Fabrication, characterization and fracture study of a machinable hydroxyapatite ceramic

Shareef, Mohammed Y; Messer, P. F.; Noort, Richard van

doi:10.1016/0142-9612(93)90078-g

Cited by 60 publications

(30 citation statements)

References 6 publications

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“…Corresponding porosity values have been reported by different investigators (Peelen et al 1978;Akao et al 1981;de With et al 1981;Shareef et al 1993;Arita et al 1995;Martin & Brown 1995;Liu 1998;Charrière et al 2001), see tables 3 and 4. Elastic properties of HA biomaterials were determined through uniaxial quasistatic mechanical tests (Akao et al 1981;Charrière et al 2001), but also through ultrasonic techniques (de With et al 1981;Liu 1998), or resonance frequency tests (Arita et al 1995).…”

Section: (C) Biomaterial-specific Porosities-experimental Set Iiamentioning

confidence: 99%

“…The authors are not aware of direct strength tests on pure HA (with f = 0). Therefore, we consider one uniaxial tensile test, S ult,t exp = 37.1 MPa, and one uniaxial compressive test, S ult,c exp = 509 MPa, on fairly dense samples (with f = 12.2% and 2.8%, respectively), conducted by Shareef et al (1993) and Akao et al (1981), respectively (table 4). From these two tests, we back-calculate, via evaluation of equations (3.7)-(3.11) for S = S ult,t exp e 3 ⊗ e 3 and S = −S ult,c exp e 3 ⊗ e 3 , the universal tensile and shear strength of pure HA, s ult,t HA and s ult,s HA (table 2).…”

Section: Model Validation (A) Strategy For Model Validation Through Imentioning

confidence: 99%

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The role of disc-type crystal shape for micromechanical predictions of elasticity and strength of hydroxyapatite biomaterials

Fritsch

Hellmich

Dormieux

2010

Phil. Trans. R. Soc. A.

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The successful design of ceramic bone biomaterials is challenged by two competing requirements: on the one hand, such materials need to be stiff and strong, which would suggest a low porosity (of pore sizes in the 10-100 mm range) to be targeted; on the other hand, bone biomaterials need to be bioactive (in particular vascularized), which suggests a high porosity of such materials. Conclusively, reliable information on how porosity drives the stiffness and strength properties of ceramic bone biomaterials (tissue engineering scaffolds) is of great interest. In this context, mathematical models are increasingly being introduced into the field. Recently, self-consistent continuum micromechanics formulations have turned out as expressedly efficient and reliable tools to predict hydroxyapatite biomaterials' stiffness and strength, as a function of the biomaterialspecific porosity, and of the 'universal' properties of the individual hydroxyapatite crystals: their stiffness, strength and shape. However, the precise crystal shape can be suitably approximated by specific ellipsoidal shapes: while it was shown earlier that spherical shapes do not lead to satisfactory results, and that acicular shapes are an appropriate choice, we here concentrate on disc-type crystal shape as, besides needles, plates are often reported in micrographs of hydroxyapatite biomaterials. Discbased model predictions of a substantial set of experimental data on stiffness and strength of hydroxyapatite biomaterials almost attain the quality of the very satisfactory needle-based models. This suggests that, as long as the crystal shape is clearly nonspherical, its precise shape is of secondary importance if stiffness and strength of hydroxyapatite biomaterials are predicted on the basis of continuum micromechanics, from their micromorphology and porosity.

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Section: (C) Biomaterial-specific Porosities-experimental Set Iiamentioning

confidence: 99%

Section: Model Validation (A) Strategy For Model Validation Through Imentioning

confidence: 99%

The role of disc-type crystal shape for micromechanical predictions of elasticity and strength of hydroxyapatite biomaterials

Fritsch

Hellmich

Dormieux

2010

Phil. Trans. R. Soc. A.

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“…It should be noted that a wide range of values has been proposed in different studies: with the TC molecule values ranging from 0.35 to 12 GPa (Gautieri et al, 2011;Sun et al, 2002) and from 62.75 to 170 GPa for HA mineral (Weiner and Wagner, 1998;Cowin, 1989;Currey, 1969). The failure properties of TC molecules and mineral reported in literature (Akao et al, 1981;Shareef et al, 1993) are shown in Table 1.…”

Section: Mineralized Collagen Microfibrilmentioning

confidence: 99%

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Barkaoui¹,

Hambli²,

Tavares³

2014

Computer Methods in Biomechanics and Biomedical Engineering

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Bone is a multiscale heterogeneous material and its principal function is to support the body structure and to resist mechanical loads without fracturing. Numerical modelling of biocomposites at different length scales provides an improved understanding of the mechanical behaviour of structures such as bone, and also guides the development of multiscale mechanical models. Here, a three-dimensional nano-scale model of mineralized collagen microfibril based on the finite element method was employed to investigate the effect of material and structural factors on the mechanical equivalent of fracture properties.

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“…Calcium phosphate based bioceramics have recently received special attention as bone replacement materials, as they behave similarly to the mineral constituent of bones (Martin and Brown 1995, Felício-Fernandes and Laranjeira 2000, Pereira et al 1999, Kawachi et al 2000, Shareef et al 1993, Sivakumar et al 1996.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration

Finisie

Josué

Fávere

et al. 2001

An. Acad. Bras. Ciênc.

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Bioceramic composites were obtained from chitosan and hydroxyapatite pastes synthesized at physiological temperature according to two different syntheses approaches. Usual analytical techniques (X-ray diffraction analysis, Fourier transformed infrared spectroscopy, Thermo gravimetric analysis, Scanning electron microscopy, X-ray dispersive energy analysis and Porosimetry) were employed to characterize the resulting material. The aim of this investigation was to study the bioceramic properties of the pastes with nondecaying behavior from chitosan-hydroxyapatite composites. Chitosan, which also forms a water-insoluble gel in the presence of calcium ions, and has been reported to have pharmacologically beneficial effects on osteoconductivity, was added to the solid phase of the hydroxyapatite powder. The properties exhibited by the chitosan-hydroxyapatite composites were characteristic of bioceramics applied as bone substitutes. Hydroxyapatite contents ranging from 85 to 98% (w/w) resulted in suitable bioceramic composites for bone regeneration, since they showed a non-decaying behavior, good mechanical properties and suitable pore sizes.

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Fabrication, characterization and fracture study of a machinable hydroxyapatite ceramic

Cited by 60 publications

References 6 publications

The role of disc-type crystal shape for micromechanical predictions of elasticity and strength of hydroxyapatite biomaterials

The role of disc-type crystal shape for micromechanical predictions of elasticity and strength of hydroxyapatite biomaterials

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration

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