Fabrication, biofunctionalization, and simultaneous multicolor emission of hybrid “dots-on-spheres” structures for specific targeted imaging of cancer cells

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

“…The work includes efforts to tune the photophysical properties of Pdots/CPNs, 109–114 decrease the nonspecific binding of Pdots, 115 expand their biological applications, 73,116,117 and build hybrid nanostructures for imaging cancer cells. 118 Additionally, our group developed a lyophilization process for Pdot bioconjugates, which we hope will facilitate their use by the biomedical community. 61 Fundamental studies of Pdots and CPNs, especially their photophysical properties, are also ongoing, including recent reports by the McNeill group 119–122 and by other research groups.…”

“…While we highlighted recent work in developing and applying different types of Pdots and CPNs, we note there is a large body of work devoted to improving the performance of Pdots and CPNs. The work includes efforts to tune the photophysical properties of Pdots/CPNs, − decrease the nonspecific binding of Pdots, expand their biological applications, ,, and build hybrid nanostructures for imaging cancer cells . Additionally, our group developed a lyophilization process for Pdot bioconjugates, which we hope will facilitate their use by the biomedical community .…”

Synthesis of triphenylamine-containing conjugated polyelectrolyte and fabrication of fluorescence color-changeable, paper-based sensor strips for biothiol detection

“…In addition, we synthesized a hydrophobic polymer (P3) that did not contain sulfonate groups. 62 P3 was also fabricated into a paper-based strip followed by a fluorometric analysis in the presence of Cys in various solvents such as water, methanol, ethanol, acetonitrile, and hexane. Although P3 has an aldehyde group in the backbone, its fluorescence emission color was not changed, mainly because of the failure of the aldehyde and Cys to react.…”

Ratiometric Sensing for Alkaline Phosphatase Based on Two Independent Signals from in Situ Formed Nanohybrids of Semiconducting Polymer Nanoparticles and MnO2 Nanosheets

“…24−28 Recently, extensive attention has been focused on the SPN-based nanohybrids through the assembly of SPNs with inorganic materials because the nanohybrids may display novel sensing properties. 29,30 However, the construction of the SPN-based nanohybrids via postmodification usually encounters some drawbacks, such as complicated preparation process, easy falling off, difficult control of performance, and so forth. Obviously, the in situ preparation of organic–inorganic hybrid SPNs is of great interest to extend their application fields in chemo-/biosensing.…”

“…In recent years, studies on semiconducting polymer nanoparticles (SPNs) in the field of chemo-/biosensing have attracted widespread attention. − Compared to commonly used fluorophores including organic dyes, inorganic nanoparticles, and upconversion materials, SPNs, which mainly consist of π-conjugated polymers, have emerged as excellent candidates and more competent fluorescent probes for constructing chemo-/biosensors because of their excellent performances, such as extraordinary fluorescence brightness, high emission rate, excellent photostability, amplified energy transfer, flexibility, and nontoxicity. − Recently, extensive attention has been focused on the SPN-based nanohybrids through the assembly of SPNs with inorganic materials because the nanohybrids may display novel sensing properties. , However, the construction of the SPN-based nanohybrids via postmodification usually encounters some drawbacks, such as complicated preparation process, easy falling off, difficult control of performance, and so forth. Obviously, the in situ preparation of organic–inorganic hybrid SPNs is of great interest to extend their application fields in chemo-/biosensing.…”