Fabrication, characterization and bioactivity evaluation of calcium pyrophosphate/polymeric biocomposites

El-Kady, Abeer M.; Mohamed, Khaled R.; El‐Bassyouni, Gehan T.

doi:10.1016/j.ceramint.2009.03.042

Cited by 37 publications

(29 citation statements)

References 30 publications

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“…These values of compressive strength were comparable to those of human cancellous bone (Kokubo et al, 2003). As a result, CPP filler powder into the chitosan copolymer matrix containing chitosan or chitosan-gelatin polymer resulted in more effective reinforcement of the composite, then, stiffer composite (El-Kady et al, 2009). The CPC-chitosan composites were more stable in water than conventional calcium phosphate cement (CPC).…”

Section: Propertiessupporting

confidence: 59%

Biocomposite Materials

Khaled¹

2012

Composites and Their Applications

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Section: Propertiessupporting

confidence: 59%

Biocomposite Materials

Khaled¹

2012

Composites and Their Applications

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“…Alumina porous scaffolds were coated with calcium pyrophosphate by impregnating the porous bodies first in calcium hydrogen phosphate dihydrate (CaHPO 4 ·2H 2 O), and then subjecting these bodies to heat treatment at 1100 and 1250°C. This heat treatment was carried out to transform (CaHPO 4 ·2H 2 O) into calcium pyrophosphate . The decomposition of calcium hydrogen phosphate dihydrate (CaHPO 4 ·2H 2 O) to calcium pyrophosphate was taking place according to the following equations …”

Section: Methodsmentioning

confidence: 99%

“…This heat treatment was carried out to transform (CaHPO 4 ·2H 2 O) into calcium pyrophosphate . The decomposition of calcium hydrogen phosphate dihydrate (CaHPO 4 ·2H 2 O) to calcium pyrophosphate was taking place according to the following equations

2 {CaHPO}_{4} . 2 H_{2} O \to 2 {CaHPO}_{4} + 4 H_{2} O ↑

2 {CaHPO}_{4} \to {Ca}_{2} P_{2} O_{7} + H_{2} O

…”

Section: Methodsmentioning

confidence: 99%

Biological Performance of Calcium Pyrophosphate‐coated Porous Alumina Scaffolds

Naga

Awaad

El-Maghraby

et al. 2013

Int J Applied Ceramic Tech

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The present work aims at synthesis and study the bioactivity of porous alumina scaffolds coated with calcium pyrophosphate. Characterization of the formed calcium pyrophosphate and the coated scaffolds was assessed by X-ray diffraction analysis and scanning electron microscope examinations. The in vivo studies revealed the ability of the porous scaffolds to regenerate bone tissue in femur defects of albino rats. Histological analysis showed that the defect is almost entirely filled with new bone. The formed bone is characterized as a mature bone. The produced bone grafts are intended to be used as bone substitute or bone filler.

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“…But no Ca 2 P 2 O 7 appeared on the surface of P‐Mg sample and Mg (OH) 2 was the resulting surface corrosion products for P‐Mg sample after immersion in SBF for 24 h. It is reported that the calcium pyrophosphate is one of the intermediate products in biomineralization process. It had the potential to regulate the onset of calcification and might act as a trigger to promote mineralization in the body . The calcium pyrophosphate, but not apatite product of the SBF immersion might be because of the effects of Mg ions.…”

Section: Resultsmentioning

confidence: 99%

Magnesium metal—A potential biomaterial with antibone cancer properties

Chen

Yang

2013

J Biomedical Materials Res

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Reactive oxygen plays an important role in the pathogenesis of many serious illnesses, including bony cancer. Recently, it has been suggested that hydrogen (H2), a selective antioxidant, can effectively scavenge free radicals. Biomedical magnesium (Mg) used for bone defect repair in the surgery of bony cancer could release H2 because of the degradation, so Mg might have the potential to prevent bony cancer from metastasis and recurrence. In this study, alkali-heat treatment method was employed to modify the surface structure of Mg metal, so as to control the degradation of Mg metal and the H2 releasing rate. Then the released H2 was introduced to the Fenton Reaction system to detect its effect on scavenging free radicals. The modified Mg metal was employed as the substrate for bone cancer cell culture to study the effect of the H2 releasing on scavenging free radicals in the cells. It is found that the H2 released from the Mg degradation could scavenge free radicals both in the Fenton Reaction system and bone cancer cells. The effect on the scavenging free radical is proportional to the rate of H2 releasing. It suggested that Mg might be a potential material with anti-bone cancer properties. It is hopeful to both repair the bone defect and prevent bony cancer from metastasis and recurrence for the bony cancer patients by biomedical Mg metal.

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Fabrication, characterization and bioactivity evaluation of calcium pyrophosphate/polymeric biocomposites

Cited by 37 publications

References 30 publications

Biocomposite Materials

Biocomposite Materials

Biological Performance of Calcium Pyrophosphate‐coated Porous Alumina Scaffolds

Magnesium metal—A potential biomaterial with antibone cancer properties

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