Fabrication of a Multifunctional Nano‐in‐micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix

Zhang, Hongbo; Liu, Dongfei; Shahbazi, Mohammad‐Ali; Mäkilä, Ermei; Herranz-Blanco, Bárbara; Salonen, Jarno; Hirvonen, Jouni; Santos, Hélder A.

doi:10.1002/adma.201400953

Cited by 141 publications

(99 citation statements)

References 27 publications

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“…A major challenge in producing microencapsulated products is ensuring particle size monodispersity, [ 26,27 ] which can have a large effect on drug release characteristics with respect to an intended target organ. [ 28,29 ] In addition to size monodispersity, having well-defi ned microstructures plays an important role in exploring widespread applications.…”

Section: Doi: 101002/adfm201502322mentioning

confidence: 99%

Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery

Mundargi

Potroz

Park

et al. 2015

Adv Funct Materials

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Herein, the exploration of natural plant‐based “spores” for the encapsulation of macromolecules as a drug delivery platform is reported. Benefits of encapsulation with natural “spores” include highly uniform size distribution and materials encapsulation by relatively economical and simple versatile methods. The natural spores possess unique micromeritic properties and an inner cavity for significant macromolecule loading with retention of therapeutic spore constituents. In addition, these natural spores can be used as advanced materials to encapsulate a wide variety of pharmaceutical drugs, chemicals, cosmetics, and food supplements. Here, for the first time a strategy to utilize natural spores as advanced materials is developed to encapsulate macromolecules by three different microencapsulation techniques including passive, compression, and vacuum loading. The natural spore formulations developed by these techniques are extensively characterized with respect to size uniformity, shape, encapsulation efficiency, and localization of macromolecules in the spores. In vitro release profiles of developed spore formulations in simulated gastric and intestinal fluids have also been studied, and alginate coatings to tune the release profile using vacuum‐loaded spores have been explored. These results provide the basis for further exploration into the encapsulation of a wide range of therapeutic molecules in natural plant spores.

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Section: Doi: 101002/adfm201502322mentioning

confidence: 99%

Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery

Mundargi

Potroz

Park

et al. 2015

Adv Funct Materials

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show abstract

“…19,20 Furthermore, the synergistic effect of the multistage delivery system endowed the carriers with reduced burst release and subsequently demonstrated the sustained release profile of the hydrophobic model drug ibuprofen. Although the success of similar multistage systems utilizing porous silicon particles in various polymer matrices has been encouraging, 21,22 the absolute safety of the silicon particles in those studies remains a concern. 23 In contrast, PEG-PLGA multistage vehicles offer additional benefits, such as excellent biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26][27] Droplet microfluidic technology provides a method to generate highly monodisperse particles with a precisely controllable size and morphology. 21,[28][29][30] In addition to fabricating uniformly sized spheres that might be crucial for physiological interactions of the encased therapeutics, 25 microfluidics provide added benefits, such as the flexibility in material selection and chemical compositions, the ability to simultaneously encapsulate different cargos, and a nearly 100% theoretical encapsulation efficiency. 25,29,[31][32][33][34] Equipped with the numerous advantages afforded by droplet-based microfluidics, the multistage design described in this study can be widely applied in long-term and multi-functional delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites

et al. 2015

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The poor solubility of many newly discovered drugs has resulted in numerous challenges for the time-controlled release of therapeutics. In this study, an advanced drug delivery platform to encapsulate and deliver hydrophobic drugs, consisting of poly (lactic-co-glycolic acid) (PLGA) nanoparticles incorporated within poly (ethylene glycol) (PEG) microgels, was developed. PLGA nanoparticles were used as the hydrophobic drug carrier, while the PEG matrix functioned to slow down the drug release. Encapsulation of the hydrophobic agents was characterized by fluorescence detection of the hydrophobic dye Nile Red within the microgels. In addition, the microcomposites prepared via the droplet-based microfluidic technology showed size tunability and a monodisperse size distribution, along with improved release kinetics of the loaded cargo compared with bare PLGA nanoparticles. This composite system has potential as a universal delivery platform for a variety of hydrophobic molecules. V C 2015 AIP Publishing LLC.

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“…This method is based on the absorption characteristics of the aqueous solutions at the wavelength of 1520 nm in the + 3 absorption band of water. The wavelength of 1520 nm is an isosbestic point for the aqueous solutions of the acid and alkali with respect to their concentrations while the absorbance of the salt solutions at 1520 nm vary with their salt concentrations.…”

Section: Visualization Of Concentrations Of Salts Produced During Neumentioning

confidence: 99%

Visualization of Concentrations of Salts Produced during Neutralization Reactions by using Single Wavelength in the Near-infrared Region

Kawashima¹,

Kakuta²,

Arimoto³

et al. 2016

TVSJ

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This paper proposes a novel imaging method using near infrared light of single wavelength to visualize the concentration distribution of salt generated by neutralization reaction of aqueous solutions of acid and alkali in a microfluidic channel. This method is based on the absorption characteristics of the aqueous solutions at the wavelength of 1520 nm in the + 3 absorption band of water. The wavelength of 1520 nm is an isosbestic point for the aqueous solutions of the acid and alkali with respect to their concentrations while the absorbance of the salt solutions at 1520 nm vary with their salt concentrations.To verify the proposed single-wavelength imaging method, the concentration images of sodium chloride (NaCl) were obtained and analyzed in two cases of the combinations of two liquids flowing into a T-shaped microchannel: (i) water and aqueous solution of NaCl, and (ii) hydrochloric acid and sodium hydroxide. The measured concentrations of NaCl agreed well with the expected distributions of the concentrations and verified the proposed method.

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Fabrication of a Multifunctional Nano‐in‐micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix

Cited by 141 publications

References 27 publications

Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery

Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery

Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites

Visualization of Concentrations of Salts Produced during Neutralization Reactions by using Single Wavelength in the Near-infrared Region

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