Fabrication and properties of poly(vinyl alcohol)/β-tricalcium phosphate composite scaffolds via fused deposition modeling for bone tissue engineering

Chen, Gang; Chen, Ning; Wang, Qi

doi:10.1016/j.compscitech.2019.01.004

Cited by 107 publications

(52 citation statements)

References 47 publications

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“…The most common polymers that are printed via FFF are acrylonitrile-butadiene-styrene (ABS) [ 18 , 19 , 20 ], and poly(lactic acid) (PLA) [ 21 , 22 , 23 ]. However, other polymers such as poly(ether imide) (PEI) [ 24 , 25 , 26 ], polycarbonate (PC) [ 27 , 28 , 29 ], polystyrene (PS) [ 30 , 31 ], polyamide (PA) [ 32 , 33 , 34 ], polypropylene (PP) [ 35 , 36 , 37 ],poly(vinyl alcohol) (PVA) [ 38 , 39 , 40 , 41 ], polyethylene (PE) [ 42 , 43 ], polycaprolactone (PCL) [ 44 , 45 ], polyphenylene sulfide (PPS) [ 46 ], and polymer blends [ 47 , 48 , 49 , 50 , 51 ] have been also studied.…”

Section: Introductionmentioning

confidence: 99%

Fused Filament Fabrication of PEEK: A Review of Process-Structure-Property Relationships

et al. 2020

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Poly (ether ether ketone) (PEEK) is a high-performance engineering thermoplastic polymer with potential for use in a variety of metal replacement applications due to its high strength to weight ratio. This combination of properties makes it an ideal material for use in the production of bespoke replacement parts for out-of-earth manufacturing purposes, in particular on the International Space Station (ISS). Additive manufacturing (AM) may be employed for the production of these parts, as it has enabled new fabrication pathways for articles with complex design considerations. However, AM of PEEK via fused filament fabrication (FFF) encounters significant challenges, mostly stemming from the semi crystalline nature of PEEK and its associated high melting temperature. This makes PEEK highly susceptible to changes in processing conditions which leads to a large reported variation in the literature on the final performance of PEEK. This has limited the adaption of FFF printing of PEEK in space applications where quality assurance and reproducibility are paramount. In recent years, several research studies have examined the effect of printing parameters on the performance of the 3D-printed PEEK parts. The aim of the current review is to provide comprehensive information in relation to the process-structure-property relationships in FFF 3D-printing of PEEK to provide a clear baseline to the research community and assesses its potential for space applications, including out-of-earth manufacturing.

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Section: Introductionmentioning

confidence: 99%

Fused Filament Fabrication of PEEK: A Review of Process-Structure-Property Relationships

et al. 2020

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“…This encouraged the use of 3D printing (also known as rapid prototyping and solid freeform fabrication) technologies to allow the digital CAD design and digital manufacturing of tissue engineering scaffolds [1]. Figure 1 shows the schematic of CAD-designed scaffolds with interconnected macropores and examples of scaffolds fabricated by fused deposition modelling (FDM) [20][21][22][23][24][25][26][27][28][29][30] and stereolithography (SLA) [31][32][33][34][35][36][37][38][39][40][41][42][43][44]. In these scaffolds, the line width W and line spacing S (Figure 1(a)) can be easily tuned, thereby achieving controllable pore geometry, size, and interconnectivity.…”

Section: Origin Principle and Processes Of Low-temperature Depositimentioning

confidence: 99%

“…Figure 1: Examples of interconnected porous tissue engineering scaffolds fabricated by 3D printing technologies. (a) 0°-90°crossing, (b) 0°-60°-120°crossing, (c, d) PCL scaffolds (0°-90°crossing) by fused deposition modelling (FDM), (e, f) PCL scaffolds (0°-60°-120°crossing) by FDM [20], (g, h) poly(D,L)-lactide (PDLLA) scaffolds by stereolithography [32], (i-k) poly(vinyl alcohol)/β-tricalcium phosphate composite scaffold (PVA/β-TCP) by FDM [21], and (l) porous 45S5 bioglass scaffold by SLA [33]. Reproduced with permission.…”

Section: Origin Principle and Processes Of Low-temperature Depositimentioning

confidence: 99%

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Liu

Tong

et al. 2019

Journal of Nanomaterials

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Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

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“…Advocates of this method have risen in recent years because of some reasons like the ability of fabricating complicated pore architecture with different shapes and designs, and providing good capability to have control over porosity, pore size, and stiffness. 8,9 Fused deposition modelling (FDM), 10 selective laser sintering (SLS), 11 and stereolithography (SLA) 12 are some important subcategories of AM technique that fabricate scaffolds directly from a computer-aided design (CAD) file. In spite of their advantages, AM methods have some limitations in many aspects.…”

Section: Introductionmentioning

confidence: 99%

“…Fused deposition modelling (FDM), 10 selective laser sintering (SLS), 11 and stereolithography (SLA) 12 are some important subcategories of AM technique that fabricate scaffolds directly from a computer-aided design (CAD) file. In spite of their advantages, AM methods have some limitations in many aspects.…”

Section: Introductionmentioning

confidence: 99%

Experimental and numerical investigation of polymethyl methacrylate scaffolds for bone tissue engineering

Shirzad

Matbouei

Fathi

et al. 2020

Proceedings of the Institution of Mechanical Engineers, Part L:

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A controversial issue in tissue engineering is the development of new methods to fabricate scaffolds that precisely imitate the structure and function of the extracellular matrix. The objective of this study is to propose a new method in scaffold fabrication and investigate the effects of pore topology, particularly gradient structure, on the mechanical properties of the scaffolds. In this regard, poly(methyl methacrylate) sheets constructing the scaffold's substructures were cut by laser and then stacked on each other. Experimental and numerical methods were utilized to evaluate the mechanical properties of the square and circular scaffolds. The results demonstrate that this method has the ability to fabricate interconnected pores with the controllability on their design. It can also give accurate mechanical properties, especially gradient structure eliminating the weaknesses of simple structures. Moreover, a comparison between the scaffolds showed that opting an appropriate structure can lead to a higher porosity with preferable mechanical properties.

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Fabrication and properties of poly(vinyl alcohol)/β-tricalcium phosphate composite scaffolds via fused deposition modeling for bone tissue engineering

Cited by 107 publications

References 47 publications

Fused Filament Fabrication of PEEK: A Review of Process-Structure-Property Relationships

Fused Filament Fabrication of PEEK: A Review of Process-Structure-Property Relationships

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Experimental and numerical investigation of polymethyl methacrylate scaffolds for bone tissue engineering

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