Fabrication and Evaluation of Rosuvastatin Calcium Fast- Disintegrating Tablets Using β-Cyclodextrin and Superdisintegrants

Sarfraz, Rai Muhammad; Ahmad, Mahmood; Mahmood, Asif; Minhas, Muhammad Usman; Yaqoob, Ayesha

doi:10.4314/tjpr.v14i11.2

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…The characteristic IR absorption peaks of free ROC were present at 3341.5 cm −1 , 2972.2 cm −1 and 1425.8 cm −1 correspondings to cyclic amines, CH stretching, C=O stretching, O-H bending. These were similar to what has been previously reported in the monograph for rosuvastatin [22]. The characteristic absorption band of ROC appeared in the ROC loaded CANPs, which probably indicate that the ROC molecule was filled in the polymeric network.…”

Section: Resultssupporting

confidence: 90%

Chitosan-sodium Alginate Nanoparticle as a Promising Approach for Oral Delivery of Rosuvastatin Calcium: Formulation, Optimization and In vitro Characterization

Mujtaba

Alotaibi

2020

JPRI

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Rosuvastatin calcium is the most effective antilipidemic drug and is called "super-statin" but it exhibits low aqueous solubility and poor oral bioavailability of about 20%. The present work aimed to develop and optimize chitosan-alginate nanoparticulate formulation of rosuvastatin which can improve its solubility, dissolution and therapeutic efficacy. Chitosan-alginate nanoparticles were prepared by ionotropic pre-gelation of an alginate core followed by chitosan polyelectrolyte complexation and optimization was done in terms of two biopolymers, crosslinker concentrations. The chitosan-alginate nanoparticles were characterized by various techniques such as particle properties such as size; size distribution (polydispersity index); Zeta-potential measurements and Fourier transform infrared spectra respectively. The designed rosuvastatin loaded chitosan-alginate nanoparticle had the average particle size of 349.3 nm with the zeta potential of +29.1 mV, and had high drug loading and entrapment efficiencies. Fourier transform infrared spectra showed no chemical interaction between the rosuvastatin and chitosan-alginate nanoparticle upon the encapsulation of rosuvastatin within the nanoparticles. Nanoparticles revealed a fast release during the first two hours followed by a more gradual drug release during a 24 h period. Hence, our studies demonstrated that the new chitosan-alginate nanoparticle system of rosuvastatin is a promising strategy for improving solubility and in turn, the therapeutic efficacy of rosuvastatin. Therefore, the rosuvastatin-loaded chitosan-alginate nanoparticles are a promising approach for the oral delivery of rosuvastatin.

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Section: Resultssupporting

confidence: 90%

Chitosan-sodium Alginate Nanoparticle as a Promising Approach for Oral Delivery of Rosuvastatin Calcium: Formulation, Optimization and In vitro Characterization

Mujtaba

Alotaibi

2020

JPRI

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“…The stability studies of optimized formulation showed near proximity in hardness, friability, disintegration time and dissolution release profile (25). % drug released showed 86% activity of IR tablets remained after 6 months and % RSD was 5.671 as shown in Table 3.…”

Section: Stability Studies and Statistical Analysismentioning

confidence: 82%

Box Behnken Design: A Statistical Approach to Evaluate the Effect of Crosslinked Carboxymethyl Cellulose and Sodium Starch Glycolate on Release Kinetics of Drug

Hanif¹,

Abbas²,

Rasul³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

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The aim of the study was to evaluate the release kinetics of domperidone maleate (DM) from immediate release (IR) tablets prepared by wet granulation method. Box-Behnken design (BBD) was used to optimize and evaluate the main, interaction and quadratic effects of independent variables i.e. crosslinked carboxymethyl cellulose (CMC) (X 1), sodium starch glycolate (SSG) (X 2) and starch (X 3) on responses R 2 of first order (Y I) and β value of Weibull model (Y 2). Prepared tablets were characterized by various physical tests, invitro drug release, Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). Accelerated stability studies were performed on optimized formulation D9. Y 1 and Y 2 were ranged from 0.9959 to 0.9994 and 0.041 to 0.912 respectively. β value of Weibull model indicated the parabolic shape of the dissolution curve. The quadratic model fits the data well and the resulting equations were used to predict the responses in the Box-Behnken design. FTIR spectra showed the compatibility of DM with CMC and SSG. XRD presented diffraction lines indicates crystalline nature of the drug. DSC thermograms indicated endothermic peak at 220 O C for DM. Stabilities studies revealed that no significant change in hardness, friability, disintegration time and dissolution release profile of DM. It is concluded that a combination of CMC and SSG can be used to enhance the dissolution and release kinetics of IR tablets of DM.

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“…After this weight of the powder was determined and bulk density (ρb) was calculated by using following equation [14]:…”

Section: Bulk Densitymentioning

confidence: 99%

“…It was computed as the ratio of tapped density to bulk density [14]. A value < 1.25 is an indication of good flow of powder while > 1.25 indicates poor flow.…”

Section: Hausner Ratiomentioning

confidence: 99%

Development and <i>in vitro</i> characterization of 5-flurouracilloaded, colon-targeted drug delivery system

Raza¹,

Ranjha²,

Mahmood³

et al. 2018

Trop. J. Pharm Res

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Fabrication and Evaluation of Rosuvastatin Calcium Fast- Disintegrating Tablets Using β-Cyclodextrin and Superdisintegrants

Abstract: Purpose: To formulate fast-disintegrating tablets (FDT) of rosuvastatin calcium (RST) using β-

Cited by 7 publications

References 20 publications

Chitosan-sodium Alginate Nanoparticle as a Promising Approach for Oral Delivery of Rosuvastatin Calcium: Formulation, Optimization and In vitro Characterization

Chitosan-sodium Alginate Nanoparticle as a Promising Approach for Oral Delivery of Rosuvastatin Calcium: Formulation, Optimization and In vitro Characterization

Box Behnken Design: A Statistical Approach to Evaluate the Effect of Crosslinked Carboxymethyl Cellulose and Sodium Starch Glycolate on Release Kinetics of Drug

Development and <i>in vitro</i> characterization of 5-flurouracilloaded, colon-targeted drug delivery system

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