Fabrication, Design and Characterization of 1D Nano-Fibrous SiO2 Surface by a Facile and Scalable Method

Abstract

In this paper, new 1D nano-fibrous SiO2 with functionalized surfaces is prepared. First, the effect of dispersion on the morphology and the surface properties of the silica SiO2 compounds are investigated. Second, energy dispersive spectrometer (EDS) and variable pressure scanning electron microscope (VP-SEM) show typically pure and fibrous texture on the surface of SiO2. Third, the presence of the bridging oxygen stretching vibration Si–O–Si, as well as the increase in the intensity ratio between Si-OH band and Si-O-Si are revealed by (FTIR) spectroscopy. Furthermore, X-ray diffraction (XRD) validates the conservation of the SiO lattice after chemical treatment through the KOH for both dispersed and non-dispersed samples. In addition, the shift of the XRD main peak (101) is in good agreement with the FTIR results showing the shift of Si-O-Si peak and the increase in the intensity ratio of Si-OH/Si-O-Si. The dispersed SiO2 sample exhibits a promising functionalized surface with satisfactory results in terms of silica nanofibers crystallinity and chemical composition. As a result, gigh resolution transmission electron microscopy (HR-TEM) data corroborate the claim of the presence of SiO2 nanofibers on the surface from 20nm to 250nm. New nano-fibrous SiO2 surfaces will be used to improve interfacial bonding strength between SiO2 compounds and polymer (or organic materials).

Enhancing therapeutic efficacy: sustained delivery of 5-fluorouracil (5-FU) via thiolated chitosan nanoparticles targeting CD44 in triple-negative breast cancer

“…The surface chemistry and precise microstructure of Empty HA-ThCs and HA-coated 5-FU in ThCs-NPs were observed through SEM using MIRA3 (TESCAN, Czech Republic). Using lyophilized powder of nanoparticles by fixing on aluminium stubs with gold coating, images were captured at a 15 kV voltage using accelerated electrons 32 .…”

“…The surface chemistry and precise microstructure of Empty HA-ThCs and HA-coated 5-FU in ThCs-NPs were observed through SEM using MIRA3 (TESCAN, Czech Republic). Using lyophilized powder of nanoparticles by fixing on aluminium stubs with gold coating, images were captured at a 15 kV voltage using accelerated electrons 32 . To examine nanoparticles to confirm drug loading and determine morphology (shape and size), TEM with specifications of JEOL/JEM 2100, Akishima, Tokyo, Japan, was used.…”

In silico ADMET profiling of Docetaxel and development of camel milk derived liposomes nanocarriers for sustained release of Docetaxel in triple negative breast cancer

“…A small amount of lyophilized sample was fixed on SEM stub (aluminium) followed by gold coating. Prior to analysis, excess powder was removed by taping gently 14 .…”

Green synthesis of hyaluronic acid coated, thiolated chitosan nanoparticles for CD44 targeted delivery and sustained release of Cisplatin in cervical carcinoma

“…A small amount of lyophilized powder was fixed on aluminium stubs followed by coating with gold. SEM images of nanoparticles were taken using accelerated electrons with 15 kV voltage to image samples at nanometer scale resolution ( Khouchaf and Oufakir, 2022 ).…”

“…Transmission electron microscopy (TEM) [with (JEOL/JEM 2100, Akishima, Tokyo, Japan)] was used for analysis of NPs to determine size, shape, and confirm drug loading in nanoparticles. A single drop of blank HA-ThCs and HA-ThCs-Cis was dried on a copper grid and images were taken by operating at a voltage of 200 kV ( Khouchaf and Oufakir, 2022 ).…”