Fabrication and potential applications of CaCO3–lentinan hybrid materials with hierarchical composite pore structure obtained by self-assembly of nanoparticles

Ma, Xiaoming; Yuan, Shibao; Yang, Lin; Li, Liping; Zhang, Xiaoting; Su, Caiyun; Wang, Kui

doi:10.1039/c3ce41275j

Cited by 27 publications

(13 citation statements)

References 48 publications

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“…CaCO 3 -lentinan microspheres with a hierarchical composite pore structure have been produced by the self-assembly of nanoparticles. These structures could clearly decrease the release rate and prolong the release time of anticancer drugs, reducing potential side effects (Ma et al, 2013a). Hybrid crystals of CaCO 3 with bovine serum (CaCO 3 /BSA) in the shape of a flying plate have been synthesized using nanoparticles.…”

Section: Hybrid and Composite Materialsmentioning

confidence: 99%

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

et al. 2019

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Hybrid materials, or hybrids incorporating both organic and inorganic constituents, are emerging as a very potent and promising class of materials due to the diverse, but complementary nature of the properties inherent of these different classes of materials. The complementarity leads to a perfect synergy of properties of desired material and eventually an end-product. The diversity of resultant properties and materials used in the construction of hybrids, leads to a very broad range of application areas generated by engaging very different research communities. We provide here a general classification of hybrid materials, wherein organics– in -inorganics (inorganic materials modified by organic moieties) are distinguished from inorganics– in –organics (organic materials or matrices modified by inorganic constituents). In the former area, the surface functionalization of colloids is distinguished as a stand-alone sub-area. The latter area—functionalization of organic materials by inorganic additives—is the focus of the current review. Inorganic constituents, often in the form of small particles or structures, are made of minerals, clays, semiconductors, metals, carbons, and ceramics. They are shown to be incorporated into organic matrices, which can be distinguished as two classes: chemical and biological. Chemical organic matrices include coatings, vehicles and capsules assembled into: hydrogels, layer-by-layer assembly, polymer brushes, block co-polymers and other assemblies. Biological organic matrices encompass bio-molecules (lipids, polysaccharides, proteins and enzymes, and nucleic acids) as well as higher level organisms: cells, bacteria, and microorganisms. In addition to providing details of the above classification and analysis of the composition of hybrids, we also highlight some antagonistic yin-&-yang properties of organic and inorganic materials, review applications and provide an outlook to emerging trends.

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Section: Hybrid and Composite Materialsmentioning

confidence: 99%

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

et al. 2019

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“…The geometry of the nanoparticles (e.g., size, pore architecture, shape, and aspect ratio) are critical factors which dictate the fate of the nanoparticle in biological systems. [40, 52, 53] The present study explores the use of surface modified biodegradable V7-RUBY with IR780 dye to identify ovarian cancer using optoacoustic imaging. Of note, tetramethyl orthosilcate (TMOS) was the silica component within the core silica component of the particle.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, the asymmetric conformation of the wormhole pores reduces the exit velocity for released cargo. [40] Nanoparticles with wormhole pores have a longer half-life in the blood, entrap more cargo per size, and have more favorable release kinetics than mesoporous nanoparticles with hexagonally ordered pores. [41] The MSNs of 15 – 50 nm in diameter are considered optimal for cellular uptake with the least possible toxicity.…”

Section: Inroductionmentioning

confidence: 99%

Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle

et al. 2018

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At the intersection of the newly emerging fields of optoacoustic imaging and theranostic nanomedicine, promising clinical progress can be made in dismal prognosis of ovarian cancer. An acidic pH targeted wormhole mesoporous silica nanoparticle (V7-RUBY) was developed to serve as a novel tumor specific theranostic nanoparticle detectable using multispectral optoacoustic tomographic (MSOT) imaging. We report the synthesis of a small, < 40 nm, biocompatible asymmetric wormhole pore mesoporous silica core particle that has both large loading capacity and favorable release kinetics combined with tumor-specific targeting and gatekeeping. V7-RUBY exploits the acidic tumor microenvironment for tumor-specific targeting and tumor-specific release. In vitro, treatment with V7-RUBY containing either paclitaxel or carboplatin resulted in increased cell death at pH 6.6 in comparison to drug alone (p < 0.0001). In orthotopic ovarian xenograft mouse models, V7-RUBY containing IR780 was specifically detected within the tumor 7X and 4X higher than the liver and >10X higher than in the kidney using both multispectral optoacoustic tomography (MSOT) imaging with secondary confirmation using near infrared fluorescence imaging (p < 0.0004). The V7-RUBY system carrying a cargo of either contrast agent or an anti-neoplastic drug has the potential to become a theranostic nanoparticle which can improve both diagnosis and treatment of ovarian cancer.

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“…In the case of the spontaneous deposition strategy, the pre-loading of a negatively charged matrix is crucial for the permission of a positively charged drug to be incorporated within the final fabricated capsules. The pre-loading step includes pre-encapsulation of the matrix material (typically a polyelectrolyte); in which case, this material must have a high affinity to the core (i.e., lentinan [73] or heparin [74]), as well hold some affinity to the drug of interest. This is then followed by the elimination of the core, where the pre-loaded polyelectrolyte remains inside the formed capsule (this step is crucial for both methods).…”

Section: Mechanism Of Lmw Drug Loadingmentioning

confidence: 99%

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

2020

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Polyelectrolyte multilayer capsules (PEMCs) templated onto biocompatible and easily degradable vaterite CaCO3 crystals via the layer-by-layer (LbL) polymer deposition process have served as multifunctional and tailor-made vehicles for advanced drug delivery. Since the last two decades, the PEMCs were utilized for effective encapsulation and controlled release of bioactive macromolecules (proteins, nucleic acids, etc.). However, their capacity to host low-molecular-weight (LMW) drugs (<1–2 kDa) has been demonstrated rather recently due to a limited retention ability of multilayers to small molecules. The safe and controlled delivery of LMW drugs plays a vital role for the treatment of cancers and other diseases, and, due to their tunable and inherent properties, PEMCs have shown to be good candidates for smart drug delivery. Herein, we summarize recent progress on the encapsulation of LMW drugs into PEMCs templated onto vaterite CaCO3 crystals. The drug loading and release mechanisms, advantages and limitations of the PEMCs as LMW drug carriers, as well as bio-applications of drug-laden capsules are discussed based upon the recent literature findings.

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Fabrication and potential applications of CaCO3–lentinan hybrid materials with hierarchical composite pore structure obtained by self-assembly of nanoparticles

Cited by 27 publications

References 48 publications

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

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