Fabrication, characterization, stability and re-dispersibility of curcumin-loaded gliadin-rhamnolipid composite nanoparticles using pH-driven method

Chen, Shuai; Ma, Yong; Dai, Lei; Liao, Wenyan; Zhang, Liang; Liu, Jinfang; Gao, Yanxiang

doi:10.1016/j.foodhyd.2021.106758

Cited by 83 publications

(36 citation statements)

References 49 publications

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“…As the content of TP decreased, the zeta-potential of composite zein/TP NPs gradually increased, that is, the absolute value of zeta-potential gradually decreased. Chen et al (2021) also found a similar phenomenon that with the increase of rhamnolipid content, the zeta-potential of gliadin-rhamnolipid nanoparticles gradually increased. Zeta-potential is a vital parameter to characterize the stability of nanoparticles suspension.…”

Section: Resultssupporting

confidence: 59%

“…The photostability of curcumin encapsulated in zein NPs and zein/TP NPs was evaluated using an ultraviolet light lamp on the basis of Chen et al (2021) with minor modifications. In brief, 10 mL freshly prepared samples of curcumin-loaded zein/TP NPs were placed in the clear glass bottles, which were exposed to UV light (0.35 W/m 2 ) for 30, 60, 90 and 120 min at room temperature.…”

Section: Methodsmentioning

confidence: 99%

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Tremella polysaccharides-coated zein nanoparticles for enhancing stability and bioaccessibility of curcumin

Wei

Sun

et al. 2022

Current Research in Food Science

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Section: Resultssupporting

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Tremella polysaccharides-coated zein nanoparticles for enhancing stability and bioaccessibility of curcumin

Wei

Sun

et al. 2022

Current Research in Food Science

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“…Besides, the sizes of the re-dispersed Res-zein-MSC NPs ranged from 167.30 to 172.63 nm with a uniform size distribution (PDI < 0.25) (Table 1). A similar phenomenon was also observed in a previous literature whereby the particle size of curcumin-loaded gliadin-rhamnolipid composite nanoparticles decreased after re-dispersion [28]. The absolute zeta-potential values of Res-zein-MSC NPs increased after re-dispersion (−35.27~−38.87 mV), showing a stronger electrostatic repulsion among the re-dispersed nanoparticles [29].…”

Section: Characterization Of Res-zein-msc Npssupporting

confidence: 88%

A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

Liu

Zhang

Liu

et al. 2021

Foods

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A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanoparticles (Res-zein-MSC NPs) with varying zein to Res mass ratios was first prepared. The particle sizes and zeta-potentials were in the ranges from 215.00 to 225.00 nm and from −29.00 to −31.00 mV. The encapsulation efficiency (EE) of Res was also influenced by the zein to Res mass ratio, and the encapsulated Res existed in an amorphous form. The major interactions between Res and zein-MSC NPs were hydrogen bonding and hydrophobic interaction. Furthermore, compared with free Res, the photo-stability and bioaccessibility of Res-zein-MSC NPs were significantly improved. The cellular studies also showed that Res-zein-MSC NPs exhibited lower cytotoxicity and desirable anti-inflammatory activity.

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“…The best results in terms of mean diameter and size distribution were obtained following the nanoprecipitation of 1 mg/mL of protein and 0.1% w/v of SRO2 as stabilizer [35]. The obtained gliadin nanoparticles efficiently retained the hydrophilic compounds, which was surprising because the protein is made up of several lipophilic amino acid residues, and up to now, few examples of a water-soluble compound entrapped within gliadin colloidal systems have been reported [39,40].…”

Section: Resultsmentioning

confidence: 99%

Influence of the Physico-Chemical Properties of Model Compounds on the Mean Sizes and Retention Rate of Gliadin Nanoparticles

2021

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Vegetal proteins have emerged as appealing starting materials for the development of various drug delivery systems, and their use for obtaining polymeric nanoparticles has been profitably exploited in multidisciplinary fields. Wheat gliadin, the water-insoluble storage protein of gluten, is characterized by a great amount of hydrophobic amino acid residues and notable mucoadhesive features. This biopolymer can be easily manipulated to form colloidal carriers, films and fibers by means of bio-acceptable solvents and easy preparation procedures. In this investigation, four model compounds characterized by different octanol/water partition coefficient (logP) values were encapsulated in gliadin nanoparticles, with the aim of investigating the influence of their physico-chemical properties on the cargo features and technological characteristics of the protein nanocarriers. The results demonstrate that the chemical structure, solubility and molecular weight of the compounds used are able to dramatically modulate the mean sizes and the entrapment efficiency of gliadin nanoparticles. This demonstrates the importance of a preformulation investigation when a molecule needs to be encapsulated in this type of polymeric carrier.

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Fabrication, characterization, stability and re-dispersibility of curcumin-loaded gliadin-rhamnolipid composite nanoparticles using pH-driven method

Cited by 83 publications

References 49 publications

Tremella polysaccharides-coated zein nanoparticles for enhancing stability and bioaccessibility of curcumin

Tremella polysaccharides-coated zein nanoparticles for enhancing stability and bioaccessibility of curcumin

A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

Influence of the Physico-Chemical Properties of Model Compounds on the Mean Sizes and Retention Rate of Gliadin Nanoparticles

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