The development of scintillators is of fundamental and industrial meaning for their diverse applications. Despite the great advance in scintillating mono-crystals, challenge remains to search for novel scintillating materials with low cost, large volume, and high efficiency. Here, Tb 3+ -doped glass ceramics (GC) with crystallized Lu 6 O 5 F 8 nano-crystals were prepared and characterized as potential X-ray scintillators. Their structural, optical, and luminescent properties were explored systematically. After thermal treatment, X-ray excited luminescence (XEL) intensity from Lu 6 O 5 F 8 :Tb 3+ GC is greatly increased and the relative intensity is about 64% of commercial BGO scintillator, benefiting from preferential enrichment of Tb 3+ ions into Lu 6 O 5 F 8 nano-crystals with low phonon energy. Moreover, unusual decay behaviors of Tb 3+ emissions in GC sample are observed and discussed. Our results indicate that rare earth doped GC may offer a novel platform for designing and fabricating new scintillating materials in the future.