Fabrication of a conduit for future peripheral nerve regeneration using decellularized plant tissue modified with polyaniline/graphene oxide nanosheet

Zaman, Mohammad Sadegh; Khosravieh, Zahra Fakhraei; Ahssan, Mozhan; Salehiamin, Mehdi; Ghoraishizadeh, Saman; Darvishnia, Fatemeh; Rahmani, Erfan; Esmaeili, Javad

doi:10.1016/j.mtcomm.2024.109204

Materials Today Communications

2024

DOI: 10.1016/j.mtcomm.2024.109204

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Fabrication of a conduit for future peripheral nerve regeneration using decellularized plant tissue modified with polyaniline/graphene oxide nanosheet

Mohammad Sadegh Zaman,

Zahra Fakhraei Khosravieh,

Mozhan Ahssan

et al.

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Cited by 3 publications

References 48 publications

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Decellularized Biohybrid Nerve Promotes Motor Axon Projections

Mehta,

Zhang,

Xie

et al. 2024

Adv Healthcare Materials

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Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, biohybrid nerves are developed using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4‐ethylenedioxythiophene) (PEDOT). Nine biohybrid nerves are compared with varying polymerization conditions and cycles, selecting the best candidate through material characterization. These results show that a 1:1 ratio of FeCl3 oxidant to ethylenedioxythiophene (EDOT) monomer, cycled twice, provides superior conductivity (>0.2 mS cm−1), mechanical alignment, intact mesostructures, and high compatibility with cells and blood. To test the biohybrid nerve's effectiveness in promoting motor axon growth, human Spinal Cord Spheroids (hSCSs) derived from HUES 3 Hb9:GFP cells are used, with motor axons labeled with green fluorescent protein (GFP). Seeding hSCS onto one end of the conduit allows motor axon outgrowth into the biohybrid nerve. The construct effectively promotes directed motor axon growth, which improves significantly after seeding the grafts with Schwann cells. This study presents a promising approach for reconstructing axonal tracts in humans.

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Decellularized Biohybrid Nerve Promotes Motor Axon Projections

Mehta,

Zhang,

Xie

et al. 2024

Adv Healthcare Materials

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From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair

Borah,

Diez Clarke,

Upadhyay

et al. 2025

Materials Today Bio

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Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

Gostaviceanu,

Gavrilaş,

Copolovici

et al. 2024

IJMS

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This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides and proteins. GO, a versatile nanomaterial with oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity and environmental impact. Peptides and proteins can be functionalized on GO surfaces through various methods, including non-covalent interactions such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, and van der Waals forces, as well as covalent bonding through reactions involving amide bond formation, esterification, thiol chemistry, and click chemistry. These approaches enhance GO’s functionality in several key areas: biosensing for sensitive biomarker detection, theranostic imaging that integrates diagnostics and therapy for real-time treatment monitoring, and targeted cancer therapy where GO can deliver drugs directly to tumor sites while being tracked by imaging techniques like MRI and photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering and aiding tissues’ bone, muscle, and nerve tissue regeneration, while their antimicrobial properties are improving infection-resistant medical devices. Despite its potential, addressing challenges related to stability and scalability is essential to fully harness the benefits of GBMs in healthcare.

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Fabrication of a conduit for future peripheral nerve regeneration using decellularized plant tissue modified with polyaniline/graphene oxide nanosheet

Cited by 3 publications

References 48 publications

Decellularized Biohybrid Nerve Promotes Motor Axon Projections

Decellularized Biohybrid Nerve Promotes Motor Axon Projections

From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair

Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

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