Fabrication of a new photoluminescent and pH-responsive nanocomposite based on a hyperbranched polymer prepared from amino acid for targeted drug delivery applications

Aslani, Robab; Namazi, Hassan

doi:10.1016/j.ijpharm.2023.122804

Cited by 9 publications

(2 citation statements)

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“…This significantly enhances the therapeutic effect of drugs and reduces their adverse reactions. Nanopolymers are often prepared by connecting pH-responsive broken chemical bonds, and commonly used pH-responsive bonds include 2, 3-dimethyl maleic anhydride, benzoimine bond, thiopropionate bond, hydrazone bond, imine bond, protonate bond, keto, limonic anhydride, acetal and cycloacetal ( Aslani and Namazi, 2023 ).…”

Section: Controlled Release Of Nanogelsmentioning

confidence: 99%

Smart nanogels for cancer treatment from the perspective of functional groups

Yu,

Liu,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: Cancer remains a significant health challenge, with chemotherapy being a critical treatment modality. However, traditional chemotherapy faces limitations due to non-specificity and toxicity. Nanogels, as advanced drug carriers, offer potential for targeted and controlled drug release, improving therapeutic efficacy and reducing side effects.Methods: This review summarizes the latest developments in nanogel-based chemotherapy drug delivery systems, focusing on the role of functional groups in drug loading and the design of smart hydrogels with controlled release mechanisms. We discuss the preparation methods of various nanogels based on different functional groups and their application in cancer treatment.Results: Nanogels composed of natural and synthetic polymers, such as chitosan, alginate, and polyacrylic acid, have been developed for chemotherapy drug delivery. Functional groups like carboxyl, disulfide, and hydroxyl groups play crucial roles in drug encapsulation and release. Smart hydrogels have been engineered to respond to tumor microenvironmental cues, such as pH, redox potential, temperature, and external stimuli like light and ultrasound, enabling targeted drug release.Discussion: The use of functional groups in nanogel preparation allows for the creation of multifunctional nanogels with high drug loading capacity, controllable release, and good targeting. These nanogels have shown promising results in preclinical studies, with enhanced antitumor effects and reduced systemic toxicity compared to traditional chemotherapy.Conclusion: The development of smart nanogels with functional group-mediated drug delivery and controlled release strategies represents a promising direction in cancer therapy. These systems offer the potential for improved patient outcomes by enhancing drug targeting and minimizing adverse effects. Further research is needed to optimize nanogel design, evaluate their safety and efficacy in clinical trials, and explore their potential for personalized medicine.

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Section: Controlled Release Of Nanogelsmentioning

confidence: 99%

Smart nanogels for cancer treatment from the perspective of functional groups

Yu,

Liu,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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“…Polymer-based nanocomposites with pH-responsive structures could be promising nanodrug systems for future cancer treatment. 122 , 123 However, changing pH in the human body is a long time process with incapability to be adjusted externally. This issue can be tackled via using polymers as solid supports or coating agents for MNPs as fillers to fabricate multifunctional polymer-based magnetic nanocarriers as remotely controlled drug delivery systems.…”

Section: Application Of Polymer In Stabilizing Magnetic Nanocompositesmentioning

confidence: 99%

How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature

Yusefi¹,

Shameli²,

Jahangirian³

et al. 2023

IJN

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Chemotherapy is the most prominent route in cancer therapy for prolonging the lifespan of cancer patients. However, its non-target specificity and the resulting off-target cytotoxicities have been reported. Recent in vitro and in vivo studies using magnetic nanocomposites (MNCs) for magnetothermal chemotherapy may potentially improve the therapeutic outcome by increasing the target selectivity. In this review, magnetic hyperthermia therapy and magnetic targeting using drug-loaded MNCs are revisited, focusing on magnetism, the fabrication and structures of magnetic nanoparticles, surface modifications, biocompatible coating, shape, size, and other important physicochemical properties of MNCs, along with the parameters of the hyperthermia therapy and external magnetic field. Due to the limited drug-loading capacity and low biocompatibility, the use of magnetic nanoparticles (MNPs) as drug delivery system has lost traction. In contrast, MNCs show higher biocompatibility, multifunctional physicochemical properties, high drug encapsulation, and multi-stages of controlled release for localized synergistic chemo-thermotherapy. Further, combining various forms of magnetic cores and pH-sensitive coating agents can generate a more robust pH, magneto, and thermo-responsive drug delivery system. Thus, MNCs are ideal candidate as smart and remotely guided drug delivery system due to a) their magneto effects and guideability by the external magnetic fields, b) on-demand drug release performance, and c) thermo-chemosensitization under an applied alternating magnetic field where the tumor is selectively incinerated without harming surrounding non-tumor tissues. Given the important effects of synthesis methods, surface modifications, and coating of MNCs on their anticancer properties, we reviewed the most recent studies on magnetic hyperthermia, targeted drug delivery systems in cancer therapy, and magnetothermal chemotherapy to provide insights on the current development of MNC-based anticancer nanocarrier.

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