Fabrication and research of Mg(OH)2/PCL/PVP nanofiber membranes loaded by antibacterial and biosafe Mg(OH)2 nanoparticles

Liu, Yuezhou; Liu, Yanjing; Li, Xiyue; Qian, Yongfang; Lv, Lihua; Wang, Ying

doi:10.1016/j.polymertesting.2022.107635

Cited by 6 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymers also have strong antibacterial properties when used with antibacterial standard medicines for drug delivery systems. That may be related to the partial positive charge on (H-functional group) of PCL that breaks the wall membrane of bacterial cells and interacts 75 , 82 . Myriam et al reported that PCL molecule has a large surface area to interact, so the composites developed by electrospun or 3-D printing techniques show enhanced antibacterial potential against S.aureus and Staphylococcus epidermidis 83 .…”

Section: Discussionmentioning

confidence: 99%

Development of novel polymer haemoglobin based particles as an antioxidant, antibacterial and an oxygen carrier agents

Majid,

Ullah,

Alshehri

et al. 2024

Sci Rep

View full text Add to dashboard Cite

This innovative work aims to develop highly biocompatible and degradable nanoparticles by encapsulating haemoglobin (Hb) within poly-ε-caprolactone for novel biomedical applications. We used a modified double emulsion solvent evaporation method to fabricate the particles. A Scanning electron microscope (SEM) characterized them for surface morphology. Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet–visible spectroscopies (UV–visible) elucidated preserved chemical and biological structure of encapsulated haemoglobin. The airproof equilibrium apparatus obtained the oxygen-carrying capacity and P50 values. The DPPH assay assessed free radical scavenging potential. The antibacterial properties were observed using four different bacterial strains by disk diffusion method. The MTT assay investigates the cytotoxic effects on mouse fibroblast cultured cell lines (L-929). The MTT assay showed that nanoparticles have no toxicity over large concentrations. The well-preserved structure of Hb within particles, no toxicity, high oxygen affinity, P50 value, and IC50 values open the area of new research, which may be used as artificial oxygen carriers, antioxidant, and antibacterial agents, potential therapeutic agents as well as drug carrier particles to treat the cancerous cells. The novelty of this work is the antioxidant and antibacterial properties of developed nanoparticles are not been reported yet. Results showed that the prepared particles have strong antioxidant and antibacterial potential.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of novel polymer haemoglobin based particles as an antioxidant, antibacterial and an oxygen carrier agents

Majid,

Ullah,

Alshehri

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Without incorporating antibacterial properties, PCL and PVP utilization may result in severe infections that necessitate further medical interventions. Thus, to prevent this outcome, it is critical to introduce strong antibacterial agents, for instance, metal and metal oxide nanoparticles, into PCL/PVP nanofibers, thereby conferring them with exceptional antibacterial characteristics (Liu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Copper Oxide Nanoparticles Doped PCL/PVP Nanofibrous Mats by Electrospinning and Evaluation of Their Antibacterial Activities

ERCİ,

BAYRAM SARIİPEK

2023

Kahramanmaraş Sütçü İmam Üniversitesi Mühendislik Bilimleri Dergisi

View full text Add to dashboard Cite

In this study, PCL/PVP/CuO nanofibrous mats for antibacterial applications were fabricated by electrospinning technique using PCL/PVP as a biopolymer matrix and copper oxide nanoparticles (CuONPs) as antimicrobial agents. PCL/PVP/CuO nanofibrous mats were successfully produced by doping different ratios of CuONPs (0.5%, 1%, and 2% wt) into the PCL/PVP solution. The chemical, morphological, and wetting properties of the prepared composite nanofibrous mats were evaluated by FT-IR, FE-SEM analysis, and water contact angle measurements. The morphological investigation indicated that the fiber diameters of the resulting nanofibers decreased as the CuONP content added to the PCL/PVP matrix increased, and the mean fiber diameter value measured for the PCL/PVP/2%CuONPs nanofibrous sample was 186.73. Moreover, wetting behavior of nanofiber surfaces displayed that the incorporation of PVP significantly enhanced the surface wettability of PCL with hydrophobic properties, but the addition of CuONPs to the obtained PCL/PVP matrix decreased it. An in vitro bactericidal assay was performed to investigate the efficacy of PCL/PVP/CuO nanofibrous samples against Staphylococcus aureus. The addition of CuONPs to the fibers led to antibacterial activity, which was found to increase with higher doping ratios. The results showed the potential of PCL/PVP/CuO nanofibrous mats to serve as an effective biomaterial for antibacterial applications.

show abstract

“…Currently, nanofibers of natural and synthetic polymers, such as gelatin (GEL), chitosan (CS), polycaprolactone (PCL), and polyvinylpyrrolidone (PVP), are successfully prepared by electrospinning as biomimetic and temporal substrates to regulate cellular and molecular activities [10][11][12][13]. PCL is a biodegradable semi-crystalline polymer with excellent mechanical properties, it cannot be dissolved in water, and it is easily dissolved in a variety of polar organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of (Sc2O3-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of Escherichia coli Infections

Liu

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Due to their high porosity, large specific surface area, and structural similarity with the extracellular matrix (ECM), electrospun nanofiber membranes are often endowed with the antibacterial properties for biomedical applications. The purpose of this study was to synthesize nano-structured Sc2O3-MgO by doping Sc3+, calcining at 600 °C, and then loading it onto the PCL/PVP substrates with electrospinning technology with the aim of developing new efficient antibacterial nanofiber membranes for tissue engineering. A scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDS) were used to study the morphology of all formulations and analyze the types and contents of the elements, and an X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR) were used for further analysis. The experimental results showed that the PCL/PVP (SMCV-2.0) nanofibers loaded with 2.0 wt% Sc2O3-MgO were smooth and homogeneous with an average diameter of 252.6 nm; the antibacterial test indicated that a low load concentration of 2.0 wt% Sc2O3-MgO in PCL/PVP (SMCV-2.0) showed a 100% antibacterial rate against Escherichia coli (E. coli).

show abstract

Fabrication and research of Mg(OH)2/PCL/PVP nanofiber membranes loaded by antibacterial and biosafe Mg(OH)2 nanoparticles

Cited by 6 publications

References 30 publications

Development of novel polymer haemoglobin based particles as an antioxidant, antibacterial and an oxygen carrier agents

Development of novel polymer haemoglobin based particles as an antioxidant, antibacterial and an oxygen carrier agents

Fabrication of Copper Oxide Nanoparticles Doped PCL/PVP Nanofibrous Mats by Electrospinning and Evaluation of Their Antibacterial Activities

Preparation and Properties of (Sc2O3-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of Escherichia coli Infections

Contact Info

Product

Resources

About