Fabrication and evaluation of stimuli-sensitive xanthan gum-based hydrogel as a potential carrier for a hydrophobic drug ibuprofen

Meena, Priyanka; Singh, Poonam; Warkar, Sudhir G.

doi:10.1007/s00396-023-05198-8

Colloid Polym Sci

2023

DOI: 10.1007/s00396-023-05198-8

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Fabrication and evaluation of stimuli-sensitive xanthan gum-based hydrogel as a potential carrier for a hydrophobic drug ibuprofen

Priyanka Meena,

Poonam Singh,

Sudhir G. Warkar

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Cited by 10 publications

References 47 publications

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Synthesis and Assessment of Acacia Gum‐Based Hydrogel as a Promising Novel Biopolymeric Matrix for Delivery of Ciprofloxacin

Anshul,

Tomar,

Meena

et al. 2024

ChemistrySelect

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In this current study, hydrogels based on acacia gum (AG), polyacrylamide (PAM), and carboxymethyl tamarind kernel gum (CMTKG) were successfully developed and ciprofloxacin (drug) incorporated into it. To optimize the hydrogel, the concentrations of crosslinker and initiator were varied, and their effects on the swelling were examined. The hydrogel was subjected to characterization techniques such as Powder X‐ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), Attenuated Total Reflection‐Fourier Transform Infrared spectroscopy (ATR‐FTIR), and Thermogravimetric analysis (TGA). The hydrogel swelling and in vitro drug release were assessed in pH 1.2 and 7.4 buffer solutions. The findings revealed that an alkaline pH yielded superior results for the swelling and in vitro drug release experiments compared to an acidic pH. The drug release kinetic of the ciprofloxacin‐loaded AG/PAM/CMTKG hydrogel followed the Korsmeyer–Peppas model, demonstrating non‐fickian diffusion at pH 7.4 and fickian mechanism at pH 1.2. The pH‐dependent behavior of ciprofloxacin‐loaded AG/PAM/CMTKG hydrogel displayed its potential implications for site‐specific ciprofloxacin release.

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Synthesis and Assessment of Acacia Gum‐Based Hydrogel as a Promising Novel Biopolymeric Matrix for Delivery of Ciprofloxacin

Anshul,

Tomar,

Meena

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Fabrication and assessment of carboxymethyl guar gum-based sustainable films for packaging application

Juikar,

Warkar

2024

Colloid Polym Sci

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Degradable pH-Sensitive Calcium-Crosslinked Tragacanth Gum/β-Cyclodextrin/Sodium Alginate Hydrogel Microspheres Prepared via Ionotropic Gelation Technique for Hydrophobic Drug Delivery

Meena,

Singh,

Warkar

2024

J Polym Environ

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Fabrication and evaluation of stimuli-sensitive xanthan gum-based hydrogel as a potential carrier for a hydrophobic drug ibuprofen

Cited by 10 publications

References 47 publications

Synthesis and Assessment of Acacia Gum‐Based Hydrogel as a Promising Novel Biopolymeric Matrix for Delivery of Ciprofloxacin

Synthesis and Assessment of Acacia Gum‐Based Hydrogel as a Promising Novel Biopolymeric Matrix for Delivery of Ciprofloxacin

Fabrication and assessment of carboxymethyl guar gum-based sustainable films for packaging application

Degradable pH-Sensitive Calcium-Crosslinked Tragacanth Gum/β-Cyclodextrin/Sodium Alginate Hydrogel Microspheres Prepared via Ionotropic Gelation Technique for Hydrophobic Drug Delivery

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