Fabrication and evaluation of self-nanoemulsifying oil formulations (SNEOFs) of Efavirenz

Sahoo, Sabuj; Dash, Gyanada Sankar; Biswal, Satyajeet; Biswal, Prasanta Kumar; Senapati, Prakash Chandra

doi:10.1080/01932691.2018.1472008

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…35 These results concurred with that observed by different studies on self-nanoemulsification. [36][37][38] The optimum o/w nano-emulsion area was produced with a low oil: Smix ratio (1:9, 2:8, 3:7, 4:6) because it provided superior stability and a smaller droplet size; this result was consistent with the data. 39 As a result, these oil: Smix ratios were chosen for further investigation.…”

Section: Pseudo-ternary Phase Diagram Constructionsupporting

confidence: 67%

Self emulsifying drug delivery system: norfloxacin model drug

Abdulkareem,

Sahib

2023

F1000Res

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Background Norfloxacin is a synthetic antibacterial fluoroquinolone that is poorly water soluble and active against a wide spectrum of gram-positive and gram-negative aerobic bacteria. The goal of this work was to create a self-nanoemulsion (SNE) as a colloidal dispersed drug delivery system for increasing norfloxacin dissolving rate, while also assuming intestinal lymphatic transport participation for such a nano-size system that would increase norfloxacin oral bioavailability. Methods Depending on the solubility of norfloxacin in various components, several formulations of liquid SNEDDS of the antibiotic were created using oleic acid (oil), tween20 (surfactant), and PEG200 (co-surfactant). To assess the presence of a nanoemulsion region, phase diagram was generated at various oil: surfactant: co-surfactant ratios. Results The in-vitro dissolution profile suggested an optimum norfloxacin SEDD formulation (F1) comprised of oleic acid (10%), tween 20 (45%), and PEG200 (45%), as opposed to commercially available traditional tablets. The F1 formula exhibited thermodynamic stability with a zeta potential of +60.78mV and a droplet size of 57.4nm. The F1 formula revealed an improved dissolving profile as compared to the commercial Tablet of norfloxacin. Conclusion Based on the findings, this study indicated that preparing norfloxacin as a liquid self-nanoemulsifying system improved the solubility and drug release of norfloxacin counteract the inconsistent bioavailability of the commercial tablet.

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Section: Pseudo-ternary Phase Diagram Constructionsupporting

confidence: 67%

Self emulsifying drug delivery system: norfloxacin model drug

Abdulkareem,

Sahib

2023

F1000Res

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“…The apparent permeability of Lpv was almost an order of higher magnitude after 2 hours compared to the control aqueous-DMSO drug solution [ 76 ]. The self-nano emulsifying oil formulations (SNOFs) of Efz prepared with caproyl 90 and kolliphor EL showed a low percent dissolution efficiency and a high dissolution half-life less than 9 min for Efz under in vitro condition compared to free Efz [ 77 ]. Similarly, low energy water-in-oil NEs of cold-pressed flaxseed oil containing Efz formed using span 20 (28.5%), Tween 80 (28.5%), and ethanol (42.8%) by D-optimised design was found to a stable antiretroviral emulsion [ 78 ].…”

Section: Essential Oil-based Nes/mes Antiviral and Drug Delivery Systmentioning

confidence: 99%

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

Franklyne

Gopinath

Mukherjee

et al. 2021

Current Opinion in Colloid & Interface Science

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Nanoemulsions (NEs) of essential oil (EO) have significant potential to target microorganisms, especially viruses. They act as a vehicle for delivering antiviral drugs and vaccines. Narrowing of drug discovery pipeline and the emergence of new viral diseases, especially, COVID-19 have created a niche to use nanoemulsions (NEs) for augmenting currently available therapeutic options. Published literature demonstrated that EOs have an inherent broad spectrum of activity across bacterial, fungal, and viral pathogens. The emulsification process significantly improved the efficacy of the active ingredients in the EOs. This article highlights the research findings and patent developments in the last two years especially, in EO antiviral activity, antiviral drug delivery, vaccine delivery, viral resistance development, and repurposing EO compounds against SARS-CoV2.

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“…Additionally, the nanometric size of droplets of resultant emulsion provides a large interfacial surface area for penetration. Besides that, the employment of permeability enhancer components in the SNE formulation might improve the intestinal permeation by disturbing the intestinal membrane integrity and increasing its fluidity (25) . In this study, cremophor-EL and PG were used as a surfactant and co-surfactant, respectively.…”

Section: Ex-vivo Permeability Studymentioning

confidence: 99%

Comparison Between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol: Preparation and In-vitro/Ex-vivo Evaluation

Sabri

Hussein²

2020

IJPS

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Nebivolol (NBH) is a third-generation B1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced SNE approach that can address low bioavailability The study aims to prepare nebivolol-loaded Su-SNE by reduction the amount of the prepared conventional SNE to half. Besides, an appropriate polymer type and concentration to prevent NBH precipitation upon oral administration have investigated.. A conventional self-nanoemulsion (formula A) was prepared by dissolving NBH in 500 mg vehicle mixture of imwitor®988: cremophor-EL: propylene glycol. Then, eight Su-SNE formulas with the absence or presence of four different polymers were prepared and evaluated. In-vitro precipitation assay was performed to assess the precipitation inhibition capacity of polymers. The ex-vivo permeation through rat intestinal mucosa was also conducted for determination of permeability parameters. Results revealed that (Su-SNA formula SAS1) containing 5% soluplus could effectively retard the nebivolol precipitation. There was no statistical difference between formula A and SAS1; both maintained a higher apparent NBH concentration for approximately 240 min in 0.1N HCl. The permeation rate of conventional (formula A) and soluplus-based Su-SNE (formula SAS1) was significantly improved, and the permeation enhancement ratio was found 2.7 and 3.2, respectively, as compared with non-formulated NBH. Consequently, it is concluded that developing soluplus-based nebivolol SNE is a promising alternative approach. It can enhance nebivolol stability and permeability with half the amount of conventional SNE components.

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Fabrication and evaluation of self-nanoemulsifying oil formulations (SNEOFs) of Efavirenz

Cited by 8 publications

References 46 publications

Self emulsifying drug delivery system: norfloxacin model drug

Self emulsifying drug delivery system: norfloxacin model drug

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

Comparison Between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol: Preparation and In-vitro/Ex-vivo Evaluation

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