Fabrication and evaluation of [Co(phen)2L]3+-modified DNA-MWCNT and SDS-MWCNT electrodes for electrochemical detection of 6-mercaptopurine

Zhou, Peina; He, Lei-Qing; Gan, Gui-Lian; Ni, Shenyan; Li, Hong; Li, Weishan

doi:10.1016/j.jelechem.2011.11.026

Cited by 28 publications

(4 citation statements)

References 39 publications

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“…[131] Similarly, determinations of 6-thioguanine, [132] nelarabine [133] (both purine analogs), 5-fluorouracil [68] (pyrimidine analog) were carried out only on traditional Hg dropping electrodes. However, the more advanced approach based on polypyridyl cobalt complexes used as modifiers [134,135] was utilized for 6-mercaptopurine (purine analog) detection. Also, one sensing protocol utilized the reduction signal of the 6-mercaptopurine-Cu 2þ complex, which was formed on a hanging copper amalgam drop electrode.…”

Section: Aunpsmentioning

confidence: 99%

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Brycht

Półtorak

Baluchová

et al. 2022

Critical Reviews in Analytical Chemistry

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Cancer is most frequently treated with antineoplastic agents (ANAs) that are hazardous to patients undergoing chemotherapy and the healthcare workers who handle ANAs in the course of their duties. All aspects related to hazardous oncological drugs illustrate that the monitoring of ANAs is essential to minimize the risks associated with these drugs. Among all analytical techniques used to test ANAs, electrochemistry holds an important position. This review, for the first time, comprehensively describes the progress done in electrochemistry of ANAs by means of a variety of bare or modified (bio)sensors over the last four decades (in the period of 1982-2021). Attention is paid not only to the development of electrochemical sensing protocols of ANAs in various biological, environmental, and pharmaceutical matrices but also to achievements of electrochemical techniques in the examination of the interactions of ANAs with deoxyribonucleic acid (DNA), carcinogenic cells, biomimetic membranes, peptides, and enzymes. Other aspects, including the enantiopurity studies, differentiation between single-stranded and double-stranded DNA without using any label or tag, studies on ANAs degradation, and their pharmacokinetics, by means of electrochemical techniques are also commented. Finally, concluding remarks that underline the existence of a significant niche for the basic electrochemical research that should be filled in the future are presented.

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Section: Aunpsmentioning

confidence: 99%

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Brycht

Półtorak

Baluchová

et al. 2022

Critical Reviews in Analytical Chemistry

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“…The non-covalent interactions of the tris-(1,10-phenanthroline)-Co(III) complex with DNA, demonstrated through cyclic voltammetry, has motived different research groups to develop new electrochemical biosensors based on DNA hybridization. Detection of human immunodeficiency virus (HIV), Escherichia coli, Hepatitis B virus and the chemotherapeutic agent for lymphoblastic leukemia, 6-Mercaptopurine, are some examples of these biosensors [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

The Role of the π Acceptor Character of Polypyridine Ligands on the Electrochemical Response of Co(II) Complexes and its Effect on the Homogenous Electron Transfer Rate Constant with the Enzyme Glucose Oxidase

Ramírez-Delgado¹,

Cruz-Ramírez²,

Hernández‐Ayala

et al. 2017

J. Mex. Chem. Soc.

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In this work the electrochemical behavior of Co(II) com-plexes with substituted bidentate and tridentate polypyridine ligands [CoL3](BF4)2 and [CoL´2](NO3)2 in 0.1M phosphate buffer pH 7.2 was studied. A reversible electrochemical process Co(II)Ln → Co(III) Ln +1eˉ was observed. A linear relationship between the redox poten-tial (E°) and the pKa of the non-coordinated ligand was found. It was demonstrated by DFT calculations the use of pKa value as a descriptor of the π acceptor character of a ligand. The electrochemical response in the presence of glucose oxidase (GOx) was also studied. It was pos-sible to establish a tendency between the homogeneous electron trans-fer rate constant (ks) and the redox potential (E°) for the compounds studied in this work and other examples taken from the literature.

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“…The use of quantum dots and nanoparticles has also gained popularity [9] . In the electrochemical detection mode one typically employs redox-active labels, such as methylene blue [ 10 , 11 ], ferrocen [ 12 , 13 ], ferricyanides [ 14 , 15 ] or Ru(bpy) 3 2+ [16] , Ru(phen) 3 2+ [17] , [Fe(CN) 6 ] 3−/4− [18] , [Ru(NH 3 ) 6 ] 3+ [19] , Co(phen) 3 3+ [20] complexes. There is also a tendency to use enzymes [21] catalytic activity of which allows for indirect determination of the analyte through determination of the respective products of enzymatic reaction.…”

Section: Introductionmentioning

confidence: 99%

Tetraphenylporphyrin as a protein label for triple detection analytical systems

Konopińska

Pietrzak

Mazur

et al. 2015

Heliyon

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Porphyrins and metalloporphyrins are promising new protein labels that can be detected using multiple techniques; improving the reliability of the analysis and broadening the range of the linear response. Here, we investigate the potential of 5,10,15,20-tetraphenyl-21H,23H-porphyrin (Tpp) as a hybrid protein label. The electrochemical and optical properties of porphyrin conjugated with bovine serum albumin (BSA), chicken egg albumin (CEA) and immunoglobulin G (IgG) were determined and optimal conditions for Tpp-protein conjugation established. Model conjugates of carboxylated Tpp with BSA and short peptides were characterized using differential pulse voltammetry, UV–Vis spectrophotometry and spectrofluorimetry. These results reveal that Tpp is a promising molecule to be used in a triple detection protein labelling system.

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Fabrication and evaluation of [Co(phen)2L]3+-modified DNA-MWCNT and SDS-MWCNT electrodes for electrochemical detection of 6-mercaptopurine

Cited by 28 publications

References 39 publications

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

The Role of the π Acceptor Character of Polypyridine Ligands on the Electrochemical Response of Co(II) Complexes and its Effect on the Homogenous Electron Transfer Rate Constant with the Enzyme Glucose Oxidase

Tetraphenylporphyrin as a protein label for triple detection analytical systems

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