Fabrication, characterization and evaluation of bioceramic hollow microspheres used as microcarriers for 3-D bone tissue formation in rotating bioreactors

Qiu, Qingqing; Ducheyne, Paul; Ayyaswamy, P. S.

doi:10.1016/s0142-9612(98)00183-5

Cited by 132 publications

(64 citation statements)

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“…When the conjugate matrix-cells are deployed within a human body, for example, it is expected that this conjugate will be consistent with the tissue, providing support and leading to desirable cell proliferation. 19 As cell proliferation and differentiation are occurring, the scaffold slowly biodegrades, gradually allowing the contact of blood vessels and host cytokine with the cells. What was once a matrix-cell conjugate changes, gradually making room for new and desired tissue as regeneration occurs.…”

Section: Overview Of Tissue Engineeringmentioning

confidence: 99%

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Tonelli¹,

Santos²,

Gomes³

et al. 2012

IJN

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Abstract:In recent years, significant progress has been made in organ transplantation, surgical reconstruction, and the use of artificial prostheses to treat the loss or failure of an organ or bone tissue. In recent years, considerable attention has been given to carbon nanotubes and collagen composite materials and their applications in the field of tissue engineering due to their minimal foreign-body reactions, an intrinsic antibacterial nature, biocompatibility, biodegradability, and the ability to be molded into various geometries and forms such as porous structures, suitable for cell ingrowth, proliferation, and differentiation. Recently, grafted collagen and some other natural and synthetic polymers with carbon nanotubes have been incorporated to increase the mechanical strength of these composites. Carbon nanotube composites are thus emerging as potential materials for artificial bone and bone regeneration in tissue engineering.

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Section: Overview Of Tissue Engineeringmentioning

confidence: 99%

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Tonelli¹,

Santos²,

Gomes³

et al. 2012

IJN

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“…The National Aeronautics and Space Administration developed a bioreactor of rotating wall vessels (RWVs) for the evaluation of cell proliferation and function in microgravity conditions [15]. With an RWV bioreactor, hepatocytes [15], bone marrow cells [16][17][18], stem cells [19], chondrocytes [20] and osteoblasts [21] have been cultured and used for the formation of organoids and tissues. Brown et al [15] cultured hepatocytes in an RWV and reported that the resulting organoids exhibited liver-like functions.…”

Section: Gravity Controlmentioning

confidence: 99%

“…The resulting organoid showed a high expression of cartilage markers, including aggrecan and collagen type II, compared with chondrocytes in a flat culture. Bone marrow cells were also cultured in an RWV in the presence of bioceramic microspheres [18]. In addition, Okamura et al [19] cultured hepatic stem/progenitor cells in an RWV bioreactor to mimic the condition of microgravity.…”

Section: Gravity Controlmentioning

confidence: 99%

Assembly of cells and vesicles for organ engineering

Taguchi

2011

Science and Technology of Advanced Materials

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The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissues in vitro and in vivo. Cartilage, bone and skin have been successfully regenerated in vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organs in vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration.

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“…The advantage of using an RWV bioreactor for tissue formation was first reviewed by Unsworth and Lelkes (1998), who discussed the benefits of growing tissues in microgravity and simulated microgravity. The formation of tissue by, for example, endothelial cells (Sanfold et al, 2002), colon carcinoma cell lines (Goodwin et al, 1992), ovarian cancer cells (Goodwin et al, 1997), osteoblasts (Qiu et al, 1999), and erythroid cells (Sytkowski and Davis, 2001), has been reported. In particular, the RWV bioreactor has been shown to stimulate chondrogenesis (Baker and Goodwin, 1997;Duke et al, 1993).…”

Section: Rwv (Rotating Wall Vessel) Bioreactormentioning

confidence: 99%

Tissue Engineering for Tissue and Organ Regeneration

Eberli¹

2011

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Fabrication, characterization and evaluation of bioceramic hollow microspheres used as microcarriers for 3-D bone tissue formation in rotating bioreactors

Cited by 132 publications

References 0 publications

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Assembly of cells and vesicles for organ engineering

Tissue Engineering for Tissue and Organ Regeneration

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