Fabrication and evaluation of gelatin-PVA-co-poly(2-acrylamido-2-methylpropane sulfonic acid)-based hydrogels for extended-release of sitagliptin and metformin by employing response surface methodology

Tabassum, Maria; Pervaiz, Fahad; Shoukat, Hina

doi:10.1007/s11696-022-02155-7

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…Porosity increases as a result of the high viscosity of the reaction mixture which generates interconnected channels. As EGDMA concentration increased (from 0.5 to 1.5 w / w %), pores and pore sizes were reduced due to the formation of tight junctions and the creation of crosslinked bulk densities that affect the flexibility of the network [ 42 ]. The porosity of hydrogel was increased with the sodium alginate concentration was increased, which is consistent with previous studies [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

Naeem

Zhu

et al. 2022

Molecules

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Traditional wound dressings often cannot treat wounds caused by bacterial infections or other wound types that are insensitive to these wound treatments. Therefore, a biodegradable, bioactive hydrogel wound dressing could be an effective alternative option. The purpose of this study was to develop a hydrogel membrane comprised of sodium alginate, polyvinyl alcohol, acrylic acid, and gallic acid for treating skin wounds. The newly developed membranes were analyzed using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), sol-gel fraction, porosity, mechanical strength, swelling, drug release and data modelling, polymeric network parameters, biodegradation, and antioxidation (DPPH and ABTS) and antimicrobial activity against Gram-positive and negative bacteria. The results revealed that hydrogel membranes were crosslinked successfully and had excellent thermal stability, high drug loading, greater mechanical strength, and exhibited excellent biodegradation. Additionally, the swelling ability and the porosity of the surface facilitated a controlled release of the encapsulated drug (gallic acid), with 70.34% release observed at pH 1.2, 70.10% at pH 5.5 (normal skin pH), and 86.24% at pH 7.4 (wounds pH) in 48 h. The gallic acid-loaded hydrogel membranes showed a greater area of inhibition against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli bacteria as well as demonstrated excellent antioxidant properties. Based on Franz cell analyses, the permeation flux of the drug from optimized formulations through mice skin was 92 (pH 5.5) and 110 (pH 7.4) μg/cm2·h−1. Moreover, hydrogel membranes retained significant amounts of drug in the skin for 24 h, such as 2371 (pH 5.5) and 3300 µg/cm2 (pH 7.4). Acute dermal irritation tests in rats showed that hydrogel membranes were nonirritating. Hydrogel membranes containing gallic acid could be an effective option for improving wound healing and could result in faster wound healing.

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Section: Resultsmentioning

confidence: 99%

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

Naeem

Zhu

et al. 2022

Molecules

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“…Porosity percentages ranged from 43.60% to 88.90% under different reagent ratios. The diameter of the pores decreases as the concentration of EGDMA increases due to the development of tight junctions and the increased cross-linking density, thereby reducing the network's flexibility [55]. A higher concentration of AMPS improves porosity because the sulfonate groups are able to generate stronger electrostatic forces.…”

Section: Porosity Evaluationmentioning

confidence: 99%

Ellagic Acid Inclusion Complex-Loaded Hydrogels as an Efficient Controlled Release System: Design, Fabrication and In Vitro Evaluation

Naeem

Liu

et al. 2023

JFB

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Oxidants play a crucial role in the development of oxidative stress, which is linked to disease progression. Ellagic acid is an effective antioxidant with applications in the treatment and prevention of several diseases, since it neutralizes free radicals and reduces oxidative stress. However, it has limited application due to its poor solubility and oral bioavailability. Since ellagic acid is hydrophobic, it is difficult to load it directly into hydrogels for controlled release applications. Therefore, the purpose of this study was to first prepare inclusion complexes of ellagic acid (EA) with hydroxypropyl-β-cyclodextrin and then load them into carbopol-934-grafted-2-acrylamido-2-methyl-1-propane sulfonic acid (CP-g-AMPS) hydrogels for orally controlled drug delivery. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) were used to validate ellagic acid inclusion complexes and hydrogels. There was slightly higher swelling and drug release at pH 1.2 (42.20% and 92.13%) than at pH 7.4 (31.61% and 77.28%), respectively. Hydrogels had high porosity (88.90%) and biodegradation (9.2% per week in phosphate-buffered saline). Hydrogels were tested for their antioxidant properties in vitro against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Additionally, the antibacterial activity of hydrogels was demonstrated against Gram-positive bacterial strains (Staphylococcus aureus and Escherichia coli) and Gram-negative bacterial strains (Pseudomonas aeruginosa).

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Development of chondroitin sulfate-based mucoadhesive interpenetrating polymeric hydrogels of captopril with adjustable properties as gastro-retentive sustained drug release carriers

Qaiser,

Pervaiz,

Hanan

et al. 2023

Polym. Bull.

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Fabrication and evaluation of gelatin-PVA-co-poly(2-acrylamido-2-methylpropane sulfonic acid)-based hydrogels for extended-release of sitagliptin and metformin by employing response surface methodology

Cited by 8 publications

References 37 publications

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

Ellagic Acid Inclusion Complex-Loaded Hydrogels as an Efficient Controlled Release System: Design, Fabrication and In Vitro Evaluation

Development of chondroitin sulfate-based mucoadhesive interpenetrating polymeric hydrogels of captopril with adjustable properties as gastro-retentive sustained drug release carriers

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