

Niroomand

et al. 2022

JFB

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Despite the advent of promising technologies in tissue engineering, finding a biomimetic 3D bio-construct capable of enhancing cell attachment, maintenance, and function is still a challenge in producing tailorable scaffolds for bone regeneration. Here, osteostimulatory effects of the butterfly wings as a naturally porous and non-toxic chitinous scaffold on mesenchymal stromal cells are assessed. The topographical characterization of the butterfly wings implied their ability to mimic bone tissue microenvironment, whereas their regenerative potential was validated after a 14-day cell culture. In vivo analysis showed that the scaffold induced no major inflammatory response in Wistar rats. Topographical features of the bioconstruct upregulated the osteogenic genes, including COL1A1, ALP, BGLAP, SPP1, SP7, and AML3 in differentiated cells compared to the cells cultured in the culture plate. However, butterfly wings were shown to provide a biomimetic microstructure and proper bone regenerative capacity through a unique combination of various structural and material properties. Therefore, this novel platform can be confidently recommended for bone tissue engineering applications.

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Section: Discussionmentioning

confidence: 99%

Crossing Phylums: Butterfly Wing as a Natural Perfusable Three-Dimensional (3D) Bioconstruct for Bone Tissue Engineering

Mostofi

Niroomand

et al. 2022

JFB

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“…2A, the characteristic functional groups of chitosan were obtained by total reflection infrared spectrometry. Because the number of amino groups in the chitosan polysaccharide chains began to increase during chitin deacetylation [14,15], more amino functional groups were detected on chitosan. The amine vibrations resulted in sharp characteristic peaks at 3200-3500 cm −1 [16,17].…”

Section: Analyses Of the Properties Of Gelatin Chitosan And Inksmentioning

confidence: 99%

Reproducing ancient Chinese ink depending on gelatin/chitosan and modern experimental methodology

Liu

2022

Herit Sci

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Chinese ink has very special significance for presentation of artistic effects and preservation of works of art; however, wasted nonrenewable resources, potential toxicity, and complex and inefficient production technologies have limited the development of inks for traditional Chinese culture. Herein, environmentally friendly, practical and antibacterial Chinese ink was prepared by facile heating-stirring of gelatin and the natural polysaccharide chitosan. The internal composition, viscosity, morphology, particle size and antibacterial properties of the ink were characterized by Fourier transform-infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy and bacteriostatic zone tests. The results showed that commercial ink (CM) spread easily on Xuan paper and led to imperfect artwork, while the chitosan and gelatin ink (CG) showed good adhesion and stability on Xuan paper. Based on this study, we believe that the good performance of CG ink should be attributed to restrictions arising from its internal chitosan and gelatin network, which restrict diffusion. Finally, the author used CG ink to display traditional Chinese calligraphy and landscape painting and believes that it has significant application prospects and will be used in large-scale production.

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“…[7] Due to the geometrical limits the whiskers began to agglomerate as the content increased, and affected the mechanical properties of the composites. [22] Owing to the chain entanglement of the PLLA matrix and PLLA chains F I G U R E 2 FESEM morphologies of the fracture surfaces of the pure PLLA, CWs/PLLA, and g-CWs/PLLA composites (when the whiskers content was 2.5, 5, and 10 wt%) which were grafted on the surface of the g-CWs, the g-CWs had excellent interface compatibilities with PLLA matrix and the dispersion in the matrix was more uniform, thereby the tensile, flexural, and impact performances of the g-CWs/PLLA composites was better than that of the CWs/PLLA composites with the same whiskers content. [23][24][25]…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Mechanical and nonisothermal cold crystallization behaviors of injection molded surface‐modified chitin whiskers/poly(l‐lactide) composites

Wen

Luo

et al. 2021

Polymer Composites

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To improve the mechanical, crystallization performances of poly(L-lactide) (PLLA), pristine and surface grafted chitin whiskers (CWs and g-CWs) were introduced to PLLA via melt blending. Attributed to the good interfacial compatibility between the g-CWs and PLLA matrix, the tensile, flexural, and impact performances of the g-CWs/PLLA composites were better than that of the CWs/PLLA composites with the same whiskers content. The whiskers acted as nucleating agents to promote the crystallization of the PLLA matrix on the one hand, and acted as obstacles to restrict the crystals growth on the other hand. The nonisothermal cold crystallization kinetics revealed that the crystallization rate and crystallinity of the PLLA matrix were improved by the addition of the whiskers, but the promotion effect of g-CWs was more obvious than CWs.

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Fabrication and evaluation of a chitin whisker/poly(l-lactide) composite scaffold by the direct trisolvent-ink writing method for bone tissue engineering

Abstract: Although poly(L-lactide) (PLLA) based porous scaffolds have been widely fabricated through 3D printing, their poor mechanical properties and osteogenic activity still do not meet the needs of bone tissue repair....

Cited by 33 publications

References 41 publications

Crossing Phylums: Butterfly Wing as a Natural Perfusable Three-Dimensional (3D) Bioconstruct for Bone Tissue Engineering

Crossing Phylums: Butterfly Wing as a Natural Perfusable Three-Dimensional (3D) Bioconstruct for Bone Tissue Engineering

Reproducing ancient Chinese ink depending on gelatin/chitosan and modern experimental methodology

Mechanical and nonisothermal cold crystallization behaviors of injection molded surface‐modified chitin whiskers/poly(l‐lactide) composites

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