Fabrication and finite element simulation of antibacterial 3D printed Poly L-lactic acid scaffolds coated with alginate/magnesium oxide for bone tissue regeneration

Angili, Sajad Niazi; Morovvati, M.R.; Kardan-Halvaei, Mostafa; Saber-Samandari, Saeed; Razmjooee, Kavoos; Abed, Azher M.; Toghraie, Davood; Khandan, Amirsalar

doi:10.1016/j.ijbiomac.2022.10.200

Cited by 34 publications

(6 citation statements)

References 51 publications

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“…These cutting-edge developments offer a diverse range of fabrication methods, each with its own unique approach to constructing bioprinting-enabled biomaterials. [46][47][48] 3D printed constructs hold great potential in OA therapy due to their unique capabilities. These constructs can be precisely tailored to match the specific anatomical and mechanical requirements of the affected joint, offering a personalized approach to treatment.…”

Section: Fabrication Methods Of Bioprinting-enabled Biomaterialsmentioning

confidence: 99%

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Yang,

Liu,

Zhang

et al. 2023

IJN

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Bioprinting is an advanced technology that allows for the precise placement of cells and biomaterials in a controlled manner, making significant contributions in regenerative medicine. Notably, bioprinting-enabled biomaterials have found extensive application as drug delivery systems (DDS) in the treatment of osteoarthritis (OA). Despite the widespread utilization of these biomaterials, there has been limited comprehensive research summarizing the recent advances in this area. Therefore, this review aims to explore the noteworthy developments and challenges associated with utilizing bioprinting-enabled biomaterials as effective DDS for the treatment of OA. To begin, we provide an overview of the complex pathophysiology of OA, highlighting the shortcomings of current treatment modalities. Following this, we conduct a detailed examination of various bioprinting technologies and discuss the wide range of biomaterials employed in DDS applications for OA therapy. Finally, by placing emphasis on their transformative potential, we discuss the incorporation of crucial cellular components such as chondrocytes and mesenchymal stem cells into bioprinted constructs, which play a pivotal role in promoting tissue regeneration and repair.

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Section: Fabrication Methods Of Bioprinting-enabled Biomaterialsmentioning

confidence: 99%

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Yang,

Liu,

Zhang

et al. 2023

IJN

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“…Con sively, among the various samples, nitrogen plasma-treated three-dimensional polycap lactone, hydroxyapatite, and magnesium oxide nanoparticles scaffolds displayed highest level of bioactivity based on the team's findings (Figure 17). The study of Angili and his team [225] focused on applying an alginate-MgO material onto a 3D-printed poly L-lactic acid scaffold featuring three different cell The study of Angili and his team [225] focused on applying an alginate-MgO biomaterial onto a 3D-printed poly L-lactic acid scaffold featuring three different cellular structures. Assessments, both mechanical and biological, were conducted on a porous-coated scaffold containing varied concentrations of magnesium oxide nanoparticles, promoting poly L-lactic acid/alginate-20 wt.% magnesium oxide nanoparticle scaffolds as a promising candidate for bone tissue regeneration.…”

Section: Green (Plant-mediated)mentioning

confidence: 99%

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine.

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“…In vitro seeding of osteoblast cells over the nano-biocomposite bead showed favorable viability and gene expressions, inferring its importance in bone tissue engineering and reformative therapies [55]. Angili and co-workers fabricated a 3D-printed poly L-lactic acid scaffold coated with alginate and magnesium oxide nanoparticles with different cellular topologies that not only showed excellent biological biocompatibility, antibacterial activity, and cell survival, but also indicated increasing MgO concentrations enhanced compressive strength and the elastic modulus of the biomaterial, mimicking the process of efficient bone repair and refurbishment [56]. Bone-related diseases, such as osteogenesis imperfecta, arthralgia, congenital malformation, osteoporosis, etc., are often associated with insufficient self-repair and necessitate medical intervention as conventional orthopedic therapeutics suffer shortcomings, such as graft rejection and implant failure.…”

Section: Alginatesmentioning

confidence: 99%

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Banerjee

Madhyastha

2023

JNT

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Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches have been explored in the fields of tissue remodulation and reparation. The engineering of theragnostic nanomaterials has opened up avenues for disease diagnosis, imaging, and therapeutic treatments. The instantaneous monitoring of therapeutic strategy is expected to co-deliver imaging and pharmaceutical agents at the same time, and nanoscale carrier moieties are convenient and efficient platforms in theragnostic applications, especially in soft and hard tissue regeneration. Furthermore, imaging modalities have extensively contributed to the signal-to-noise ratio. Simultaneously, there is an accumulation of high concentrations of therapeutic mediators at the defect site. Given the confines of contemporary bone diagnostic systems, the clinical rationale demands nano/biomaterials that can localize to bone-diseased sites to enhance the precision and prognostic value for osteoporosis, non-healing fractures, and/or infections, etc. Furthermore, bone theragnostics may have an even greater clinical impact and multimodal imaging procedures can overcome the restrictions of individual modalities. The present review introduces representative theragnostic polymeric nanomaterials and their advantages and disadvantages in practical use as well as their unique properties.

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Fabrication and finite element simulation of antibacterial 3D printed Poly L-lactic acid scaffolds coated with alginate/magnesium oxide for bone tissue regeneration

Cited by 34 publications

References 51 publications

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

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